BMC Public Health | |
The effect of 12 weeks of aerobic, resistance or combination exercise training on cardiovascular risk factors in the overweight and obese in a randomized trial | |
Sebely Pal2  Andrew P Hills1  Satvinder S Dhaliwal2  Suleen S Ho2  | |
[1] Mater Mother’s Hospital, Mater Medical Research Institute. Conjoint appointment with Griffith Health Institute, Griffith University, Brisbane, Australia;School of Public Health; Curtin Health Innovation Research Institute, Curtin University of Technology, GPO Box U1987, Perth, Western Australia, Australia, 6845 | |
关键词: Exercise training; Cardiovascular risk factors; Overweight; Obesity; | |
Others : 1163199 DOI : 10.1186/1471-2458-12-704 |
|
received in 2012-03-25, accepted in 2012-08-23, 发布年份 2012 | |
【 摘 要 】
Background
Evidence suggests that exercise training improves CVD risk factors. However, it is unclear whether health benefits are limited to aerobic training or if other exercise modalities such as resistance training or a combination are as effective or more effective in the overweight and obese. The aim of this study is to investigate whether 12 weeks of moderate-intensity aerobic, resistance, or combined exercise training would induce and sustain improvements in cardiovascular risk profile, weight and fat loss in overweight and obese adults compared to no exercise.
Methods
Twelve-week randomized parallel design examining the effects of different exercise regimes on fasting measures of lipids, glucose and insulin and changes in body weight, fat mass and dietary intake. Participants were randomized to either: Group 1 (Control, n = 16); Group 2 (Aerobic, n = 15); Group 3 (Resistance, n = 16); Group 4 (Combination, n = 17). Data was analysed using General Linear Model to assess the effects of the groups after adjusting for baseline values. Within-group data was analyzed with the paired t-test and between-group effects using post hoc comparisons.
Results
Significant improvements in body weight (−1.6%, p = 0.044) for the Combination group compared to Control and Resistance groups and total body fat compared to Control (−4.4%, p = 0.003) and Resistance (−3%, p = 0.041). Significant improvements in body fat percentage (−2.6%, p = 0.008), abdominal fat percentage (−2.8%, p = 0.034) and cardio-respiratory fitness (13.3%, p = 0.006) were seen in the Combination group compared to Control. Levels of ApoB48 were 32% lower in the Resistance group compared to Control (p = 0.04).
Conclusion
A 12-week training program comprising of resistance or combination exercise, at moderate-intensity for 30 min, five days/week resulted in improvements in the cardiovascular risk profile in overweight and obese participants compared to no exercise. From our observations, combination exercise gave greater benefits for weight loss, fat loss and cardio-respiratory fitness than aerobic and resistance training modalities. Therefore, combination exercise training should be recommended for overweight and obese adults in National Physical Activity Guidelines.
This clinical trial was registered with the Australian New Zealand Clinical Trials Registry (ANZCTR), registration number: ACTRN12609000684224.
【 授权许可】
2012 Ho et al.; licensee BioMed Central Ltd.
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
20150413093018989.pdf | 596KB | download | |
Figure 3. | 47KB | Image | download |
Figure 2. | 76KB | Image | download |
Figure 1. | 120KB | Image | download |
【 图 表 】
Figure 1.
Figure 2.
Figure 3.
【 参考文献 】
- [1]Physical Activity Guidelines Advisory Committee: Physical Activity Guidelines Advisory Committee Report. U.S. Department of Health and Human Services, Washington, DC; 2008.
- [2]National Health and Medical Research Council: National Physical Activity Guidelines for Australians. Australian Government Publishing Service, Canberra; 1999.
- [3]Slentz CA, Duscha BD, Johnson JL, Ketchum K, Aiken LB, Samsa GP, Houmard JA, Bales CW, Kraus WE: Effects of the amount of exercise on body weight, body composition, and measures of central obesity. Arch Intern Med 2004, 164:31-39.
- [4]Dumortier M, Brandou F, Perez-Martin A, Fedou C, Mercier J, Brun JF: Low intensity endurance exercise targeted for lipid oxidation improves body composition and insulin sensitivity in patients with the metabolic syndrome. Diabetes Metab 2003, 29:509-518.
