CDKN2A-rs10811661 polymorphism, waist-hip ratio, systolic blood pressure, and dyslipidemia are the independent risk factors for prediabetes in a Vietnamese population

BMC Genetics

Trinh Thi Hong Nhung³  Bui Thi Nhung²  Pham Tran Phuong³  Nguyen Thi Trung Thu¹  Tran Quang Binh³ 

[1]Hanoi National University of Education, 136 Xuan Thuy Street, Hanoi, Vietnam

[2]National Institute of Nutrition, 48B Tang Bat Ho Street, Hanoi 112807, Vietnam

[3]National Institute of Hygiene and Epidemiology, 1 Yersin, Hanoi 112800, Vietnam

关键词: Vietnamese population;    Single nucleotide polymorphism;    Prediabetes;    CDKN2A gene;    Association study;   

Others  :  1224623
DOI  :  10.1186/s12863-015-0266-0

 received in 2015-04-16, accepted in 2015-08-21,  发布年份 2015

【 摘 要 】

Background

People with prediabetes are at greater risk for heart attack, stroke, kidney disease, vision problems, nerve damage and high blood pressure, compared to those without the disease. Prediabetes is a complex disorder involving both genetic and environmental factors in its pathogenesis. This cross-sectional study aimed to investigate the independent risk factors for prediabetes, considering the contribution of genetic factors (TCF7L2-rs7903146, IRS1-rs1801278, INSR-rs3745551, CDKN2A-rs10811661, and FTO-rs9939609), socio-economic status, and lifestyle factors.

Results

Among the candidate genes studied, the CDKN2A-rs10811661 polymorphism was found to be the most significant factor associated with prediabetes in the model unadjusted and adjusted for age, sex, obesity-related traits, systolic blood pressure, dyslipidemia, socio-economic status, and lifestyle factors. In the final model, the CDKN2A-rs10811661 polymorphism (OR per T allele = 1.22, 95 % CI = 1.04–1.44, P = 0.017), systolic blood pressure (OR per 10 mmHg = 1.14, 95 % CI = 1.08–1.20, P < 0.0001), waist-hip ratio (OR = 1.25, 95 % CI = 1.10–1.42, P < 0.0001), dyslipidemia (OR = 1.57, 95 % CI = 1.15–2.14, P = 0.004), and residence (OR = 1.93, 95 % CI = 2.82–4.14, P < 0.0001) were the most significant independent predictors of prediabetes, in which the power of the adjusted prediction model was 0.646.

Conclusions

The study suggested that the CDKN2A-rs10811661 polymorphism, waist-hip ratio, systolic blood pressure, and dyslipidemia were significantly associated with the increased risk of prediabetes in a Vietnamese population. The studied genetic variant had a small effect on prediabetes.

【 授权许可】

   
2015 Binh et al.

【 图 表 】

Fig. 1.

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