Feasibility of intensity-modulated and image-guided radiotherapy for locally advanced esophageal cancer

BMC Cancer

Nam P Nguyen²  Siyoung Jang⁴  Jacqueline Vock⁸  Vincent Vinh-Hung⁹  Alexander Chi⁷  Paul Vos³  Judith Pugh¹  Richard A Vo⁵  Misty Ceizyk⁴  Anand Desai⁶  Lexie Smith-Raymond⁴ 

[1] Department of Pathology, University of Arizona, Tucson, AZ, USA

[2] Department of Radiation Oncology, Howard University Hospital, 2401 Georgia Avenue, N.W., Room 2055, Washington, DC 20060, USA

[3] Department of Biostatistics, East Carolina University, Greenville, NC, USA

[4] Department of Radiation Oncology, University of Arizona, Tucson, AZ, USA

[5] Department of Pediatry, University of Virginia, Charlottesville, VA, USA

[6] Department of Radiation Oncology, Akron City Hospital, Akron, OH, USA

[7] Department of Radiation Oncology, University of West Virginia, Morgantown, WV, USA

[8] Department of Radiation Oncology, Lindenhofspital, Bern, Switzerland

[9] Department of Radiation Oncology, University Hospitals of Geneva, Geneva, Switzerland

关键词: Normal tissue sparing;    Tomotherapy;    Esophageal cancer;   

Others  :  858892
DOI  :  10.1186/1471-2407-14-265

 received in 2013-01-31, accepted in 2014-04-14,  发布年份 2014

【 摘 要 】

Background

In this study the feasibility of intensity-modulated radiotherapy (IMRT) and tomotherapy-based image-guided radiotherapy (IGRT) for locally advanced esophageal cancer was assessed.

Methods

A retrospective study of ten patients with locally advanced esophageal cancer who underwent concurrent chemotherapy with IMRT (1) and IGRT (9) was conducted. The gross tumor volume was treated to a median dose of 70 Gy (62.4-75 Gy).

Results

At a median follow-up of 14 months (1-39 months), three patients developed local failures, six patients developed distant metastases, and complications occurred in two patients (1 tracheoesophageal fistula, 1 esophageal stricture requiring repeated dilatations). No patients developed grade 3-4 pneumonitis or cardiac complications.

Conclusions

IMRT and IGRT may be effective for the treatment of locally advanced esophageal cancer with acceptable complications.

【 授权许可】

   
2014 Nguyen et al.; licensee BioMed Central Ltd.

【 图 表 】

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