期刊论文详细信息
BMC Infectious Diseases
Toxoplasma gondii exposure in patients suffering from mental and behavioral disorders due to psychoactive substance use
Isabel Beristain-García1  Oliver Liesenfeld5  Yesenia Alarcón-Alvarado1  María Nalleli Ortiz-Jurado4  Luis Francisco Sánchez-Anguiano3  Misael Salcedo-Jaquez2  Jesús Hernández-Tinoco3  Sandy Janet Pacheco-Vega2  David Carrillo-Oropeza4  Cosme Alvarado-Esquivel2 
[1] Faculty of Nursing and Obstetrics, Juárez University of Durango State, Avenida Cuauhtémoc 223, Durango, 34000, Mexico;Biomedical Research Laboratory, Faculty of Medicine and Nutrition, Juárez University of Durango State, Avenida Universidad S/N, Durango, 34000, Mexico;Institute for Scientific Research “Dr. Roberto Rivera-Damm”, Juárez University of Durango State, Avenida Universidad S/N, Durango, 34000, Mexico;Hospital of Mental Health “Dr. Miguel Vallebueno”, Secretary of Health, Avenida Fidel Velázquez S/N, Durango, 34234, Mexico;Current address: Chief Medical Officer, Medical and Scientific Affairs, Roche Molecular Systems, Pleasanton 94588, CA, USA
关键词: Mexico;    Epidemiology;    Psychoactive drug Abuse;    Psychiatric patients;    Seroprevalence;    Infection;    Toxoplasma gondii;   
Others  :  1172086
DOI  :  10.1186/s12879-015-0912-1
 received in 2014-10-09, accepted in 2015-03-24,  发布年份 2015
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【 摘 要 】

Background

Toxoplasma gondii infection has been associated with psychiatric diseases. However, there is no information about the link between this infection and patients with mental and behavioral disorders due to psychoactive substance use.

Methods

We performed a case-control study with 149 psychiatric patients suffering from mental and behavioral disorders due to psychoactive substance use and 149 age- and gender-matched control subjects of the general population. We searched for anti-T. gondii IgG and IgM antibodies in the sera of participants by means of commercially available enzyme-linked immunoassays. Seroprevalence association with socio-demographic, clinical and behavioral characteristics in psychiatric patients was also investigated.

Results

Anti-T. gondii IgG antibodies were present in 15 (10.1%) of 149 cases and in 14 (9.4%) of 149 controls (P = 1.0). Anti-T. gondii IgM antibodies were found in 11 (7.4%) of the 149 cases and in 16 (10.7%) of the 149 controls (P = 0.31). No association of T. gondii exposure with socio-demographic characteristics of patients was found. Multivariate analysis of clinical and behavioral characteristics of cases showed that T. gondii seropositivity was positively associated with consumption of opossum meat (OR = 10.78; 95% CI: 2.16-53.81; P = 0.003) and soil flooring at home (OR = 11.15; 95% CI: 1.58-78.92; P = 0.01), and negatively associated with suicidal ideation (OR = 0.17; 95% CI: 0.05-0.64; P = 0.008).

Conclusions

Mental and behavioral disorders due to psychoactive substance use do not appear to represent an increased risk for T. gondii exposure. This is the first report of a positive association of T. gondii exposure with consumption of opossum meat. Further studies to elucidate the role of T. gondii infection in suicidal ideation and behavior are needed to develop optimal strategies for the prevention of infection with T. gondii.

