The gut microbiota of Colombians differs from that of Americans, Europeans and Asians

BMC Microbiology

Gloria M Agudelo²  Beatriz E Valdes³  Bernadette Klotz¹  Juan S Escobar⁴ 

[1] Current address: Instituto Alpina de Investigación, Alpina S.A., Km. 3 vía Briceño-Sopó, Sopó, Colombia;Current address: Nutrition and Dietetic School, University of Antioquia, Calle 67 #53-108, Medellín, Colombia;Current address: Faculty of Health, Institución Universitaria Colegio Mayor de Antioquia, Carrera 78 #65-46, Medellín, Colombia;Vidarium Nutrition, Health and Wellness Research Center, Grupo Nutresa, Calle 8 sur #50-67, Medellín, Colombia

关键词: Colombia;    Latin America;    Pyrosequencing;    Obesity;    Bacteroidetes;    Firmicutes;    Geography;    Microbiome;    Bacterial diversity;   

Others  :  1090720
DOI  :  10.1186/s12866-014-0311-6

 received in 2014-03-04, accepted in 2014-11-25,  发布年份 2014

【 摘 要 】

Background

The composition of the gut microbiota has recently been associated with health and disease, particularly with obesity. Some studies suggested a higher proportion of Firmicutes and a lower proportion of Bacteroidetes in obese compared to lean people; others found discordant patterns. Most studies, however, focused on Americans or Europeans, giving a limited picture of the gut microbiome. To determine the generality of previous observations and expand our knowledge of the human gut microbiota, it is important to replicate studies in overlooked populations. Thus, we describe here, for the first time, the gut microbiota of Colombian adults via the pyrosequencing of the 16S ribosomal DNA (rDNA), comparing it with results obtained in Americans, Europeans, Japanese and South Koreans, and testing the generality of previous observations concerning changes in Firmicutes and Bacteroidetes with increasing body mass index (BMI).

Results

We found that the composition of the gut microbiota of Colombians was significantly different from that of Americans, Europeans and Asians. The geographic origin of the population explained more variance in the composition of this bacterial community than BMI or gender. Concerning changes in Firmicutes and Bacteroidetes with obesity, in Colombians we found a tendency in Firmicutes to diminish with increasing BMI, whereas no change was observed in Bacteroidetes. A similar result was found in Americans. A more detailed inspection of the Colombian dataset revealed that five fiber-degrading bacteria, including Akkermansia, Dialister, Oscillospira, Ruminococcaceae and Clostridiales, became less abundant in obese subjects.

Conclusion

We contributed data from unstudied Colombians that showed that the geographic origin of the studied population had a greater impact on the composition of the gut microbiota than BMI or gender. Any strategy aiming to modulate or control obesity via manipulation of this bacterial community should consider this effect.

【 授权许可】

   
2014 Escobar et al.; licensee BioMed Central.

【 图 表 】

Figure 1.

Figure 2.

Figure 3.

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