Comparative bactericidal activity of four fluoroquinolones against Pseudomonas aeruginosa isolated from chronic suppurative otitis media

BMC Ear, Nose and Throat Disorders

Takeshi Kusunoki²  Shigeki Misawa¹  Katsuhisa Ikeda² 

[1] Microbiology Laboratory, Juntendo University Faculty of Medicine, 2-1-1 Hongo, Bunkyo-ku 113-8421, Tokyo, Japan;Department of Otorhinolaryngology, Juntendo University Faculty of Medicine, 2-1-1 Hongo, Bunkyo-ku 113-8421, Tokyo, Japan

关键词: Minimum inhibitory concentration;    Bactericidal activity;    Chronic suppurative otitis media;    Pseudomonas aeruginosa;    Fluoroquinolone;   

Others  :  1230957
DOI  :  10.1186/s12901-015-0018-9

 received in 2015-04-17, accepted in 2015-10-05,  发布年份 2015

【 摘 要 】

Background

The aim of the present study was to evaluate the bactericidal activity of four new fluoroquinolones against current isolates of Pseudomonas aeruginosa from the patients with chronic suppurative otitis media (CSOM).

Methods

We examined bactericidal activity of four types of fluoroquinolones, garenoxacin (GRNX), levofloxacin (LVFX), ciprofloxacin (CPFX) and sitafloxacin (STFX) against current isolates of P. aeruginosa (50 strains).

Results

STFX exhibited the most potent activity of both MIC ₅₀and MIC ₉₀ , followed by CPFX, LVFX, and GRNX. The number of GRNX-resistant strains was significantly greater than those of LVFX, CPFX, and STFX (P < 0.05).

Conclusion

STFX showed the most potent activity against P. aeruginosa for recent pathogens recovered from CSOM as compared with the others, suggesting that the clinical application of topical STFX would be useful to prevent the emergence of resistant mutants of P. aeruginosa.

【 授权许可】

   
2015 Ikeda et al.

【 图 表 】

Fig. 1.

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