【 授权许可】

   
2015 Alvarado-Esquivel et al.; licensee BioMed Central.

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【 参考文献 】
  • [1]Dubey JP: Toxoplasmosis of animals and humans. 2nd edition. CRC Press, Boca Raton, Florida; 2010.
  • [2]Montoya JG, Liesenfeld O: Toxoplasmosis. Lancet 2004, 363:1965-76.
  • [3]Alvarado-Esquivel C, Liesenfeld O, Márquez-Conde JA, Estrada-Martínez S, Dubey JP: Seroepidemiology of infection with Toxoplasma gondii in workers occupationally exposed to water, sewage, and soil in Durango, Mexico. J Parasitol 2010, 96:847-50.
  • [4]Strabelli TM, Siciliano RF, Vidal Campos S, Bianchi Castelli J, Bacal F, Bocchi EA, et al.: Toxoplasma gondii myocarditis after adult heart transplantation: successful prophylaxis with pyrimethamine. J Trop Med 2012, 2012:853562.
  • [5]Osthoff M, Chew E, Bajel A, Kelsey G, Panek-Hudson Y, Mason K, et al.: Disseminated toxoplasmosis after allogeneic stem cell transplantation in a seronegative recipient. Transpl Infect Dis 2013, 15:E14-9.
  • [6]Maenz M, Schlüter D, Liesenfeld O, Schares G, Gross U, Pleyer U: Ocular toxoplasmosis past, present and new aspects of an old disease. Prog Retin Eye Res 2014, 39:77-106.
  • [7]Munoz M, Liesenfeld O, Heimesaat MM: Immunology of Toxoplasma gondii. Immunol Rev 2011, 240:269-85.
  • [8]Torgerson PR, Mastroiacovo P: The global burden of congenital toxoplasmosis: a systematic review. Bull World Health Organ 2013, 91:501-8.
  • [9]Alvarado-Esquivel C, Pacheco-Vega SJ, Hernández-Tinoco J, Centeno-Tinoco MM, Beristain-García I, Sánchez-Anguiano LF, et al.: Miscarriage history and Toxoplasma gondii infection: a cross-sectional study in women in Durango City, Mexico. Eur J Microbiol Immunol (Bp) 2014, 4:117-22.
  • [10]Alvarado-Esquivel C, Alanis-Quiñones OP, Arreola-Valenzuela MA, Rodríguez-Briones A, Piedra-Nevarez LJ, Duran-Morales E, et al.: Seroepidemiology of Toxoplasma gondii infection in psychiatric inpatients in a northern Mexican city. BMC Infect Dis 2006, 6:178. BioMed Central Full Text
  • [11]Bachmann S, Schröder J, Bottmer C, Torrey EF, Yolken RH: Psychopathology in first-episode schizophrenia and antibodies to Toxoplasma gondii. Psychopathology 2005, 38:87-90.
  • [12]Alvarado-Esquivel C, Urbina-Álvarez JD, Estrada-Martínez S, Torres-Castorena A, Molotla-de-León G, Liesenfeld O, et al.: Toxoplasma gondii infection and schizophrenia: a case control study in a low Toxoplasma seroprevalence Mexican population. Parasitol Int 2011, 60:151-5.
  • [13]Hinze-Selch D, Däubener W, Erdag S, Wilms S: The diagnosis of a personality disorder increases the likelihood for seropositivity to Toxoplasma gondii in psychiatric patients. Folia Parasitol (Praha) 2010, 57:129-35.
  • [14]Miman O, Mutlu EA, Ozcan O, Atambay M, Karlidag R, Unal S: Is there any role of Toxoplasma gondii in the etiology of obsessive-compulsive disorder? Psychiatry Res 2010, 177:263-5.
  • [15]Alvarado-Esquivel C, Estrada-Martínez S, Pizarro-Villalobos H, Arce-Quiñones M, Liesenfeld O, Dubey JP: Seroepidemiology of Toxoplasma gondii infection in general population in a northern Mexican city. J Parasitol 2011, 97:40-3.
  • [16]Alvarado-Esquivel C, Pacheco-Vega SJ, Hernández-Tinoco J, Saldaña-Simental DE, Sánchez-Anguiano LF, Salcedo-Jáquez M, et al.: Lack of association between Toxoplasma gondii infection and occupational exposure to animals. Eur J Microbiol Immunol (Bp) 2014, 4:184-92.
  • [17]World Health Organization: The ICD-10 classification of mental and behavioural disorders: clinical descriptions and diagnostic guidelines. World Health Organization, Geneva; 1992.
  • [18]Alvarado-Esquivel C, Mercado-Suarez MF, Rodríguez-Briones A, Fallad-Torres L, Ayala-Ayala JO, Nevarez-Piedra LJ, et al.: Seroepidemiology of infection with Toxoplasma gondii in healthy blood donors of Durango. Mexico BMC Infect Dis 2007, 7:75. BioMed Central Full Text
  • [19]Alvarado-Esquivel C, Liesenfeld O, Márquez-Conde JA, Cisneros-Camacho A, Estrada-Martínez S, Martínez-García SA, et al.: Seroepidemiology of infection with Toxoplasma gondii in waste pickers and waste workers in Durango, Mexico. Zoonoses Public Health 2008, 55:306-12.
  • [20]Alvarado-Esquivel C, Hernández-Tinoco J, Sánchez-Anguiano LF, Ramos-Nevárez A, Cerrillo-Soto SM, Sáenz-Soto L, et al.: High seroprevalence of Toxoplasma gondii infection in inmates: a case control study in Durango City, Mexico. Eur J Microbiol Immunol (Bp) 2014, 4:76-82.
  • [21]Flegr J: Influence of latent Toxoplasma infection on human personality, physiology and morphology: pros and cons of the Toxoplasma-human model in studying the manipulation hypothesis. J Exp Biol 2013, 216:127-33.
