Polysaccharopeptide enhanced the anti-cancer effect of gamma-tocotrienol through activation of AMPK

BMC Complementary and Alternative Medicine

Ming-Tat Ling²  Terence Kin-Wah Lee³  Irene Oi-Lin Ng⁴  Jessica Lo⁴  Kai Dun Tang¹  Joan Yong¹  Jiezhong Chen⁵  Eunice Yuen-Ting Lau⁴  Ji Liu¹ 

[1] Australian Prostate Cancer Research Centre-Queensland & Institute of Health and Biomedical Innovation, Queensland University of Technology, Qld, Australia;Translational Research Institute, 37 Kent Street, Brisbane QLD 4102, Australia;Room 704, 7/F, Faculty of Medicine Building, 21 Sassoon Road, Hong Kong, SAR, China;Department of Pathology, Faculty of Medicine, the University of Hong Kong, Hong Kong, SAR, China;School of Biomedical Sciences, the University of Queensland, Qld, Australia

关键词: Prostate cancer;    AMPK;    Tocotrienol;    Polysaccharopeptide;   

Others  :  1086954
DOI  :  10.1186/1472-6882-14-303

 received in 2014-06-24, accepted in 2014-08-13,  发布年份 2014

【 摘 要 】

Background

Prostate cancer (PCa) frequently relapses after hormone ablation therapy. Unfortunately, once progressed to the castration resistant stage, the disease is regarded as incurable as prostate cancer cells are highly resistant to conventional chemotherapy.

Method

We recently reported that the two natural compounds polysaccharopeptide (PSP) and Gamma-tocotrienols (γ-T3) possessed potent anti-cancer activities through targeting of CSCs. In the present study, using both prostate cancer cell line and xenograft models, we seek to investigate the therapeutic potential of combining γ-T3 and PSP in the treatment of prostate cancer.

Result

We showed that in the presence of PSP, γ-T3 treatment induce a drastic activation of AMP-activated protein kinase (AMPK). This was accompanied with inactivation of acetyl-CoA carboxylase (ACC), as evidenced by the increased phosphorylation levels at Ser 79. In addition, PSP treatment also sensitized cancer cells toward γ-T3-induced cytotoxicity. Furthermore, we demonstrated for the first time that combination of PSP and γ-T3 treaments significantly reduced the growth of prostate tumor in vivo.

Conclusion

Our results indicate that PSP and γ-T3 treaments may have synergistic anti-cancer effect in vitro and in vivo, which warrants further investigation as a potential combination therapy for the treatment of cancer.

【 授权许可】

   
2014 Liu et al.; licensee BioMed Central Ltd.

【 图 表 】

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