BMC Public Health | |
Epidemiology and awareness of hypertension in a rural Ugandan community: a cross-sectional study | |
Diane V Havlir4  Edwin D Charlebois3  Moses R Kamya5  Harsha Thirumurthy2  Maya L Petersen1  Gabriel Chamie4  Vivek Jain4  Elvin H Geng4  Jane Kabami4  Tamara D Clark4  Dalsone Kwarisiima6  Prashant Kotwani4  | |
[1] School of Public Health, University of California, Berkeley, California, USA;Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA;Center for AIDS Prevention Studies, Department of Medicine, University of California San Francisco, San Francisco, California, USA;Makerere University-University of California San Francisco (MU-UCSF) Research Collaboration, Mbarara, Uganda;Department of Medicine, School of Medicine, Makerere University College of Health Sciences, Kampala, Uganda;Mulago Joint AIDS Program, Kampala and Mbarara, Mbarara, Uganda | |
关键词: Rural; Uganda; Sub-Saharan Africa; Public health; Health campaign; Community health; Non-communicable disease; Blood pressure; Epidemiology; Hypertension; | |
Others : 1161474 DOI : 10.1186/1471-2458-13-1151 |
|
received in 2013-07-01, accepted in 2013-12-05, 发布年份 2013 | |
【 摘 要 】
Background
Hypertension is one of the largest causes of preventable morbidity and mortality worldwide. There are few population-based studies on hypertension epidemiology to guide public health strategies in sub-Saharan Africa. Using a community-based strategy that integrated screening for HIV and non-communicable diseases, we determined the prevalence, awareness, treatment rates, and sociodemographic factors associated with hypertension in rural Uganda.
Methods
A household census was performed to enumerate the population in Kakyerere parish in Mbarara district, Uganda. A multi-disease community-based screening campaign for hypertension, diabetes, and HIV was then conducted. During the campaign, all adults received a blood pressure (BP) measurement and completed a survey examining sociodemographic factors. Hypertension was defined as elevated BP (≥140/≥90 mmHg) on the lowest of three BP measurements or current use of antihypertensives. Prevalence was calculated and standardized to age distribution. Sociodemographic factors associated with hypertension were evaluated using a log-link Poisson regression model with robust standard errors.
Results
Community participation in the screening campaign was 65%, including 1245 women and 1007 men. The prevalence of hypertension was 14.6%; awareness of diagnosis (38.1%) and current receipt of treatment (20.6%) were both low. Age-standardized to the WHO world standard population, hypertension prevalence was 19.8%, which is comparable to 21.6% in the US and 18.4% in the UK. Sociodemographic factors associated with hypertension included increasing age, male gender, overweight, obesity, diabetes, alcohol consumption, and family history. Prevalence of modifiable factors was high: 28.3% women were overweight/obese and 24.1% men consumed ≥10 alcoholic drinks per month.
Conclusions
We found a substantial burden of hypertension in rural Uganda. Awareness and treatment of hypertension is low in this region. Enhanced community-based education and prevention efforts tailored to addressing modifiable factors are needed.
【 授权许可】
2013 Kotwani et al.; licensee BioMed Central Ltd.
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
20150413030546417.pdf | 204KB | download |
【 参考文献 】
- [1]Leon DA: Cities, urbanization and health. Int J Epidemiol 2008, 37:4-8.
- [2]Popkin BM: Global nutrition dynamics: the world is shifting rapidly toward a diet linked with noncommunicable diseases. Am J Clin Nutr 2006, 84:289-298.
- [3]Lawes CM, Vander Hoorn S, Rodgers A: Global burden of blood-pressure-related disease, 2001. Lancet 2008, 371:1513-1518.
- [4]Yach D, Hawkes C, Gould CL, Hofman KJ: The global burden of chronic diseases: overcoming impediments to prevention and control. Jama 2004, 291:2616-2622.
- [5]Lim SS, Vos T, Flaxman AD, Danaei G, Shibuya K, Adair-Rohani H, Amann M, Anderson HR, Andrews KG, Aryee M, et al.: A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 2012, 380:2224-2260.
- [6]Kearney PM, Whelton M, Reynolds K, Muntner P, Whelton PK, He J: Global burden of hypertension: analysis of worldwide data. Lancet 2005, 365:217-223.
- [7]Twagirumukiza M, De Bacquer D, Kips JG, de Backer G, Stichele RV, Van Bortel LM: Current and projected prevalence of arterial hypertension in sub-Saharan Africa by sex, age and habitat: an estimate from population studies. J Hypertens 2011, 29:1243-1252.
