MiR-146a rs2910164 G/C polymorphism and gastric cancer susceptibility: a meta-analysis

BMC Medical Genetics

Banjun Bai¹  Hui Cao²  Lingling Zhang¹  Zhong Xu¹ 

[1] Department of Gastroenterology, Guizhou Provincial People’s Hospital, The Affiliated People’s Hospital of Guiyang Medical University, Guiyang 550002, Guizhou Province, PR China;Department of Oncology, Guizhou Provincial People’s Hospital, The Affiliated People’s Hospital of Guiyang Medical University, Guiyang 550002, Guizhou Province, PR of China

关键词: Meta-analysis;    Polymorphism;    Stomach neoplasms;    microRNA-146a;   

Others  :  1090379
DOI  :  10.1186/s12881-014-0117-2

 received in 2014-03-27, accepted in 2014-10-10,  发布年份 2014

【 摘 要 】

Background

Evidence has shown that single nucleotide polymorphism located in pre-miRNA or mature microRNA may modify various biological processes and affect the processing of carcinogenesis. Published results about the association between miR-146a rs2910164 G/C polymorphism and human gastric cancer susceptibility are inconclusive. The aim of this study was to acquire a more precise effect of the association between the miR-146a rs2910164 polymorphism and gastric risk by meta-analysis.

Methods

Eligible genetic association studies were searched from PubMed, Web of Knowledge and Chinese Biomedicine Database on human subject. Quantitative data synthesis was conducted for the associations of miR-146a rs2910164 G/C polymorphism with susceptibility to gastric cancer.

Results

Nine eligible studies that included a total of 3,885 gastric cancer patients and 5,396 controls were identified in the present meta-analysis. The overall OR indicated a potential association between rs2910164 polymorphism and GC but the effect was not statistically significant (GG vs. CG/CC: OR = 1.076, 95% CI 0.925-1.251, P = 0.342). When stratifying for population, the result showed that miR-146a rs2910164 GG genotype was associated with increased gastric cancer risk among Chinese in recessive model (GG vs. CG/CC: OR = 1.171, 95% CI 1.050-1.306, P = 0.005). Besides, no significant difference was found in gender, smoking, location, metastasis of lymph node and Laurèn’s classification.

Conclusions

The present meta-analysis suggests an increased risk between miR-146a rs2910164 GG genotype and gastric cancer susceptibility in Chinese based on published literatures.

【 授权许可】

   
2014 Xu et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

Figure 3.

Figure 4.

Figure 5.

Figure 3.

