Effect of Flabellaria paniculata Cav. extracts on gastric ulcer in rats

BMC Complementary and Alternative Medicine

Oluwole B Familoni³  Johnson A Olowe¹  Abidemi J Akindele⁴  Lilian Agufobi²  Margaret O Sofidiya² 

[1] Department of Physiology, Faculty of Basic Medical Sciences, College of Medicine, University of Lagos, Lagos, Nigeria;Department of Pharmacognosy, Faculty of Pharmacy, University of Lagos, Lagos, Nigeria;Department of Chemistry, Faculty of Science, University of Lagos, Lagos, Nigeria;Department of Pharmacology, Faculty of Basic Medical Sciences, College of Medicine, University of Lagos, Lagos, Nigeria

关键词: Acute toxicity;    Pylorus ligation-induced ulcer;    Indomethacin-induced ulcer;    Ethanol-induced ulcer;    Antiulcer;    Malphighiaceae;    Flabellaria paniculata Cav;   

Others  :  1231990
DOI  :  10.1186/1472-6882-12-168

 received in 2012-02-14, accepted in 2012-09-24,  发布年份 2012

【 摘 要 】

Background

The leaves and root of Flabellaria paniculata (Malpighiaceae) are frequently used in the treatment of wounds and ulcers in Nigerian folk medicine. The purpose of this study was to compare the effect of ethanolic extracts from the leaves (FPL) and root (FPR) of F. paniculata on gastric ulcers in rats.

Methods

The effect of FPL and FPR (100, 200 and 400 mg/kg) was evaluated in ethanol and indomethacin gastric ulcer models. Control groups for FPL and FPR were orally treated with 3% Tween 20 and distilled water respectively. FPL was further investigated in pylorus ligation model. Misoprostol and cimetidine were used as reference.

Results

FPL significantly (P < 0.05) reduced gastric lesions by 82.22% and 67.32% in ethanol and indomethacin induced ulcer models at 100 mg/kg respectively while FPR (100, 200 and 400 mg/kg) did not exert significant effect in the two models. In pylorus ligation model, FPL exerted a significant preventive antiulcer effect as indicated by reduction in gastric volume at 200 and 400 mg/kg doses. Only 400 mg/kg of the extract exerted a significant reduction in ulcer index when compared with the control group. The oral route LD₅₀ of FPL was estimated to be 4570 mg/kg while that of FPR was 2754 mg/kg. The LD₅₀ in intraperitoneal injection was estimated to be 1202.26 and 1380.38 mg/kg for FPL and FPR respectively. The phytochemical investigation showed that both extracts possess triterpenoids and saponin, while the presence of flavonoid was detected only in FPL.

Conclusions

The results of this study indicated that FPL and not FPR is effective against experimentally induced gastric ulcers. The presence of varied phytochemical constituents probably influenced the pharmacological differences between the two extracts.

【 授权许可】

   
2012 Sofidiya et al.; licensee BioMed Central Ltd.

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