- [8]Mensah GA: Epidemiology of stroke and high blood pressure in Africa. Heart 2008, 94:697-705.
- [9]Opie LH, Seedat YK: Hypertension in sub-Saharan African populations. Circulation 2005, 112:3562-3568.
- [10]Smart T: HIV and non-communicable diseases (NCDs). In Book HIV and Non-communicable Diseases (NCDs). City: NAM; 2011.
- [11]Addo J, Smeeth L, Leon DA: Hypertension in sub-saharan Africa: a systematic review. Hypertension 2007, 50:1012-1018.
- [12]Maher D, Waswa L, Baisley K, Karabarinde A, Unwin N: Epidemiology of hypertension in low-income countries: a cross-sectional population-based survey in rural Uganda. J Hypertens 2011, 29:1061-1068.
- [13]Bloom DE, Cafiero ET, Jané-Llopis E, Abrahams-Gessel S, Bloom LR, Fathima S, Feigl AB, Gaziano T, Mowafi M, Pandya A, Prettner K, Rosenberg L, Seligman B, Stein AZ, Weinstein C: The global economic burden of noncommunicable diseases. In Book The Global Economic Burden of Noncommunicable Diseases (Editor ed.^eds.). City: World Economic Forum; 2011.
- [14]Dalal S, Beunza JJ, Volmink J, Adebamowo C, Bajunirwe F, Njelekela M, Mozaffarian D, Fawzi W, Willett W, Adami HO, Holmes MD: Non-communicable diseases in sub-Saharan Africa: what we know now. Int J Epidemiol 2011, 40:885-901.
- [15]de Ramirez SS, Enquobahrie DA, Nyadzi G, Mjungu D, Magombo F, Ramirez M, Sachs SE, Willett W: Prevalence and correlates of hypertension: a cross-sectional study among rural populations in sub-Saharan Africa. J Hum Hypertens 2010, 24:786-795.
- [16]Hendriks ME, Wit FW, Roos MT, Brewster LM, Akande TM, de Beer IH, Mfinanga SG, Kahwa AM, Gatongi P, Van Rooy G, et al.: Hypertension in sub-Saharan Africa: cross-sectional surveys in four rural and urban communities. PLoS One 2012, 7:e32638.
- [17]Tumwesigye E, Wana G, Kasasa S, Muganzi E, Nuwaha F: High uptake of home-based, district-wide, HIV counseling and testing in Uganda. AIDS Patient Care STDS 2010, 24:735-741.
- [18]Lugada E, Millar D, Haskew J, Grabowsky M, Garg N, Vestergaard M, Kahn JG, Muraguri N, Mermin J: Rapid implementation of an integrated large-scale HIV counseling and testing, malaria, and diarrhea prevention campaign in rural Kenya. PloS one 2010, 5:e12435.
- [19]Rabkin M, El-Sadr WM: Why reinvent the wheel? Leveraging the lessons of HIV scale-up to confront non-communicable diseases. Glob Public Health 2011, 6:247-256.
- [20]Beaglehole R, Epping-Jordan J, Patel V, Chopra M, Ebrahim S, Kidd M, Haines A: Improving the prevention and management of chronic disease in low-income and middle-income countries: a priority for primary health care. Lancet 2008, 372:940-949.
- [21]Tollman SM, Kahn K, Sartorius B, Collinson MA, Clark SJ, Garenne ML: Implications of mortality transition for primary health care in rural South Africa: a population-based surveillance study. Lancet 2008, 372:893-901.
- [22]Rabkin M, Nishtar S: Scaling up chronic care systems: leveraging HIV programs to support noncommunicable disease services. J Acquir Immune Defic Syndr 2011, 57(Suppl 2):S87-S90.
- [23]Chamie G, Kwarisiima D, Clark TD, Kabami J, Jain V, Geng E, Petersen ML, Thirumurthy H, Kamya MR, Havlir DV, Charlebois ED: Leveraging rapid community-based HIV testing campaigns for non-communicable diseases in rural Uganda. PloS one 2012, 7:e43400.
- [24]Whitworth JA: 2003 World Health Organization (WHO)/International Society of Hypertension (ISH) statement on management of hypertension. J Hypertens 2003, 21:1983-1992.
- [25]Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL Jr, Jones DW, Materson BJ, Oparil S, Wright JT Jr, Roccella EJ: Seventh report of the joint national committee on prevention, detection, evaluation, and treatment of high blood pressure. Hypertension 2003, 42:1206-1252.
