期刊论文详细信息
BMC Pulmonary Medicine
Patterns and determinants of COPD-related healthcare utilization by severity of airway obstruction in Korea
Youngsam Kim2  Jinhee Kim4  Sekyu Kim2  Yeonmok Oh3  Kyungwon Oh1  Jiye Jung2  Kyungjoo Kim5  Kyungsoo Chung2 
[1] Division of Health and Nutrition Survey, Korea Centers for Disease Control and Prevention, Osong, Chungcheongbuk-do, Republic of Korea;Division of Pulmonology, Department of Internal Medicine, The Institute of Chest Disease, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea;Department of Pulmonary and Critical Care Medicine, and Asthma Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea;Department of Nursing, College of Medicine, Chosun University, Gwangju, Republic of Korea;Yuhan Research Institute, Yongin, Gyeonggi-do, Republic of Korea
关键词: National health insurance claims;    Korean National Health and Nutritional Examination Survey;    Healthcare use;    Chronic obstructive lung disease;   
Others  :  1109602
DOI  :  10.1186/1471-2466-14-27
 received in 2013-03-08, accepted in 2014-02-19,  发布年份 2014
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【 摘 要 】

Background

We investigated patients with chronic obstructive pulmonary disease (COPD) to analyze patterns and identify determinants of healthcare use, according to the severity of airflow obstruction. We used retrospective cohort data from a combination of the 4th Korea National Health and Nutritional Examination Survey (KNHANES) and Korean National Health Insurance (NHI) claims.

Methods

Demographic and medical claims data were retrospectively analyzed from the 4th KNHANES along with NHI claims. Eligible patients were aged ≥40 years, who underwent complete pulmonary function tests (PFTs), and had at least one inpatient or outpatient claim coded as COPD between January 1, 2007 and December 31, 2010.

Results

Among 6,663 eligible participants, 897 (13.5%) had airway obstruction. Self-reported physician-diagnosed COPD comprised only 3%, and there were 870 undiagnosed COPD patients (97%). Self-reported physician-diagnosed asthma made up 3.7%. Of the 897 respondents, 244 (27.2%) used COPD-related healthcare services. The frequency of healthcare visits increased with increasing severity of airway obstruction. After a 3-year follow-up period, 646 (74.2% of those initially undiagnosed) remained undiagnosed and only 224 (25.8%) were diagnosed and treated for COPD. Only 27.5% of the 244 participants with airway obstruction who used COPD-related healthcare underwent PFTs during the study period. The percentage of prescribed medications associated with COPD increased in accordance with the severity of the COPD. Inhaled long-acting anticholinergics were prescribed for 10.9% of patients with moderate airway obstruction and for 52.4% of patients with severe obstruction. Inhaled long-acting β-agonists combined with corticosteroids were prescribed for 50% of patients with severe airway obstruction. Conversely, 44.6% of healthcare users were prescribed oral theophylline for COPD treatment, and 21.7% were also prescribed an oral corticosteroid. The determinants of COPD-associated healthcare use in respondents with obstructive lung disease were advanced age, severe airflow limitation, presence of comorbidities, and self-reported physician diagnosis of COPD.

Conclusions

This study ascertained marked underdiagnosed COPD. Although the percentage of prescribed medication used to treat COPD increased with the severity of the COPD, medications primarily prescribed such as oral theophylline or oral corticosteroids are inappropriate for first-line COPD treatment.

