Effective osteoporosis treatment with teriparatide is associated with enhanced quality of life in postmenopausal women with osteoporosis: the European Forsteo Observational Study

BMC Musculoskeletal Disorders

Fernando Marin¹  Dimitrios Karras⁴  Franz Jakob⁵  Gerald Rajzbaum³  Astrid Fahrleitner-Pammer²  J Bernard Walsh⁸  Willem F Lems⁶  Bente L Langdahl⁷  Ivaylo Stoykov¹  Annabel Barrett¹  Östen Ljunggren⁹ 

[1] Lilly Research Centre, Windlesham, UK;Medical University, Graz, Austria;Hôpital St. Joseph, Paris, France;Veterans Administration Hospital, Athens, Greece;Julius-Maximilians-Universitaet, Wuerzburg, Germany;VU University Medical Centre, Amsterdam, The Netherlands;Aarhus University Hospital, Aarhus, Denmark;Trinity College, Dublin, Ireland;Division of Endocrinology, Department of Medical Sciences, Uppsala University Hospital, Uppsala S-751 85, Sweden

关键词: Teriparatide;    Quality of life;    Osteoporosis;    Fracture;    EQ-5D;   

Others  :  1129874
DOI  :  10.1186/1471-2474-14-251

 received in 2013-04-18, accepted in 2013-07-30,  发布年份 2013

【 摘 要 】

Background

To describe changes in health-related quality of life (HRQoL) of postmenopausal women with osteoporosis treated with teriparatide for up to 18 months and followed-up for a further 18 months, and to assess the influence of recent prior and incident fractures.

Methods

The European Forsteo Observational Study (EFOS) is an observational, prospective, multinational study measuring HRQoL using the EQ-5D. The primary objective was to assess changes in HRQoL during 36 months in the whole study population. A secondary post-hoc analysis examined fracture impact on HRQoL in four subgroups classified based on recent prior fracture 12 months before baseline and incident clinical fractures during the study. Changes from baseline were analysed using a repeated measures model.

Results

Of the 1581 patients, 48.4% had a recent prior fracture and 15.6% of these patients had an incident fracture during follow-up. 10.9% of the 816 patients with no recent prior fracture had an incident fracture. Baseline mean EQ-VAS scores were similar across the subgroups. In the total study cohort (n = 1581), HRQoL (EQ-VAS and EQ-5D index scores) improved significantly from baseline to 18 months and this improvement was maintained over the 18-month post-teriparatide period. Improvements were seen across all five EQ-5D domains during teriparatide treatment that were maintained after teriparatide was discontinued. Subjects with incident clinical fractures had significantly less improvement in EQ-VAS than those without incident fractures. Recent prior fracture did not influence the change in EQ-VAS during treatment.

Conclusions

EFOS is the first longitudinal study in women with severe postmenopausal osteoporosis in the real world setting to show a substantial improvement in HRQoL during teriparatide treatment that was sustained during subsequent treatment with other medications. The increase in HRQoL was lower in the subgroups with incident fracture but was not influenced by recent prior fracture. The results should be interpreted in the context of the design of an observational study.

【 授权许可】

   
2013 Ljunggren et al.; licensee BioMed Central Ltd.

【 图 表 】

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