- [26]Uganda Clinical Guidelines. http://www.health.go.ug/docs/ucg_2010.pdf webcite
- [27]Labhardt ND, Balo JR, Ndam M, Manga E, Stoll B: Improved retention rates with low-cost interventions in hypertension and diabetes management in a rural African environment of nurse-led care: a cluster-randomised trial. Trop Med Int Health 2011, 16:1276-1284.
- [28]Klein RJ, Schoenborn CA: Age adjustment using the, projected U.S. population. Healthy People 2010 Stat Notes 2000, 2001:1-10.
- [29]Ahmad OB, Boschi-Pinto C, Lopez AD, Murray CJL, Lozano R, Inoue M: Age standardization of rates: a new WHO standard. In Book Age Standardization of Rates: A New WHO standard (Editor ed.^eds.). Geneva: World Health Organization; 2001.
- [30]Syed FF, Sani MU: Recent advances in HIV-associated cardiovascular diseases in Africa. Heart 2013, 99:1146-1153.
- [31]Musinguzi G, Nuwaha F: Prevalence, awareness and control of hypertension in Uganda. PloS one 2013, 8:e62236.
- [32]Twagirumukiza M, Van Bortel LM: Management of hypertension at the community level in sub-Saharan Africa (SSA): towards a rational use of available resources. J Hum Hypertens 2011, 25:47-56.
- [33]Unwin N, Setel P, Rashid S, Mugusi F, Mbanya JC, Kitange H, Hayes L, Edwards R, Aspray T, Alberti KG: Noncommunicable diseases in sub-Saharan Africa: where do they feature in the health research agenda? Bull World Health Organ 2001, 79:947-953.
- [34]Ezzati M, Lopez AD, Rodgers A, Vander Hoorn S, Murray CJ: Selected major risk factors and global and regional burden of disease. Lancet 2002, 360:1347-1360.
- [35]Murray CJ, Lopez AD: Global mortality, disability, and the contribution of risk factors: Global Burden of Disease Study. Lancet 1997, 349:1436-1442.
- [36]Fezeu L, Kengne AP, Balkau B, Awah PK, Mbanya JC: Ten-year change in blood pressure levels and prevalence of hypertension in urban and rural Cameroon. J Epidemiol Community Health 2010, 64:360-365.
- [37]Cappuccio FP, Micah FB, Emmett L, Kerry SM, Antwi S, Martin-Peprah R, Phillips RO, Plange-Rhule J, Eastwood JB: Prevalence, detection, management, and control of hypertension in Ashanti, West Africa. Hypertension 2004, 43:1017-1022.
- [38]van der Sande MA, Milligan PJ, Nyan OA, Rowley JT, Banya WA, Ceesay SM, Dolmans WM, Thien T, McAdam KP, Walraven GE: Blood pressure patterns and cardiovascular risk factors in rural and urban gambian communities. J Hum Hypertens 2000, 14:489-496.
- [39]Edwards R, Unwin N, Mugusi F, Whiting D, Rashid S, Kissima J, Aspray TJ, Alberti KG: Hypertension prevalence and care in an urban and rural area of Tanzania. J Hypertens 2000, 18:145-152.
- [40]Wamala JF, Karyabakabo Z, Ndungutse D, Guwatudde D: Prevalence factors associated with hypertension in Rukungiri district, Uganda–a community-based study. Afr Health Sci 2009, 9:153-160.
- [41]Barnighausen T, Welz T, Hosegood V, Batzing-Feigenbaum J, Tanser F, Herbst K, Hill C, Newell ML: Hiding in the shadows of the HIV epidemic: obesity and hypertension in a rural population with very high HIV prevalence in South Africa. J Hum Hypertens 2008, 22:236-239.
- [42]Malaza A, Mossong J, Barnighausen T, Newell ML: Hypertension and obesity in adults living in a high HIV prevalence rural area in South Africa. PloS one 2012, 7:e47761.
- [43]Schutte AE, Schutte R, Huisman HW, van Rooyen JM, Fourie CM, Malan NT, Malan L, Mels CM, Smith W, Moss SJ, et al.: Are behavioural risk factors to be blamed for the conversion from optimal blood pressure to hypertensive status in Black South Africans? A 5-year prospective study. Int J Epidemiol 2012, 41:1114-1123.
- [44]Grinspoon SK: Metabolic syndrome and cardiovascular disease in patients with human immunodeficiency virus. Am J Med 2005, 118(Suppl 2):23S-28S.
- [45]Political Declaration of the High-level Meeting of the General Assembly on the Prevention and Control of Non-communicable Diseases. http://www.who.int/nmh/events/un_ncd_summit2011/political_declaration_en.pdf webcite