Antibacterial activities of selected edible plants extracts against multidrug-resistant Gram-negative bacteria

BMC Complementary and Alternative Medicine

Victor Kuete¹  Antoine HL Nkuete²  Simplice B Tankeo¹  Igor K Voukeng¹  Aimé G Fankam¹  Jackson A Seukep¹  Jaurès AK Noumedem¹  Doriane E Djeussi¹ 

[1] Department of Biochemistry, Faculty of Science, University of Dschang, Dschang, Cameroon;Department of Organic Chemistry, Faculty of Science, University of Dschang, Dschang, Cameroon

关键词: Dietary plants;    Multi-drug resistant bacteria;    Antibacterial;   

Others  :  1221082
DOI  :  10.1186/1472-6882-13-164

 received in 2013-03-22, accepted in 2013-07-08,  发布年份 2013

【 摘 要 】

Background

In response to the propagation of bacteria resistant to many antibiotics also called multi-drug resistant (MDR) bacteria, the discovery of new and more efficient antibacterial agents is primordial. The present study was aimed at evaluating the antibacterial activities of seven Cameroonian dietary plants (Adansonia digitata, Aframomum alboviolaceum, Aframomum polyanthum, Anonidium. mannii,Hibiscus sabdarifa, Ocimum gratissimum and Tamarindus indica).

Methods

The phytochemical screening of the studied extracts was performed using described methods whilst the liquid broth micro dilution was used for all antimicrobial assays against 27 Gram-negative bacteria.

Results

The results of the phytochemical tests indicate that all tested extracts contained phenols and triterpenes, other classes of chemicals being selectively present. The studied extracts displayed various degrees of antibacterial activities. The extracts of A. digitata, H. sabdarifa, A. polyanthum, A. alboviolaceum and O. gratissimum showed the best spectra of activity, their inhibitory effects being recorded against 81.48%, 66.66%, 62.96%, 55.55%, and 55.55% of the 27 tested bacteria respectively. The extract of A. polyanthum was very active against E. aerogenes EA294 with the lowest recorded minimal inhibitory concentration (MIC) of 32 μg/ml.

Conclusion

The results of the present work provide useful baseline information for the potential use of the studied edible plants in the fight against both sensitive and MDR phenotypes.

【 授权许可】

   
2013 Djeussi et al.; licensee BioMed Central Ltd.

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