期刊论文详细信息
BMC Public Health
Multimorbidity and comorbidity in the Dutch population – data from general practices
Caroline A Baan3  François G Schellevis1  Robert A Verheij4  Christel E van Dijk4  Nancy Hoeymans2  Lidwien C Lemmens3  Boukje M van Gelder3  H Susan J Picavet3  Sandra H van Oostrom3 
[1] Department of General Practice/EMGO Institute, VU University Medical Centre, Amsterdam, the Netherlands;Centre for Public Health Forecasting, National Institute for Public Health and the Environment, P.O. Box 1, Bilthoven, 3720 BA, the Netherlands;Centre for Prevention and Health Services Research, National Institute for Public Health and the Environment, P.O. Box 1, Bilthoven 3720 BA, the Netherlands;Department of General Practice, Netherlands Institute for Health Services Research, P.O. Box 1568, Utrecht, 3500 BN, the Netherlands
关键词: Prevalence;    Epidemiology;    Chronic disease;    Comorbidity;    Multimorbidity;   
Others  :  1163181
DOI  :  10.1186/1471-2458-12-715
 received in 2012-03-05, accepted in 2012-08-10,  发布年份 2012
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【 摘 要 】

Background

Multimorbidity is increasingly recognized as a major public health challenge of modern societies. However, knowledge about the size of the population suffering from multimorbidity and the type of multimorbidity is scarce. The objective of this study was to present an overview of the prevalence of multimorbidity and comorbidity of chronic diseases in the Dutch population and to explore disease clustering and common comorbidities.

Methods

We used 7 years data (2002–2008) of a large Dutch representative network of general practices (212,902 patients). Multimorbidity was defined as having two or more out of 29 chronic diseases. The prevalence of multimorbidity was calculated for the total population and by sex and age group. For 10 prevalent diseases among patients of 55 years and older (N = 52,014) logistic regressions analyses were used to study disease clustering and descriptive analyses to explore common comorbid diseases.

Results

Multimorbidity of chronic diseases was found among 13% of the Dutch population and in 37% of those older than 55 years. Among patients over 55 years with a specific chronic disease more than two-thirds also had one or more other chronic diseases. Most disease pairs occurred more frequently than would be expected if diseases had been independent. Comorbidity was not limited to specific combinations of diseases; about 70% of those with a disease had one or more extra chronic diseases recorded which were not included in the top five of most common diseases.

Conclusion

Multimorbidity is common at all ages though increasing with age, with over two-thirds of those with chronic diseases and aged 55 years and older being recorded with multimorbidity. Comorbidity encompassed many different combinations of chronic diseases. Given the ageing population, multimorbidity and its consequences should be taken into account in the organization of care in order to avoid fragmented care, in medical research and healthcare policy.

【 授权许可】

   
2012 van Oostrom et al.; licensee BioMed Central Ltd.