【 参考文献 】

• [1]Siegel R, Naishadham D, Jemal A: Cancer statistics, 2013. CA Cancer J Clin 2013, 63:11-30.
• [2]Lin Y, Ueda J, Kikuchi S, Totsuka Y, Wei WQ, Qiao YL, Inoue M: Comparative epidemiology of gastric cancer between Japan and China. World J Gastroenterol 2011, 17:4421-4428.
• [3]Bartel DP, Chen CZ: Micromanagers of gene expression: the potentially widespread influence of metazoan microRNAs. Nat Rev Genet 2004, 5:396-400.
• [4]Bartel DP: MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 2004, 116:281-297.
• [5]Esquela-Kerscher A, Slack FJ: Oncomirs - microRNAs with a role in cancer. Nat Rev Cancer 2006, 6:259-269.
• [6]Costinean S, Zanesi N, Pekarsky Y, Tili E, Volinia S, Heerema N, Croce CM: Pre-B cell proliferation and lymphoblastic leukemia/high-grade lymphoma in E(mu)-miR155 transgenic mice. Proc Natl Acad Sci U S A 2006, 103:7024-7029.
• [7]Calin GA, Dumitru CD, Shimizu M, Bichi R, Zupo S, Noch E, Aldler H, Rattan S, Keating M, Rai K, Rassenti L, Kipps T, Negrini M, Bullrich F, Croce CM: Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. Proc Natl Acad Sci U S A 2002, 99:15524-15529.
• [8]Saunders MA, Liang H, Li WH: Human polymorphism at microRNAs and microRNA target sites. Proc Natl Acad Sci U S A 2007, 104:3300-3305.
• [9]Iwai N, Naraba H: Polymorphisms in human pre-miRNAs. Biochem Biophys Res Commun 2005, 331:1439-1444.
• [10]Lian H, Wang L, Zhang J: Increased risk of breast cancer associated with CC genotype of Has-miR-146a Rs2910164 polymorphism in Europeans. PLoS One 2012, 7:e31615.
• [11]Xu Y, Li L, Xiang X, Wang H, Cai W, Xie J, Han Y, Bao S, Xie Q: Three common functional polymorphisms in microRNA encoding genes in the susceptibility to hepatocellular carcinoma: a systematic review and meta-analysis. Gene 2013, 527:584-593.
• [12]Gao LB, Bai P, Pan XM, Jia J, Li LJ, Liang WB, Tang M, Zhang LS, Wei YG, Zhang L: The association between two polymorphisms in pre-miRNAs and breast cancer risk: a meta-analysis. Breast Cancer Res Treat 2011, 125:571-574.
• [13]Chen QH, Wang QB, Zhang B: Ethnicity modifies the association between functional microRNA polymorphisms and breast cancer risk: a HuGE meta-analysis. Tumour Biol 2013, 35:529-543.
• [14]Chen Z, Xu L, Ye X, Shen S, Li Z, Niu X, Lu S: Polymorphisms of microRNA sequences or binding sites and lung cancer: a meta-analysis and systematic review. PLoS One 2013, 8:e61008.
• [15]Srivastava K, Srivastava A: Comprehensive review of genetic association studies and meta-analyses on miRNA polymorphisms and cancer risk. PLoS One 2012, 7:e50966.
• [16]Wang J, Wang Q, Liu H, Shao N, Tan B, Zhang G, Wang K, Jia Y, Ma W, Wang N, Cheng Y: The association of miR-146a rs2910164 and miR-196a2 rs11614913 polymorphisms with cancer risk: a meta-analysis of 32 studies. Mutagenesis 2012, 27:779-788.
• [17]Wang F, Sun G, Zou Y, Fan L, Song B: Lack of association of miR-146a rs2910164 polymorphism with gastrointestinal cancers: evidence from 10206 subjects. PLoS One 2012, 7:e39623.
• [18]Wu D, Wang F, Dai WQ, He L, Lu J, Xu L, Guo CY: The miR-146a rs2910164 G > C polymorphism and susceptibility to digestive cancer in Chinese. Asian Pac J Cancer Prev 2013, 14:399-403.
• [19]Xu X, Yang X, Ru G, Wu Y, Zhang S, Xing C, Wu Y, Cao J: miR-146a gene polymorphism rs2910164 and the risk of digestive tumors: a meta-analysis of 21 case–control studies. Oncol Rep 2014, 31:472-479.
• [20]Higgins JP, Thompson SG: Quantifying heterogeneity in a meta-analysis. Stat Med 2002, 21:1539-1558.
• [21]Egger M, Davey Smith G, Schneider M, Minder C: Bias in meta-analysis detected by a simple, graphical test. BMJ (Clinical research ed) 1997, 315:629-634.
• [22]Begg CB, Mazumdar M: Operating characteristics of a rank correlation test for publication bias. Biometrics 1994, 50:1088-1101.
• [23]Okubo M, Tahara T, Shibata T, Yamashita H, Nakamura M, Yoshioka D, Yonemura J, Ishizuka T, Arisawa T, Hirata I: Association between common genetic variants in pre-microRNAs and gastric cancer risk in Japanese population. Helicobacter 2010, 15:524-531.
• [24]Zeng Y, Sun QM, Liu NN, Dong GH, Chen J, Yang L, Wang B: Correlation between pre-miR-146a C/G polymorphism and gastric cancer risk in Chinese population. World J Gastroenterol 2010, 16:3578-3583.
• [25]Hishida A, Matsuo K, Goto Y, Naito M, Wakai K, Tajima K, Hamajima N: Combined effect of miR-146a rs2910164 G/C polymorphism and Toll-like receptor 4 +3725 G/C polymorphism on the risk of severe gastric atrophy in Japanese. Dig Dis Sci 2011, 56:1131-1137.
