Organ doses from hepatic radioembolization with 90Y, 153Sm, 166Ho and 177Lu: A Monte Carlo simulation study using Geant4

13th South-East Asian Congress of Medical Physics 2015

物理学;医药卫生

Hashikin, N.A.A.^1 ; Yeong, C.H.^1 ; Guatelli, S.^2 ; Abdullah, B.J.J.^1 ; Ng, K.H.^1 ; Malaroda, A.^2 ; Rosenfeld, A.B.^2 ; Perkins, A.C.^3

Department of Biomedical Imaging, University of Malaya Research Imaging Centre, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia^1

Centre for Medical Radiation Physics, Faculty of Engineering and Information Sciences, University of Wollongong, Wollongong

NSW, Australia^2

Radiological and Imaging Sciences, Medical Physics and Clinical Engineering, Medical School, University of Nottingham, Nottingham, United Kingdom^3

关键词: Beta emissions;    Dose equivalent;    Gamma emission;    Gamma energy;    Liver cancers;    Normal tissue sparing;    Radioembolization;    Tolerance limits;   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/694/1/012059/pdf
DOI  :  10.1088/1742-6596/694/1/012059

学科分类：卫生学

来源: IOP

【 摘 要 】

90Y-radioembolization is a palliative treatment for liver cancer.90Y decays via beta emission, making imaging difficult due to absence of gamma radiation. Since post-procedure imaging is crucial, several theranostic radionuclides have been explored as alternatives. However, exposures to gamma radiation throughout the treatment caused concern for the organs near the liver. Geant4 Monte Carlo simulation using MIRD Pamphlet 5 reference phantom was carried out. A spherical tumour with 4.3cm radius was modelled within the liver. 1.82GBq of90Y sources were isotropically distributed within the tumour, with no extrahepatic shunting. The simulation was repeated with153Sm,166Ho and177Lu. The estimated tumour doses for all radionuclides were 262.9Gy. Tumour dose equivalent to 1.82GBq90Y can be achieved with 8.32, 5.83, and 4.44GBq for153Sm,166Ho and177Lu, respectively. Normal liver doses by the other radionuclides were lower than90Y, hence beneficial for normal tissue sparing. The organ doses from153Sm and177Lu were relatively higher due to higher gamma energy, but were still well below 1Gy.166Ho,177Lu and153Sm offer useful gamma emission for post-procedure imaging. They show potential as90Y substitutes, delivering comparable tumour doses, lower normal liver doses and other organs doses far below the tolerance limit.