Severe fever with thrombocytopenia syndrome in children: a case report

BMC Infectious Diseases

Wu-Chun Cao³  Wei Liu³  Hong-Yu Wang³  Ying Wo³  Qing-Bin Lu²  Ning Cui¹  Li-Yuan Wang³ 

[1] The 154 Hospital, People’s Liberation Army, Xinyang 464000, P. R. China;School of Public Health, Peking University, Beijing 100191, P. R. China;State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, P. R. China

关键词: Children;    Bunyavirus;    Severe fever with thrombocytopenia syndrome;   

Others  :  1127448
DOI  :  10.1186/1471-2334-14-366

 received in 2014-03-15, accepted in 2014-06-30,  发布年份 2014

【 摘 要 】

Background

Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by a novel bunyavirus (SFTSV) in China. Humans of all ages living in endemic areas have high risk of acquiring SFTS. Most clinical data so far have been from adults and no clinical study was available from children yet. The present study identified four SFTSV infected children through hospital based surveillance. A prospective observational study was performed to obtain their clinical and laboratory characteristics.

Case presentation

The patients’ age ranged from 4–15 years old and two were male. On hospitalization, fever, malaise and gastrointestinal syndromes were the most commonly presenting symptoms. Hemorrhagic symptoms or neurological manifestation was not recorded in any of the four pediatric patients. Hematological abnormalities at admission into hospital included leucopenia (4 cases), thrombocytopenia (1 case) and bicytopenia (1 case). The abnormal parameters included elevated aminotransferase (1 case), alanine transaminase (2 case), and lactate dehydrogenase (3 case). Laboratory parameters indicative of renal damage was not observed during the hospitalization. All the patients recovered well without sequelae being observed.

Conclusion

Compared with adults, pediatric patients with SFTSV infection seem to have less vague subjective complaints and less aggressive clinical course. Thrombocytopenia is suggested to be used less rigorously in recognizing SFTSV infection in pediatric patients, especially at early phase of disease.

【 授权许可】

   
2014 Wang et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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