• [26]Zhou F, Zhu H, Luo D, Wang M, Dong X, Hong Y, Lu B, Zhou Y, Zhou J, Zhang Z, Gong W: A functional polymorphism in Pre-miR-146a is associated with susceptibility to gastric cancer in a Chinese population. DNA Cell Biol 2012, 31:1290-1295.
• [27]Zhou Y, Du WD, Chen G, Ruan J, Xu S, Zhou FS, Zuo XB, Lv ZJ, Zhang XJ: Association analysis of genetic variants in microRNA networks and gastric cancer risk in a Chinese Han population. J Cancer Res Clin Oncol 2012, 138:939-945.
• [28]Ahn DH, Rah H, Choi YK, Jeon YJ, Min KT, Kwack K, Hong SP, Hwang SG, Kim NK: Association of the miR-146aC > G, miR-149T > C, miR-196a2T > C, and miR-499A > G polymorphisms with gastric cancer risk and survival in the Korean population. Mol Carcinog 2013, 52:39-51.
• [29]Dikeakos P, Theodoropoulos G, Rizos S, Tzanakis N, Zografos G, Gazouli M: Association of the miR-146aC > G, miR-149T > C, and miR-196a2T > C polymorphisms with gastric cancer risk and survival in the Greek population. Mol Biol Rep 2014, 41:1075-1080.
• [30]Kupcinskas J, Wex T, Link A, Leja M, Bruzaite I, Steponaitiene R, Juzenas S, Gyvyte U, Ivanauskas A, Ancans G, Petrenkiene V, Skieceviciene J, Kupcinskas L, Malfertheiner P: Gene polymorphisms of micrornas in helicobacter pylori-induced high risk atrophic gastritis and gastric cancer. PLoS One 2014, 9:e87467.
• [31]Pu J-Y, Dong W, Zhang L, Liang W-B, Yang Y, Lv M-L: No association between single nucleotide polymorphisms in pre-mirnas and the risk of gastric cancer in Chinese population. Iranian Journal of Basic Medical Sciences 2014, 17:128-133.
• [32]Okubo M, Tahara T, Shibata T, Yamashita H, Nakamura M, Yoshioka D, Yonemura J, Kamiya Y, Ishizuka T, Nakagawa Y, Nagasaka M, Iwata M, Arisawa T, Hirata I: Association between common genetic variants in pre-microRNAs and the clinicopathological characteristics and survival of gastric cancer patients. Experimental and Therapeutic Medicine 2010, 1:1035-1040.
• [33]Tobias A: Assessing the influence of a single study in the meta-analysis estimate. Stata Tech Bull 1999, 8:15-17.
• [34]Hou Z, Xie L, Yu L, Qian X, Liu B: MicroRNA-146a is down-regulated in gastric cancer and regulates cell proliferation and apoptosis. Med Oncol 2012, 29:886-892.
• [35]Paik JH, Jang JY, Jeon YK, Kim WY, Kim TM, Heo DS, Kim CW: MicroRNA-146a downregulates NFkappaB activity via targeting TRAF6 and functions as a tumor suppressor having strong prognostic implications in NK/T cell lymphoma. Clin Cancer Res 2011, 17:4761-4771.
• [36]Bhaumik D, Scott GK, Schokrpur S, Patil CK, Campisi J, Benz CC: Expression of microRNA-146 suppresses NF-kappaB activity with reduction of metastatic potential in breast cancer cells. Oncogene 2008, 27:5643-5647.
• [37]Hurst DR, Edmonds MD, Scott GK, Benz CC, Vaidya KS, Welch DR: Breast cancer metastasis suppressor 1 up-regulates miR-146, which suppresses breast cancer metastasis. Cancer Res 2009, 69:1279-1283.
• [38]Jazdzewski K, Murray EL, Franssila K, Jarzab B, Schoenberg DR, de la Chapelle A: Common SNP in pre-miR-146a decreases mature miR expression and predisposes to papillary thyroid carcinoma. Proc Natl Acad Sci U S A 2008, 105:7269-7274.
• [39]Xu W, Xu J, Liu S, Chen B, Wang X, Li Y, Qian Y, Zhao W, Wu J: Effects of common polymorphisms rs11614913 in miR-196a2 and rs2910164 in miR-146a on cancer susceptibility: a meta-analysis. PLoS One 2011, 6:e20471.
• [40]Qiu LX, He J, Wang MY, Zhang RX, Shi TY, Zhu ML, Mao C, Sun S, Lv FF, Zheng CL, Zhu XD: The association between common genetic variant of microRNA-146a and cancer susceptibility. Cytokine 2011, 56:695-698.
• [41]He B, Pan Y, Cho WC, Xu Y, Gu L, Nie Z, Chen L, Song G, Gao T, Li R, Wang S: The association between four genetic variants in microRNAs (rs11614913, rs2910164, rs3746444, rs2292832) and cancer risk: evidence from published studies. PLoS One 2012, 7:e49032.
• [42]Xu Y, Gu L, Pan Y, Li R, Gao T, Song G, Nie Z, Chen L, Wang S, He B: Different effects of three polymorphisms in MicroRNAs on cancer risk in Asian population: evidence from published literatures. PLoS One 2013, 8:e65123.
• [43]Yin Z, Yan L, Cui Z, Li X, Ren Y, Zhou B: Effects of common polymorphisms rs2910164 in miR-146a and rs3746444 in miR-499 on cancer susceptibility: a meta-analysis. Mol Biol Rep 2013, 40:3003-3013.
• [44]Song MY, Su HJ, Zhang L, Ma JL, Li JY, Pan KF, You WC: Genetic polymorphisms of miR-146a and miR-27a, H. pylori infection, and risk of gastric lesions in a Chinese population. PLoS One 2013, 8:e61250.