期刊论文详细信息
BMC Complementary and Alternative Medicine
Alternative and antioxidant therapies used by a sample of infertile males in Jordan: a cross-sectional survey
Sanaa K Bardaweel1 
[1] Department of Pharmaceutical Sciences, Faculty of Pharmacy, The University of Jordan, Queen Rania Street, Amman 11942, Jordan
关键词: Medicinal plants;    Antioxidants;    Male infertility;    CAM;   
Others  :  1087341
DOI  :  10.1186/1472-6882-14-244
 received in 2014-01-13, accepted in 2014-06-30,  发布年份 2014
PDF
【 摘 要 】

Background

Complementary and alternative medicine (CAM) is frequently used in the Middle East, especially to treat chronic diseases such as infertility. We aimed to examine the prevalence, characteristics, and determinants of CAM use, particularly herbs and antioxidant therapies, among infertile males presenting for infertility evaluation in Jordan.

Methods

Demographic information, use of alternative and antioxidant therapies for infertility treatment, and patients’ belief in efficacy and safety of the therapies used were collected using a face-to-face questionnaire. Data were collected from 428 infertile male patients presenting at infertility clinics in Amman, the capital city of Jordan. The study was conducted between April 2013 and September 2013.

Results

Of the 428 men who completed the questionnaire, 184 (43%) used at least one of the alternative and antioxidant therapies specified in the questionnaire. Nutritional regime; vitamins, such as vitamins C and E; and medicinal herbs, such as ginger, saw palmetto, and ginseng were the most commonly used therapies reported. A correlation between the use of alternative and antioxidant therapies versus infertility duration was found. Additionally, the majority of males using CAM did not inform their health care providers about their usage.

Conclusions

The high prevalence of CAM use among infertile male patients underscores the urge to assimilate CAM into the education and training of health professionals, as well as to improve infertile patients’ knowledge of the safe use of CAM modalities.

【 授权许可】

   
2014 Bardaweel; licensee BioMed Central Ltd.

【 预 览 】
附件列表
Files Size Format View
20150116025229958.pdf 632KB PDF download
Figure 6. 42KB Image download
Figure 5. 54KB Image download
Figure 4. 32KB Image download
Figure 3. 21KB Image download
Figure 2. 46KB Image download
Figure 1. 32KB Image download
【 图 表 】

Figure 1.

Figure 2.

Figure 3.

Figure 4.

Figure 5.

Figure 6.