  • [22]Webster JP, Kaushik M, Bristow GC, McConkey GA: Toxoplasma gondii infection, from predation to schizophrenia: can animal behaviour help us understand human behaviour? J Exp Biol 2013, 216:99-112.
  • [23]Buchy P, Follézou JY, Lien TX, An TT, Tram LT, Tri DV, et al.: Serological study of toxoplasmosis in Vietnam in a population of drug users (Ho Chi Minh City) and pregnant women (Nha Trang). Bull Soc Pathol Exot 2003, 96:46-7.
  • [24]Gutiérrez J, Roldán C, Maroto MC: Seroprevalence of human toxoplasmosis. Microbios 1996, 85:73-5.
  • [25]Dubey JP, Velmurugan GV, Alvarado-Esquivel C, Alvarado-Esquivel D, Rodríguez-Peña S, Martínez-García S, et al.: Isolation of Toxoplasma gondii from animals in Durango, Mexico. J Parasitol 2009, 95:319-22.
  • [26]Siqueira DB, Aléssio FM, Mauffrey JF, Marvulo MF, Ribeiro VO, Oliveira RL, et al.: Seroprevalence of Toxoplasma gondii in wild marsupials and rodents from the Atlantic forest of Pernambuco State, northeastern region, Brazil. J Parasitol 2013, 99:1140-3.
  • [27]Pena HF, Marvulo MF, Horta MC, Silva MA, Silva JC, Siqueira DB, et al.: Isolation and genetic characterisation of Toxoplasma gondii from a red-handed howler monkey (Alouatta belzebul), a jaguarundi (Puma yagouaroundi), and a black-eared opossum (Didelphis aurita) from Brazil. Vet Parasitol 2011, 175:377-81.
  • [28]Alvarado-Esquivel C, Sifuentes-Alvarez A, Narro-Duarte SG, Estrada-Martínez S, Díaz-García JH, Liesenfeld O, et al.: Seroepidemiology of Toxoplasma gondii infection in pregnant women in a public hospital in northern Mexico. BMC Infect Dis 2006, 6:113. BioMed Central Full Text
  • [29]Alvarado-Esquivel C, Torres-Castorena A, Liesenfeld O, García-López CR, Estrada-Martínez S, Sifuentes-Alvarez A, et al.: Seroepidemiology of Toxoplasma gondii infection in pregnant women in rural Durango, Mexico. J Parasitol 2009, 95:271-4.
  • [30]Arling TA, Yolken RH, Lapidus M, Langenberg P, Dickerson FB, Zimmerman SA, et al.: Toxoplasma gondii antibody titers and history of suicide attempts in patients with recurrent mood disorders. J Nerv Ment Dis 2009, 197:905-8.
  • [31]Yagmur F, Yazar S, Temel HO, Cavusoglu M: May Toxoplasma gondii increase suicide attempt-preliminary results in Turkish subjects? Forensic Sci Int 2010, 199:15-7.
  • [32]Alvarado-Esquivel C, Sánchez-Anguiano LF, Arnaud-Gil CA, López-Longoria JC, Molina-Espinoza LF, Estrada-Martínez S, et al.: Toxoplasma gondii infection and suicide attempts: a case-control study in psychiatric outpatients. J Nerv Ment Dis 2013, 201:948-52.
  • [33]Xiao J, Li Y, Prandovszky E, Karuppagounder SS, Talbot CC Jr, Dawson VL, et al.: MicroRNA-132 dysregulation in Toxoplasma gondii infection has implications for dopamine signaling pathway. Neuroscience 2014, 268:128-38.
  • [34]Vander Weele CM, Porter-Stransky KA, Mabrouk OS, Lovic V, Singer BF, Kennedy RT, et al.: Rapid dopamine transmission within the nucleus accumbens: Dramatic difference between morphine and oxycodone delivery. Eur J Neurosci 2014, 40:3041-54.
  • [35]Bloomfield MA, Morgan CJ, Kapur S, Curran HV, Howes OD: The link between dopamine function and apathy in cannabis users: an [18F]-DOPA PET imaging study. Psychopharmacology (Berl) 2014, 231:2251-9.
  • [36]Ryding E, Lindström M, Träskman-Bendz L: The role of dopamine and serotonin in suicidal behaviour and aggression. Prog Brain Res 2008, 172:307-15.
  • [37]Alvarado-Esquivel C, Sánchez-Anguiano LF, Arnaud-Gil CA, Hernández-Tinoco J, Molina-Espinoza LF, Rábago-Sánchez E: Socio-demographic, clinical and behavioral characteristics associated with a history of suicide attempts among psychiatric outpatients: a case control study in a northern Mexican City. Int J Biomed Sci 2014, 10:61-8.
  • [38]Flegr J, Prandota J, Sovičková M, Israili ZH: Toxoplasmosis--a global threat: correlation of latent toxoplasmosis with specific disease burden in a set of 88 countries. PLoS One 2014, 9:e90203.
  • [39]Asberg M: Neurotransmitters and suicidal behavior: the evidence from cerebrospinal fluid studies. Ann N Y Acad Sci 1997, 836:158-81.
  • [40]Pandey GN: Biological basis of suicide and suicidal behavior. Bipolar Disord 2013, 15:524-41.
  • [41]Li JR, Gong RY, Li YP, Bai Y, You F, Deng S: Research on HIV/Toxoplasma gondii co-infection and cytokine levels among intravenous drug users. Parasite Immunol 2010, 32:161-4.
  • [42]Pfrepper KI, Enders G, Gohl M, Krczal D, Hlobil H, Wassenberg D, et al.: Seroreactivity to and avidity for recombinant antigens in toxoplasmosis. Clin Diagn Lab Immunol 2005, 12:977-82.
  • [43]Liesenfeld O, Press C, Montoya JG, Gill R, Isaac-Renton JL, Hedman K, et al.: False-positive results in immunoglobulin M (IgM) Toxoplasma antibody tests and importance of confirmatory testing: the Platelia Toxo IgM test. J Clin Microbiol 1997, 35:174-8.
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