The glomerular filtration rate estimated by new and old equations as a predictor of important outcomes in elderly patients

BMC Medicine

Jean Marie Degryse²  Pierre Wallemacq¹  Delphine Legrand²  Cathy Matheï²  Wim Adriaensen²  Bert Vaes²  Gijs Van Pottelbergh² 

[1] Laboratory of Analytical Biochemistry, Cliniques Universitaires St Luc, Université Catholique de Louvain, Brussels, Belgium;Institute of Health and Society, Université Catholique de Louvain, Brussels, Belgium

关键词: Renal function;    Mortality;    Hospitalizations;    eGFR;    Cardiovascular events;   

Others  :  854983
DOI  :  10.1186/1741-7015-12-27

 received in 2013-10-17, accepted in 2014-01-10,  发布年份 2014

【 摘 要 】

Background

The prevalence of chronic kidney disease (CKD) increases with age, and new glomerular filtration rate-estimating equations have recently been validated. The epidemiology of CKD in older individuals and the relationship between a low estimated glomerular filtration rate as calculated by these equations and adverse outcomes remains unknown.

Methods

Data from the BELFRAIL study, a prospective, population-based cohort study of 539 individuals aged 80 years and older, were used. For every participant, five equations were used to calculate estimated glomerular filtration rate based on serum creatinine and/or cystatin C values: MDRD, CKD-EPIcreat, CKD-EPIcyst, CKD-EPIcreatcyst, and BIS equations. The outcomes analyzed included mortality combined with the necessity of new renal replacement therapy, severe cardiovascular events, and hospitalization.

Results

During the follow-up period, which was an average of 2.9 years, 124 participants died, 7 required renal replacement therapy, 271 were hospitalized, and 73 had a severe cardiovascular event. The prevalence of estimated glomerular filtration rate values <60 mL/min/1.73 m² differed depending on the equation used as follows: 44% (MDRD), 45% (CKD-EPIcreat), 75% (CKD-EPIcyst), 65% (CKD-EPIcreatcyst), and 80% (BIS). All of the glomerular filtration rate-estimating equations revealed that higher cardiovascular mortality was associated with lower estimated glomerular filtration rates and that higher probabilities of hospitalization were associated with estimated glomerular filtration rates <30 mL/min/1.73 m². A lower estimated glomerular filtration rate did not predict a higher probability of severe cardiovascular events, except when using the CKD-EPIcyst equation. By calculating the net reclassification improvement, CKD-EPIcyst and CKD-EPIcreatcyst were shown to predict mortality (+25% and +18%) and severe cardiovascular events (+7% and +9%) with the highest accuracy. The BIS equation was less accurate in predicting mortality (-12%).

Conclusion

Higher prevalence of CKD were found using the CKD-EPIcyst, CKD-EPIcreatcyst, and BIS equations compared with the MDRD and CKD-EPIcreat equations. The new CKD-EPIcreatcyst and CKD-EPIcyst equations appear to be better predictors of mortality and severe cardiovascular events.

【 授权许可】

   
2014 Van Pottelbergh et al.; licensee BioMed Central Ltd.

【 图 表 】

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