Comparison of placental growth factor and fetal flow Doppler ultrasonography to identify fetal adverse outcomes in women with hypertensive disorders of pregnancy: an observational study

BMC Pregnancy and Childbirth

János Rigó Jr¹  Bálint Nagy¹  Gergely Fügedi¹  Balázs Stenczer¹  Nóra Gullai¹  Attila Molvarec¹ 

[1] First Department of Obstetrics and Gynecology, Semmelweis University, Baross utca 27, Budapest H-1088, Hungary

关键词: Growth restriction;    Doppler;    IUGR;    Preeclampsia;    PlGF;    Placental growth factor;    Hypertension;   

Others  :  1137919
DOI  :  10.1186/1471-2393-13-161

 received in 2013-04-25, accepted in 2013-08-10,  发布年份 2013

【 摘 要 】

Background

Hypertensive disorders of pregnancy and intrauterine growth restriction (IUGR) are leading causes of maternal and perinatal morbidity and mortality. Failure to detect intrauterine growth restriction in women at high risk has been highlighted as a significant avoidable cause of serious fetal outcome. In this observational study we compare fetal flow using Doppler ultrasonography with a new test for placental growth factor (PlGF) to predict fetal adverse events.

Methods

Eighty-nine women with hypertensive disorders of pregnancy (24 with chronic hypertension, 17 with gestational hypertension, 12 with HELLP syndrome, 19 with preeclampsia and 17 with superimposed preeclampsia) were enrolled. A single maternal blood sample to measure free PlGF (Alere Triage) taken before 35 weeks of pregnancy was compared to the last Doppler ultrasound measurement of fetal flow before delivery. PlGF was classified as normal (PlGF≥100 pg/ml), low (12

Results

In total 61/89 women had a preterm birth and 22 infants had IUGR. Of those who delivered preterm, 20/20 women with abnormal fetal flow and 36/41 (87.8%) women with normal fetal flow had low or very low PlGF. Of those infants with IUGR, 22/22 had low or very low maternal PlGF and 10/22 had abnormal fetal flow.

Conclusions

PlGF may provide useful information before 35^th gestational week to identify fetuses requiring urgent delivery, and those at risk of later adverse outcomes not identified by fetal flow Doppler ultrasonography.

【 授权许可】

   
2013 Molvarec et al.; licensee BioMed Central Ltd.

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