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【 参考文献 】
  • [1]Fortin M, Soubhi H, Hudon C, Bayliss EA, van den Akker M: Multimorbidity's many challenges. BMJ 2007, 334(7602):1016-1017.
  • [2]Mercer SW, Smith SM, Wyke S, O'Dowd T, Watt GC: Multimorbidity in primary care: developing the research agenda. Fam Pract 2009, 26(2):79-80.
  • [3]Fortin M, Bravo G, Hudon C, Vanasse A, Lapointe L: Prevalence of multimorbidity among adults seen in family practice. Ann Fam Med 2005, 3(3):223-228.
  • [4]Laux G, Kuehlein T, Rosemann T, Szecsenyi J: Co- and multimorbidity patterns in primary care based on episodes of care: results from the German CONTENT project. BMC Health Serv Res 2008, 8:14. BioMed Central Full Text
  • [5]van den Akker M, Buntinx F, Metsemakers JF, Roos S, Knottnerus JA: Multimorbidity in general practice: prevalence, incidence, and determinants of co-occurring chronic and recurrent diseases. J Clin Epidemiol 1998, 51(5):367-375.
  • [6]Britt HC, Harrison CM, Miller GC, Knox SA: Prevalence and patterns of multimorbidity in Australia. Med J Aust 2008, 189(2):72-77.
  • [7]Uijen AA, van de Lisdonk EH: Multimorbidity in primary care: prevalence and trend over the last 20 years. Eur J Gen Pract 2008, 14:28-32.
  • [8]Marengoni A, Angleman S, Melis R, Mangialasche F, Karp A, Garmen A, Meinow B, Fratiglioni L: Aging with multimorbidity: A systematic review of the literature. Ageing Res Rev 2011, 10(4):430-439.
  • [9]Lehnert T, Heider D, Leicht H, Heinrich S, Corrieri S, Luppa M, Riedel-Heller S, Konig HH: Review: health care utilization and costs of elderly persons with multiple chronic conditions. Med Care Res Rev 2011, 68(4):387-420.
  • [10]Verheij RA, van Dijk CE, Abrahamse H, Davids R, van den Hoogen H, Braspenning J, van Althuis T: Landelijk Informatienetwerk Huisartsenzorg. Feiten en cijfers over huisartsenzorg in Nederland. (Netherlands Information Network of General Practice: facts and figures of general practice in the Netherlands). NIVEL/WOK, Utrecht/Nijmegen; 2009.
  • [11]Lamberts H, Wood M: The birth of the International Classification of Primary Care (ICPC). Serendipity at the border of Lac Leman. Fam Pract 2002, 19(5):433-435.
  • [12]An international glossary for general/family practice: WONCA Classification Committee. Fam Pract 1995, 12(3):341-369.
  • [13]Biermans MC, de Bakker DH, Verheij RA, Gravestein JV, van der Linden MW, de Vries Robbe PF: Development of a case-based system for grouping diagnoses in general practice. Int J Med Inform 2008, 77(7):431-439.
  • [14]Biermans MC, Verheij RA, de Bakker DH, Zielhuis GA, de Vries Robbe PF: Estimating morbidity rates from electronic medical records in general practice. Evaluation of a grouping system. Methods Inf Med 2008, 47(2):98-106.
  • [15]van den Akker M, Buntinx F, Knottnerus JA: Comorbidity or multimorbidity: what's in a name? A review of literature . Eur J Gen Pract 1996, 2(2):65-70.
  • [16]Feinstein AR: The pre-therapeutic classification of co-morbidity in chronic disease. J Chron Dis 1970, 23:455-468.
  • [17]The Family Medicine Research Centre: Defining chronic conditions for primary care using ICPC-2: supplementary data. University of Sydney, Sydney; 2004. http://www.fmrc.org.au/Download/DefiningChronicConditions.pdf webcite
  • [18]Gijsen R, Hoeymans N, Schellevis FG, Ruwaard D, Satariano WA, van den Bos GA: Causes and consequences of comorbidity: a review. J Clin Epidemiol 2001, 54(7):661-674.
  • [19]Fortin M, Bravo G, Hudon C, Lapointe L, Dubois MF, Almirall J: Psychological distress and multimorbidity in primary care. Ann Fam Med 2006, 4(5):417-422.
  • [20]Kadam UT, Croft PR: Clinical multimorbidity and physical function in older adults: a record and health status linkage study in general practice. Fam Pract 2007, 24(5):412-419.
