BMC Medical Genetics | |
MiR-146a rs2910164 G/C polymorphism and gastric cancer susceptibility: a meta-analysis | |
Banjun Bai1  Hui Cao2  Lingling Zhang1  Zhong Xu1  | |
[1] Department of Gastroenterology, Guizhou Provincial People’s Hospital, The Affiliated People’s Hospital of Guiyang Medical University, Guiyang 550002, Guizhou Province, PR China;Department of Oncology, Guizhou Provincial People’s Hospital, The Affiliated People’s Hospital of Guiyang Medical University, Guiyang 550002, Guizhou Province, PR of China | |
关键词: Meta-analysis; Polymorphism; Stomach neoplasms; microRNA-146a; | |
Others : 1090379 DOI : 10.1186/s12881-014-0117-2 |
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received in 2014-03-27, accepted in 2014-10-10, 发布年份 2014 | |
【 摘 要 】
Background
Evidence has shown that single nucleotide polymorphism located in pre-miRNA or mature microRNA may modify various biological processes and affect the processing of carcinogenesis. Published results about the association between miR-146a rs2910164 G/C polymorphism and human gastric cancer susceptibility are inconclusive. The aim of this study was to acquire a more precise effect of the association between the miR-146a rs2910164 polymorphism and gastric risk by meta-analysis.
Methods
Eligible genetic association studies were searched from PubMed, Web of Knowledge and Chinese Biomedicine Database on human subject. Quantitative data synthesis was conducted for the associations of miR-146a rs2910164 G/C polymorphism with susceptibility to gastric cancer.
Results
Nine eligible studies that included a total of 3,885 gastric cancer patients and 5,396 controls were identified in the present meta-analysis. The overall OR indicated a potential association between rs2910164 polymorphism and GC but the effect was not statistically significant (GG vs. CG/CC: OR = 1.076, 95% CI 0.925-1.251, P = 0.342). When stratifying for population, the result showed that miR-146a rs2910164 GG genotype was associated with increased gastric cancer risk among Chinese in recessive model (GG vs. CG/CC: OR = 1.171, 95% CI 1.050-1.306, P = 0.005). Besides, no significant difference was found in gender, smoking, location, metastasis of lymph node and Laurèn’s classification.
Conclusions
The present meta-analysis suggests an increased risk between miR-146a rs2910164 GG genotype and gastric cancer susceptibility in Chinese based on published literatures.
【 授权许可】
2014 Xu et al.; licensee BioMed Central Ltd.
【 预 览 】
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