Cardiorespiratory fitness, body mass index, and cancer mortality: a cohort study of Japanese men

BMC Public Health

Steven N Blair¹  Hiroaki Tanaka⁷  Takashi Muto²  Koji Tsukamoto⁵  Takashi Okamoto⁵  Masaaki Kanazawa⁵  Sataro Goto⁶  Ryo Kakigi⁶  Hisashi Naito⁶  I-Min Lee⁴  Susumu S Sawada³ 

[1] Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA;Department of Public Health, Dokkyo Medical University School of Medicine, Tochigi, Japan;Department of Health Promotion and Exercise, National Institute of Health and Nutrition, Tokyo, Japan;Division of Preventive Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA;Health Promotion Center, Tokyo Gas Co., Ltd., Tokyo, Japan;Department of Exercise Physiology, School of Health and Sports Science, Juntendo University, Chiba, Japan;Laboratory of Exercise Physiology, Faculty of Sports and Health Science, Fukuoka University, Fukuoka, Japan

关键词: Smoking;    Exercise;    Physical activity;    Maximal oxygen uptake;    Epidemiology;   

Others  :  1126540
DOI  :  10.1186/1471-2458-14-1012

 received in 2014-04-11, accepted in 2014-09-23,  发布年份 2014

【 摘 要 】

Background

The aim of this study is to investigate the independent and joint effects of cardiorespiratory fitness (CRF) and body mass index (BMI) on cancer mortality in a low body mass index population.

Methods

We evaluated CRF and BMI in relation to cancer mortality in 8760 Japanese men. The median BMI was 22.6 kg/m² (IQR: 21.0-24.3). The mean follow-up period was more than 20 years. Hazard ratios and 95% CI were obtained using a Cox proportional hazards model while adjusting for several confounding factors.

Results

Using the 2nd tertile of BMI (21.6-23.6 kg/m²) as reference, hazard ratios and 95% CI for the lowest tertile of BMI (18.5-21.5) were 1.26 (0.87–1.81), and 0.92 (0.64–1.34) for the highest tertile (23.7-37.4). Using the lowest tertile of CRF as reference, hazard ratios and 95% CIs for 2nd and highest tertiles of CRF were 0.78 (0.55–1.10) and 0.59 (0.40–0.88). We further calculated hazard ratios according to groups of men cross-tabulated by tertiles of CRF and BMI. Among men in the second tertile of BMI, those belonging to the lowest CRF tertile had a 53% lower risk of cancer mortality compared to those in the lowest CRF tertile (hazard ratio: 0.47, 95% CI: 0.23-0.97). Among those in the highest BMI tertile, the corresponding hazard ratio was 0.54 (0.25-1.17).

Conclusion

These results suggest that high CRF is associated with lower cancer mortality in a Japanese population of men with low average BMI.

【 授权许可】

   
2014 Sawada et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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