Risk of cardiovascular events after initiation of long-acting bronchodilators in patients with chronic obstructive lung disease: A population-based study:

SAGE Open Medicine

AlmotasembellahAljaafareh¹ 

关键词: Chronic obstructive lung disease;    long-acting bronchodilators;    cardiovascular disease;    long-acting beta agonist;    long-acting muscarinic antagonist;    long-acting beta agonist-inhaled corticosteroids;   

DOI  :  10.1177/2050312116671337

学科分类：医学（综合）

来源: Sage Journals

【 摘 要 】

Objectives:Long-acting bronchodilators are mainstay treatment for moderate to severe chronic obstructive pulmonary disease. A growing body of evidence indicates an increased risk of cardiovascular events upon initiation of these medications. We hypothesize that this risk is higher in patients with chronic obstructive pulmonary disease who had a preexisting cardiovascular disease regardless of receipt of any cardiovascular medication.Methods:A retrospective cohort of patients with a diagnosis of chronic obstructive pulmonary disease based on two outpatient visits or one inpatient visit for chronic obstructive pulmonary disease (International Classification of Diseases, 9th Edition, Clinical Modification codes 491.x, 492.x, 496) in any year between 2001 and 2012 from a commercial insurance database. We then selected those initiating long-acting bronchodilator treatments between April 2001 and September 2012. Each patient had a 1 year look back period to determine history of cardiovascular disease or cardiov...

【 授权许可】

CC BY