【 授权许可】

   
2014 Chung et al.; licensee BioMed Central Ltd.

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【 参考文献 】
  • [1]Decramer M, Janssens W, Miravitlles M: Chronic obstructive pulmonary disease. Lancet 2012, 379(9823):1341-1351.
  • [2]Mannino DM, Buist AS: Global burden of COPD: risk factors, prevalence, and future trends. Lancet 2007, 370(9589):765-773.
  • [3]Tan WC, Ng TP: COPD in Asia: where East meets West. Chest 2008, 133(2):517-527.
  • [4]Vestbo J, Hurd SS, Agustí AG, Jones PW, Vogelmeier C, Anzueto A, Barnes PJ, Fabbri LM, Martinez FJ, Nishimura M, Stockley RA, Sin DD, Rodriguez-Roisin R: Global strategy for the diagnosis, management and prevention of chronic obstructive pulmonary disease, GOLD executive summary. Am J Respir Crit Care Med 2012, 187(4):347-365.
  • [5]Bednarek M, Maciejewski J, Wozniak M, Kuca P, Zielinski J: Prevalence, severity and underdiagnosis of COPD in the primary care setting. Thorax 2008, 63(5):402-407.
  • [6]Soriano JB, Maier WC, Egger P, Visick G, Thakrar B, Sykes J, Pride NB: Recent trends in physician diagnosed COPD in women and men in the UK. Thorax 2000, 55(9):789-794.
  • [7]Chapman KR: Chronic obstructive pulmonary disease: are women more susceptible than men? Clin Chest Med 2004, 25(2):331-341.
  • [8]Pena VS, Miravitlles M, Gabriel R, Jimenez-Ruiz CA, Villasante C, Masa JF, Viejo JL, Fernandez-Fau L: Geographic variations in prevalence and underdiagnosis of COPD: results of the IBERPOC multicentre epidemiological study. Chest 2000, 118(4):981-989.
  • [9]Centers for Disease C, Prevention: Chronic obstructive pulmonary disease and associated health-care resource use - North Carolina, 2007 and 2009. MMWR 2012, 61(8):143-146.
  • [10]Fitch K, Iwasaki K, Pyenson B, Plauschinat C, Zhang J: Variation in adherence with global initiative for chronic obstructive lung disease (GOLD) drug therapy guidelines: a retrospective actuarial claims data analysis. Curr Med Res Opin 2011, 27(7):1425-1429.
  • [11]Joo MJ, Lee TA, Bartle B, van de Graaff WB, Weiss KB: Patterns of healthcare utilization by COPD severity: a pilot study. Lung 2008, 186(5):307-312.
  • [12]Pellegrino R, Viegi G, Brusasco V, Crapo RO, Burgos F, Casaburi R, Coates A, van der Grinten CP, Gustafsson P, Hankinson J, Jensen R, Johnson DC, Maclntyre N, McKay R, Miller MR, Navajas D, Pedersen OF, Wanger J: Interpretative strategies for lung function tests. Eur Respir J 2005, 26(5):948-968.
  • [13]Mapel DW, Dutro MP, Marton JP, Woodruff K, Make B: Identifying and characterizing COPD patients in US managed care. A retrospective, cross-sectional analysis of administrative claims data. BMC Health Serv Res 2011, 11:43. BioMed Central Full Text
  • [14]Blanchette CM, Broder M, Ory C, Chang E, Akazawa M, Dalal AA: Cost and utilization of COPD and asthma among insured adults in the US. Curr Med Res Opin 2009, 25(6):1385-1392.
  • [15]Jung JY, Kang YA, Park MS, Oh YM, Park EC, Kim HR, Lee SD, Kim SK, Chang J, Kim YS: Chronic obstructive lung disease-related health care utilisation in Korean adults with obstructive lung disease. Int J Tuberc Lung Dis 2011, 15(6):824-829.
  • [16]Mapel DW, McMillan GP, Frost FJ, Hurley JS, Picchi MA, Lydick E, Spencer MD: Predicting the costs of managing patients with chronic obstructive pulmonary disease. Resp Med 2005, 99(10):1325-1333.
  • [17]Halbert RJ, Natoli JL, Gano A, Badamgarav E, Buist AS, Mannino DM: Global burden of COPD: systematic review and meta-analysis. Eur Respir J 2006, 28(3):523-532.
  • [18]Menezes AM, Perez-Padilla R, Jardim JR, Muino A, Lopez MV, Valdivia G, de Oca Montes M, Talamo C, Hallal PC, Victora CG, PLATINO Team: Chronic obstructive pulmonary disease in five Latin American cities (the PLATINO study): a prevalence study. Lancet 2005, 366(9500):1875-1881.