- [5]Johnson JL, Slentz CA, Houmard JA, Samsa GP, Duscha BD, Aiken LB, McCartney JS, Tanner CJ, Kraus WE: Exercise training amount and intensity effects on metabolic syndrome (from Studies of a Targeted Risk Reduction Intervention through Defined Exercise). Am J Cardiol 2007, 100:1759-1766.
- [6]Sigal RJ, Kenny GP, Boulé NG, Wells GA, Prud’homme D, Fortler M, Reid RD, Tulloch H, Coyle D, Phillips P, et al.: Effects of aerobic training, resistance training, or both on glycemic control in type 2 diabetes. Ann Intern Med 2007, 147:357-369.
- [7]Davidson LE, Hudson R, Kilpatrick K, Kuk JL, McMillan K, Janiszewski PM, Lee S, Lam M, Ross R: Effects of exercise modality on insulin resistance and functional limitations in older adults. Archive of Internal Medicine 2009, 169(2):122-131.
- [8]Church TS, Blair SN, Cocreham S, Johannsen N, Johnson W, Kramer K, Mikus CR, Myers V, Nauta M, Rodarte RQ, et al.: Effects of aerobic and resistance training on hemoglobin A1c levels in patients with type 2 diabetes. J Am Med Assoc 2010, 304(20):2253-2262.
- [9]Randomization.com. http://www.randomization.com/ webcite
- [10]Karvonen MJ, Kentale E, Mustala O: The effects of training on heart rate: a longitudinal study. Ann Med Exp Biol Fenn 1957, 35(3):307-315.
- [11]Williams MA, Haskell WL, Ades PA, Amsterdam EA, Bittner V, Franklin BA, Gulanick M, Laing ST, Stewart KJ: Resistance exercise in individuals with and without cardiovascular disease: 2007 update: A scientific statement from the American Heart Association Council on clinical cardiology and council on nutrition, physical activity, and metabolism. Circulation 2007, 116:572-584.
- [12]Pal S, Khossousi A, Binns C, Dhaliwal S, Ellis V: The effect of a fibre supplement compared to a healthy diet on body composition, lipids, glucose, insulin and other metabolic syndrome risk factors in overweight and obese individuals. Br J Nutr 2011, 105:90-100.
- [13]Bairaktari E, Hatzidimou K, Tzallas C, Vini M, Katsaraki A, Tselepis A, Elisaf M, Tsolas O: Estimation of LDL cholesterol based on the Friedewald formula and on apo B levels. Clin Biochem 2000, 33(7):549-555.
- [14]Levy J, Matthews D, Hermans M: Correct homeostasis model assessment (HOMA) evaluation uses the computer program. Diabetes Care 1998, 21(12):2191-2192.
- [15]Zilversmit DB, Shea TM: Quantitation of apoB-48 and apoB-100 by gel scanning or radio-iodination. J Lipid Res 1989, 30(10):1639-1646.
- [16]Pal S, Ho N, Santos C, Dubois P, Mamo J, Croft K, Allister E: Red wine polyphenolics increase LDL receptor expression and activity and suppress the secretion of ApoB100 from human HepG2 cells. J Nutr 2003, 133:700-706.
- [17]Littlewood RA, White MS, Bell KL, Davies PSW, Cleghorn GJ, Grote R: Comparison of the Cosmed K4 b2 and the Deltatrac IITM metabolic cart in measuring resting energy expenditure in adults. Clin Nutr 2002, 21(6):491-497.
- [18]Mackinnon LT, Ritchie CB, Hooper SL, Abernethy PJ: Exercise Management: Concepts and Professional Practice. Human Kinetics, Champaign; 2003.
- [19]Ho SS, Dhaliwal SS, Hills A, Pal S: Acute exercise improves postprandial cardiovascular risk factors in overweight and obese individuals. Atherosclerosis 2011, 214(1):178-184.
- [20]Park DH, Ransone JW: Effects of submaximal exercise on high-density lipoprotein-cholesterol subfractions. Int J Sports Med 2003, 24(4):245-251.
- [21]O’Leary VB, Marchetti CM, Krishnan RK, Stetzer BP, Gonzalez F, Kirwan JP: Exercise-induced reversal of insulin resistance in obese elderly is associated with reduced visceral fat. J Appl Physiol 2006, 100:1584-1589.