【 参考文献 】
  • [1]Evers J: Female subfertility. Lancet 2002, 360:151-159.
  • [2]Sharlip ID, Jarow JP, Belker AM, Lipshultz LI, Sigman M, Thomas AJ, Schlegel PN, Howards SS, Nehra A, Damewood MD, Overstreet JW, Sadovsky R: Best practice policies for male infertility. Fertil Steril 2002, 77:873-882.
  • [3]Bardaweel SK, Shehadeh M, Suaifan G, Kilani MVZ: Complementary and alternative medicine utilization by a sample of infertile couples in Jordan for infertility treatment: clinics-based survey. BMC Complement Altern Med 2013, 13:35-39.
  • [4]World Health Organization: WHO Laboratory Manual for the Examination of Human Semen and Semen-Cervical Mucus Interaction. 4th edition. Cambridge: Cambridge University Press; 1999:1-86.
  • [5]Agarwal A, Makker K, Sharma R: Clinical relevance of oxidative stress in male factor infertility: an update. Am J Reprod Immunol 2008, 59:2-11.
  • [6]Agarwal A, Sharma RK, Nallella KP, Thomas AJ Jr, Alvarez JG, Sikka SC: Reactive oxygen species as an independent marker of male factor infertility. Fertil Steril 2006, 86:878-885.
  • [7]de Lamirande E, Gagnon C: Impact of reactive oxygen species on spermatozoa: a balancing act between beneficial and detrimental effects. Hum Reprod 1995, 10:15-21.
  • [8]Agarwal A, Saleh RA: Role of oxidants in male infertility: rationale, significance, and treatment. Urol Clin North Am 2002, 29:817-827.
  • [9]Agarwal A, Said TM: Carnitines and male infertility. Reprod Biomed Online 2004, 8:376-384.
  • [10]Aitken RJ, De Iuliis GN: Origins and consequences of DNA damage in male germ cells. Reprod Biomed Online 2007, 14:727-733.
  • [11]Aitken RJ, Baker MA: Oxidative stress, sperm survival and fertility control. Mol Cell Endocrinol 2006, 250:66-69.
  • [12]Sikka SC: Relative impact of oxidative stress on male reproductive function. Curr Med Chem 2001, 8:851-862.
  • [13]Aziz N, Saleh RA, Sharma RK, Lewis-Jones I, Esfandiari N, Thomas AJ Jr, Agarwal A: Novel association between sperm reactive oxygen species production, sperm morphological defects, and the sperm deformity index. Fertil Steril 2004, 81:349-354.
  • [14]Alvarez JG, Storey BT: Differential incorporation of fatty acids into and peroxidative loss of fatty acids from phospholipids of human spermatozoa. Mol Reprod Dev 1995, 42:334-346.
  • [15]Drevet JR: The antioxidant glutathione peroxidase family and spermatozoa: a complex story. Mol Cell Endocrinol 2006, 250:70-79.
  • [16]Ebesunun MO, Solademi BA, Shittu OB, Anetor JI, Onuegbu JA, Olisekodiaka JM, Agbedana EO, Onyeaghala AA: Plasma and semen ascorbic levels in spermatogenesis. West Afr J Med 2004, 23:290-293.
  • [17]Rossato M, Mariotti C: Normal spermatogenesis and sperm function in a subject affected by cerebellar ataxia due to congenital vitamin E deficiency. Andrologia 2014, 46:322-324.
  • [18]Alvarez JG, Storey BT: Taurine, hypotaurine, epinephrine and albumin inhibit lipid peroxidation in rabbit spermatozoa and protect against loss of motility. Biol Reprod 1983, 29:548-555.
  • [19]Mancini A, Festa R, Silvestrini A, Nicolotti N, Di Donna V, La Torre G, Pontecorvi A, Meucci E: Hormonal regulation of total antioxidant capacity in seminal plasma. J Androl 2009, 30:534-540.
  • [20]Mancini A, De Marinis L, Littarru GP, Balercia G: An update of Coenzyme Q10 implications in male infertility: biochemical and therapeutic aspects. Biofactors 2005, 25:165-174.
  • [21]Health Quality Ontario: In vitro fertilization and multiple pregnancies: an evidence-based analysis. Ont Health Technol Assess Ser 2006, 6:1-63.
  • [22]Kamischke A, Nieschlag E: Analysis of medical treatment of male infertility. Hum Reprod 1999, 14:1-23.
  • [23]Showell MG, Brown J, Yazdani A, Stankiewicz MT, Hart RJ: Antioxidants for male subfertility. Cochrane Database Syst Rev 2011, 1:CD007411.
  • [24]Martin-Du Pan RC, Sakkas D: Are antioxidants useful in the treatment of male infertility? Hum Reprod 1998, 13:2984-2985.
  • [25]Agarwal A, Prabakaran S, Allamaneni SS: What an andrologist/urologist should know about free radicals and why. Urology 2006, 67:2-8.
  • [26]Jomova K, Valko M: Advances in metal-induced oxidative stress and human disease. Toxicology 2011, 283:65-87.
  • [27]Wroblewski N, Schill WB, Henkel R: Metal chelators change the human sperm motility pattern. Fertil Steril 2003, 79:1584-1589.
  • [28]Donnelly ET, McClure N, Lewis S: Antioxidant supplementation in vitro does not improve human sperm motility. Fertil Steril 1999, 72:484-495.
  • [29]Twigg J, Irvine DS, Houston P, Fulton N, Michael L, Aitken RJ: Iatrogenic DNA damage induced in human spermatozoa during sperm preparation: protective significance of seminal plasma. Mol Hum Reprod 1998, 4:439-445.
  • [30]Crimmel AS, Conner CS, Monga M: Withered Yang: a review of traditional Chinese medical treatment of male infertility and erectile dysfunction. J Androl 2001, 22:173-182.
  • [31]Gerhard I, Wallis E: Individualized homeopathic therapy for male infertility. Homeopathy 2002, 91:133-144.
  • [32]Ahmed RS, Seth V, Banerjee BD: Influence of dietary ginger (Zingiber officinales Rosc) on antioxidant defense system in rat: comparison with ascorbic acid. Indian J Exp Biol 2000, 38:604-606.
  • [33]Gerber GS: Saw palmetto for the treatment of men with lower urinary tract symptoms. J Urol 2000, 163:1408-1412.
  • [34]Gerber GS, Kuznetsov D, Johnson BC, Burstein JD: Randomized, double-blind, placebo-controlled trial of saw palmetto in men with lower urinary tract symptoms. Urology 2001, 58:960-964.
  • [35]Fu Y, Ji LL: Chronic ginseng consumption attenuates age-associated oxidative stress in rats. J Nutr 2003, 133:3603-3609.
  • [36]Hong B, Ji YH, Hong JH, Nam KY, Ahn TY: A double-blind crossover study evaluating the efficacy of Korean red ginseng in patients with erectile dysfunction: a preliminary report. J Urol 2002, 168:2070-2073.
  • [37]Murphy LL, Lee TJ: Ginseng, sex behavior, and nitric oxide. Ann N Y Acad Sci 2002, 962:372-377.
  • [38]Chen JC, Chen LD, Tsauer W, Tsai CC, Chen BC, Chen YJ: Effects of Ginsenoside Rb2 and Rc on inferior human sperm motility in vitro. Am J Chin Med 2001, 29:155-160.
  • [39]Tamler R, Mechanick JI: Dietary supplements and nutraceuticals in the management of andrologic disorders. Endocrinol Metab Clin North Am 2007, 36:533-552.
  文献评价指标  
  下载次数:42次 浏览次数:13次