  • [19]Buist AS, McBurnie MA, Vollmer WM, Gillespie S, Burney P, Mannino DM, Menezes AM, Sullivan SD, Lee TA, Weiss KB, Jensen RL, Marks GB, Gulsvik A, Nizankowska-Moqilnicka E, BOLD Collaborative Research Group: International variation in the prevalence of COPD (the BOLD Study): a population-based prevalence study. Lancet 2007, 370(9589):741-750.
  • [20]Coultas DB, Mapel D, Gagnon R, Lydick E: The health impact of undiagnosed airflow obstruction in a national sample of United States adults. Am J Respir Crit Care Med 2001, 164(3):372-377.
  • [21]Glaab T, Banik N, Rutschmann OT, Wencker M: National survey of guideline-compliant COPD management among pneumologists and primary care physicians. Copd 2006, 3(3):141-148.
  • [22]Decramer M, Bartsch P, Pauwels R, Yernault JC: Management of COPD according to guidelines. A national survey among Belgian physicians. Monaldi Arch Chest Dis 2003, 59(1):62-80.
  • [23]Cooke CE, Sidel M, Belletti DA, Fuhlbrigge AL: Review: clinical inertia in the management of chronic obstructive pulmonary disease. Copd 2012, 9(1):73-80.
  • [24]Mapel DW, Picchi MA, Hurley JS, Frost FJ, Petersen HV, Mapel VM, Coultas DB: Utilization in COPD: patient characteristics and diagnostic evaluation. Chest 2000, 117(5 Suppl 2):346S-353S.
  • [25]Soriano JB, Zielinski J, Price D: Screening for and early detection of chronic obstructive pulmonary disease. Lancet 2009, 374(9691):721-732.
  • [26]Kim DS, Kim YS, Jung KS, Chang JH, Lim CM, Lee JH, Uh ST, Shim JJ, Lew WJ, Korean Academy of Tuberculosis and Respiratory Diseases: Prevalence of chronic obstructive pulmonary disease in Korea: a population-based spirometry survey. Am J Respir Crit Care Med 2005, 172(7):842-847.
  • [27]Han MK, Kim MG, Mardon R, Renner P, Sullivan S, Diette GB, Martinez FJ: Spirometry utilization for COPD: how do we measure up? Chest 2007, 132(2):403-409.
  • [28]Heffner JE, Ellis R: The guideline approach to chronic obstructive pulmonary disease: how effective? Respir Care 2003, 48(12):1257-1266. discussion 1267–1258
  • [29]Seaman J, Leonard AC, Panos RJ: Health care utilization history, GOLD guidelines, and respiratory medication prescriptions in patients with COPD. Int J Chron Obstruct Pulmon Dis 2010, 5:89-97.
  • [30]Barr RG, Celli BR, Martinez FJ, Ries AL, Rennard SI, Reilly JJ Jr, Sciurba FC, Thomashow BM, Wise RA: Physician and patient perceptions in COPD: the COPD resource network needs assessment survey. Am J Med 2005, 118(12):1415.
  • [31]Park MJ, Choi CW, Kim SJ, Kim YK, Lee SY, Kang KH, Shin KC, Lee KH, Lee JH, Kim YI, Lim SC, Park YB, Jung KS, Kim TH, Shin DH, Yoo JH: Survey of COPD management among the primary care physicians in Korea. Tuberc Respir Dis 2008, 64(2):109-124.
  • [32]Simon-Tuval T, Scharf SM, Maimon N, Bernhard-Scharf BJ, Reuveni H, Tarasiuk A: Determinants of elevated healthcare utilization in patients with COPD. Respir Res 2011, 12:7. BioMed Central Full Text
  • [33]Vestbo J, Rasmussen FV: Respiratory symptoms and FEV1 as predictors of hospitalization and medication in the following 12 years due to respiratory disease. Eur Respir J 1989, 2(8):710-715.
  • [34]O’Reilly JF, Williams AE, Holt K, Rice L: Defining COPD exacerbations: impact on estimation of incidence and burden in primary care. Prim Care Respir J 2006, 15(6):346-353.
  • [35]Hilleman DE, Dewan N, Malesker M, Friedman M: Pharmacoeconomic evaluation of COPD. Chest 2000, 118(5):1278-1285.
  • [36]Hardie JA, Buist AS, Vollmer WM, Ellingsen I, Bakke PS, Morkve O: Risk of over-diagnosis of COPD in asymptomatic elderly never-smokers. Eur Respir J 2002, 20(5):1117-1122.
  • [37]Hanania NA, Mannino DM, Yawn BP, Mapel DW, Martinez FJ, Donohue JF, Kosinski M, Rendas-Baum R, Mintz M, Samuels S, Jhingran P, Dalal AA: Predicting risk of airflow obstruction in primary care: validation of the lung function questionnaire (LFQ). Resp Med 2010, 104(8):1160-1170.
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