- [22]Weiss EP, Racette SB, Villareal DT, Fontana L, Steger-May K, Schechtman KB, Klein S, Holloszy JO, Washington University School of Medicine CALERIE Group: Improvements in glucose tolerance and insulin action induced by increasing energy expenditure or decreasing energy intake: a randomized controlled trial. J Clin Nutr 2006, 84:1033-1042.
- [23]Sarsan A, Ardic F, Özgen M, Topuz O, Sermez Y: The effects of aerobic and resistance exercises in obese women. Clin Rehabil 2006, 20:773-782.
- [24]Polak J, Klimcakova E, Moro C, Viguerie N, Berlan M, Hejnova J, Richterova B, Kraus I, Langin D, Stich V: Effect of aerobic training on plasma levels and subcutaneous abdominal adipose tissue gene expression of adiponectin, leptin, interleukin 6, and tumor necrosis factor α in obese women. Metabolism Clinical and Experimental 2006, 55:1375-1381.
- [25]Haffner SM: Abdominal adiposity and cardiometabolic risk: do we have all the answers? Am J Med 2007, 120(9A):S10-17.
- [26]Kraus WE, Houmard JA, Duscha BD, Knetzger KJ, Wharton MB, McCartney JS, Bales CW, Henes S, Samsa G, Otvos JD, et al.: Effect of the amount and intensity of exercise on plasma lipoproteins. N Engl J Med 2002, 347:1483-1492.
- [27]Dietschy JM: Dietary fatty acids and the regulation of plasma low density lipoprotein cholesterol concentrations. J Nutr 1998, 28:444S-448S.
- [28]Treuth MS, Hunter GR, Weinsier RL, Kell SH: Energy expenditure and substrate utilization in older women after strength training: 24-h calorimeter results. J Appl Physiol 1995, 78(6):2140-2146.
- [29]Schutz Y, Tremblay A, Weinsier RL, Nelson KM: Role of fat oxidation in the long-term stabilization of body weight in obese women. Am J Clin Nutr 1992, 55:670-674.
- [30]Wei M, Kampert JB, Barlow CE, Nichaman MZ, Gibbons LW, Paffenbarger RS Jr, Blair SN: Relationship between low cardiorespiratory fitness and mortality in normal-weight, overweight, and obese men. J Am Med Assoc 1999, 282(16):1547-1553.
- [31]Gulati M, Pandey DK, Arnsdorf MF, Lauderdale DS, Thisted RA, Wicklund RH, Al-Hani AJ, Black HR: Exercise capacity and the risk of death in women: the St James Women Take Heart Study. Circulation 2003, 108:1554-1559.
- [32]LaMonte MJ, Blair SN: Physical activity, cardiorespiratory fitness, and adiposity: contributions to disease risk. Curr Opin Clin Nutr Metab Care 2006, 9(5):540-546.
- [33]Blake A, Miller WC, Brown DA: Adiposity does not hinder the fitness response to exercise training in obese women. J Sports Med Phys Fitness 2000, 40(2):170-177.
- [34]Ahmadizad S, Haghighi AH, Hamedinia MR: Effects of resistance versus endurance training on serum adiponectin and insulin resistance index. Eur J Endocrinol 2007, 157:635-631.
- [35]Achten J, Gleeson M, Jeukendrup AE: Determination of the exercise intensity that elicits maximal fat oxidation. Medicine & Science in Sports & Exercise 2002, 34(1):92-97.
- [36]Church TS, Earnest CP, Skinner JS, Blair SN: Effects of different doses of physical activity on cardiorespiratory fitness among sedentary, overweight or obese postmenopausal women with elevated blood pressure. J Am Med Assoc 2007, 297(19):2081-2091.
- [37]Australian Institute of Health and Welfare: Obesity trends in older Australians. In Bulletin No 12. Australian Institute of Health and Welfare, Canberra; 2004.
- [38]Ho SS, Radavelli-Bagatini S, Dhaliwal SS, Hills AP, Pal S: Resistance, Aerobic, and Combination Training on Vascular Function in Overweight and Obese Adults. J Clin Hypertens (Greenwich) 2012.