The TCF7L2 rs7903146 polymorphism, dietary intakes and type 2 diabetes risk in an Algerian population

BMC Genetics

Aline Meirhaeghe⁵  Louisa Goumidi⁵  Leila Houti¹  Philippe Amouyel⁵  Nadhira Saidi-Mehtar⁴  Xavier Hermant⁵  Houssam Boulenouar⁴  Djabaria Naima Meroufel⁴  Imane Hamani-Medjaoui²  Sarah Aïcha Lardjam-Hetraf³  Sounnia Mediene-Benchekor³  Hadjira Ouhaibi-Djellouli³ 

[1] Laboratoire des Systèmes d’Information en Santé, Université d’Oran, Oran, Algeria;Caisse Nationale des Assurances Sociales des Travailleurs Salariés, Clinique Spécialisée en Orthopédie et Rééducation des Victimes des Accidents de Travail, Oran, Algeria;Département de Biotechnologie, Faculté des Sciences de la Nature et de la Vie, Université d’Oran, Oran, Algeria;Laboratoire de Génétique Moléculaire et Cellulaire, Université des Sciences et de la Technologie d’Oran Mohamed Boudiaf, Oran, Algeria;INSERM, U744; Institut Pasteur de Lille, Université de Lille, 1 rue du Pr. Calmette, Lille, F-59019, France

关键词: ISOR study;    TCF7L2;    Polymorphism;    Gene-diet interaction;    Diabetes;   

Others  :  1085096
DOI  :  10.1186/s12863-014-0134-3

 received in 2014-07-07, accepted in 2014-11-20,  发布年份 2014

【 摘 要 】

Background

The transcription factor 7-like 2 (TCF7L2) gene is the most significant genetic risk factor for type 2 diabetes (T2D). Association analyses were performed on participants (n = 751, aged between 30 and 64) in the ISOR population-based study in the city of Oran. Dietary intakes were estimated using a weekly food frequency questionnaire.

Results

The T allele of the rs7903146 single nucleotide polymorphism (SNP) was associated with lower body weight (p = 0.02), lower BMI (p = 0.009), lower waist circumference (p = 0.01) and a lower waist-to-hip ratio (p = 0.02). The T allele was associated with a significantly higher risk of T2D (odds ratio (OR) (95% confidence interval) = 1.55 (1.09–2.20), p = 0.01) and this association was independent of BMI. When considering the T2D risk, there were nominal interactions between the rs7903146 SNP and dessert (p = 0.05) and milk intakes (p = 0.01). The T2D risk was greater in T allele carriers with high dessert and milk intakes (OR = 2.61 (1.51-4.52), p = 0.0006, and 2.46 (1.47-4.12), p = 0.0006, respectively). In subjects with a high dessert intake, the T allele was also associated with higher fasting plasma glucose concentrations (4.89 ± 0.46 mmol/L in TT subjects, 4.72 ± 0.48 mmol/L in CT subjects and 4.78 ± 0.51 mmol/L in CC subjects; p = 0.03).

Conclusions

The T allele of the rs7903146 SNP is associated with a significantly higher risk of T2D in an Algerian population. This association was further strengthened by a high dessert intake, suggesting that gene-diet interactions increase the T2D risk.

【 授权许可】

   
2014 Ouhaibi-Djellouli et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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