Vitamin D status in non-supplemented postmenopausal Taiwanese women with osteoporosis and fragility fracture

BMC Musculoskeletal Disorders

Jung-Fu Chen⁴  Sharon Lei¹  Hung Jen Lai¹  Henrich Cheng⁶  Shu-Hua Yang²  Sheng-Mou Hou³  Ko-Hsiu Lu⁸  Shih-Te Tu⁵  Wen-Jer Chen⁷  Yuh-Min Cheng^1,11  Keh-Sung Tsai^1,10  Jawl-Shan Hwang⁹ 

[1] Medical Department, Merck Sharp & Dohme (I.A.) Corp. Taiwan Branch, Taipei, Taiwan;Department of Orthopaedic Surgery, National Taiwan University Hospital, Taipei, Taiwan;Department of Orthopedics, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan;Division of Endocrinology and Metabolism, Department of Internal Medicine, Chang Gung Memorial Hospital, Chang Gung University, 123, Ta-Pei Road, Niao-Sung Hsiang, Kaohsiung, Taiwan;Division of Endocrinology and Metabolism, Department of Internal Medicine, Changhua Christian Hospital, Changhua, Taiwan;Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan;Department of Orthopedics, Chang Gung Memorial Hospital, Chang Gung University, Linkou, Taiwan;Department of Orthopedics, Chung Shan Medical University Hospital, Taichung, Taiwan;Division of Endocrinology and Metabolism, Department of Internal Medicine, Chang Gung Memorial Hospital, Chang Gung University, Linkou, Taiwan;Department of Laboratory Medicine, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan;Department of Orthopaedic Surgery, Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung, Taiwan

关键词: Fracture;    Osteoporosis;    Vitamin D;   

Others  :  1122285
DOI  :  10.1186/1471-2474-15-257

 received in 2014-01-27, accepted in 2014-07-14,  发布年份 2014

【 摘 要 】

Background

Vitamin D is essential for calcium metabolism, Vitamin D deficiency can precipitate osteoporosis, cause muscle weakness and increase the risk of fracture. The aim of this study was to assess the prevalence of vitamin D inadequacy among non-supplemented postmenopausal women with osteoporosis and fragility fractures of the hip or vertebrae in Taiwan.

Methods

This multi-center, cross-sectional, observational study analyzed the vitamin D inadequacy [defined as 25(OH) D level less than 30 ng/mL] in Taiwanese postmenopausal osteoporotic patients who suffered from a low trauma, non-pathological fragility hip or vertebral fracture that received post-fracture medical care when admitted to hospital or at an outpatient clinic.

Results

A total of 199 patients were enrolled at 8 medical centers in Taiwan; 194 patients met the study criteria with 113 (58.2%) and 81 (41.8%) patients diagnosed with hip and vertebral fracture, respectively. The mean serum 25(OH) D level was 21.1 ± 9.3 ng/mL, resulting in a prevalence of vitamin D inadequacy of 86.6% of the patients.

Conclusions

High prevalence of vitamin D inadequacy across all age groups was found among non-supplemented women with osteoporosis and fragility hip or vertebral fracture in Taiwan.

【 授权许可】

   
2014 Hwang et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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