Toxoplasma gondii exposure in patients suffering from mental and behavioral disorders due to psychoactive substance use

BMC Infectious Diseases

Isabel Beristain-García¹  Oliver Liesenfeld⁵  Yesenia Alarcón-Alvarado¹  María Nalleli Ortiz-Jurado⁴  Luis Francisco Sánchez-Anguiano³  Misael Salcedo-Jaquez²  Jesús Hernández-Tinoco³  Sandy Janet Pacheco-Vega²  David Carrillo-Oropeza⁴  Cosme Alvarado-Esquivel² 

[1] Faculty of Nursing and Obstetrics, Juárez University of Durango State, Avenida Cuauhtémoc 223, Durango, 34000, Mexico;Biomedical Research Laboratory, Faculty of Medicine and Nutrition, Juárez University of Durango State, Avenida Universidad S/N, Durango, 34000, Mexico;Institute for Scientific Research “Dr. Roberto Rivera-Damm”, Juárez University of Durango State, Avenida Universidad S/N, Durango, 34000, Mexico;Hospital of Mental Health “Dr. Miguel Vallebueno”, Secretary of Health, Avenida Fidel Velázquez S/N, Durango, 34234, Mexico;Current address: Chief Medical Officer, Medical and Scientific Affairs, Roche Molecular Systems, Pleasanton 94588, CA, USA

关键词: Mexico;    Epidemiology;    Psychoactive drug Abuse;    Psychiatric patients;    Seroprevalence;    Infection;    Toxoplasma gondii;   

Others  :  1172086
DOI  :  10.1186/s12879-015-0912-1

 received in 2014-10-09, accepted in 2015-03-24,  发布年份 2015

【 摘 要 】

Background

Toxoplasma gondii infection has been associated with psychiatric diseases. However, there is no information about the link between this infection and patients with mental and behavioral disorders due to psychoactive substance use.

Methods

We performed a case-control study with 149 psychiatric patients suffering from mental and behavioral disorders due to psychoactive substance use and 149 age- and gender-matched control subjects of the general population. We searched for anti-T. gondii IgG and IgM antibodies in the sera of participants by means of commercially available enzyme-linked immunoassays. Seroprevalence association with socio-demographic, clinical and behavioral characteristics in psychiatric patients was also investigated.

Results

Anti-T. gondii IgG antibodies were present in 15 (10.1%) of 149 cases and in 14 (9.4%) of 149 controls (P = 1.0). Anti-T. gondii IgM antibodies were found in 11 (7.4%) of the 149 cases and in 16 (10.7%) of the 149 controls (P = 0.31). No association of T. gondii exposure with socio-demographic characteristics of patients was found. Multivariate analysis of clinical and behavioral characteristics of cases showed that T. gondii seropositivity was positively associated with consumption of opossum meat (OR = 10.78; 95% CI: 2.16-53.81; P = 0.003) and soil flooring at home (OR = 11.15; 95% CI: 1.58-78.92; P = 0.01), and negatively associated with suicidal ideation (OR = 0.17; 95% CI: 0.05-0.64; P = 0.008).

Conclusions

Mental and behavioral disorders due to psychoactive substance use do not appear to represent an increased risk for T. gondii exposure. This is the first report of a positive association of T. gondii exposure with consumption of opossum meat. Further studies to elucidate the role of T. gondii infection in suicidal ideation and behavior are needed to develop optimal strategies for the prevention of infection with T. gondii.

【 授权许可】

   
2015 Alvarado-Esquivel et al.; licensee BioMed Central.

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