  • [21]Schram MT, Frijters D, van de Lisdonk EH, Ploemacher J, de Craen AJ, de Waal MW, van Rooij FJ, Heeringa J, Hofman A, Deeg DJ, et al.: Setting and registry characteristics affect the prevalence and nature of multimorbidity in the elderly. J Clin Epidemiol 2008, 61(11):1104-1112.
  • [22]Huntley AL, Johnson R, Purdy S, Valderas JM, Salisbury C: Measures of multimorbidity and morbidity burden for use in primary care and community settings: a systematic review and guide. Ann Fam Med 2012, 10(2):134-141.
  • [23]Boyd CM, Fortin M: Future of multimorbidity research: how should understanding of multimorbidity inform health system design? Public Health Reviews 2010, 32(2):451-474.
  • [24]Fortin M, Stewart M, Poitras ME, Almirall J, Maddocks H: A systematic review of prevalence studies on multimorbidity: toward a more uniform methodology. Ann Fam Med 2012, 10(2):142-151.
  • [25]Wolff JL, Starfield B, Anderson G: Prevalence, expenditures, and complications of multiple chronic conditions in the elderly. Arch Intern Med 2002, 162(20):2269-2276.
  • [26]Salisbury C, Johnson L, Purdy S, Valderas JM, Montgomery AA: Epidemiology and impact of multimorbidity in primary care: a retrospective cohort study. Br J Gen Pract 2011, 61(582):e12-e21.
  • [27]Glynn LG, Valderas JM, Healy P, Burke E, Newell J, Gillespie P, Murphy AW: The prevalence of multimorbidity in primary care and its effect on health care utilization and cost. Fam Pract 2011, 28(5):516-523.
  • [28]Marengoni A, Rizzuto D, Wang HX, Winblad B, Fratiglioni L: Patterns of chronic multimorbidity in the elderly population. J Am Geriatr Soc 2009, 57(2):225-230.
  • [29]van den Bussche H, Koller D, Kolonko T, Hansen H, Wegscheider K, Glaeske G, von Leitner EC, Schafer I, Schon G: Which chronic diseases and disease combinations are specific to multimorbidity in the elderly? Results of a claims data based cross-sectional study in Germany. BMC Publ Health 2011, 11:101. BioMed Central Full Text
  • [30]Cornell JE, Pugh JA, Williams JW, Kazis L, Lee AFS, Parchman ML, Zeber J, Pederson T, Montgomery KA, Hitchcock P: Multimorbidity clusters: clustering binary data from multimorbidity clusters: clustering binary data from a large administrative medical database. Applied Multivariate Research 2007, 12(3):163-182.
  • [31]Garcia-Olmos L, Salvador CH, Alberquilla A, Lora D, Carmona M, Garcia-Sagredo P, Pascual M, Munoz A, Monteagudo JL, Garcia-Lopez F: Comorbidity patterns in patients with chronic diseases in general practice. PLoS One 2012, 7(2):e32141.
  • [32]Schafer I, Hansen H, Schon G, Maier W, Hofels S, Altiner A, Fuchs A, Gerlach FM, Petersen JJ, Gensichen J, et al.: The German MultiCare-study: Patterns of multimorbidity in primary health care - protocol of a prospective cohort study. BMC Health Serv Res 2009, 9:145. BioMed Central Full Text
  • [33]Fortin M, Contant E, Savard C, Hudon C, Poitras ME, Almirall J: Canadian guidelines for clinical practice: an analysis of their quality and relevance to the care of adults with comorbidity. BMC Fam Pract 2011, 12(1):74. BioMed Central Full Text
  • [34]van Weel C, Schellevis FG: Comorbidity and guidelines: conflicting interests. Lancet 2006, 367(9510):550-551.
  • [35]Smith SM, Soubhi H, Fortin M, Hudon C, O'Dowd T: Interventions for improving outcomes in patients with multimorbidity in primary care and community settings. Cochrane Database Syst Rev 2012, 4:CD006560.
  • [36]Boyd CM, Darer J, Boult C, Fried LP, Boult L, Wu AW: Clinical practice guidelines and quality of care for older patients with multiple comorbid diseases: implications for pay for performance. JAMA 2005, 294(6):716-724.
  • [37]Tinetti ME, Studenski SA: Comparative effectiveness research and patients with multiple chronic conditions. N Engl J Med 2011, 364(26):2478-2481.
  • [38]Ofman JJ, Badamgarav E, Henning JM, Knight K, Gano AD, Levan RK, Gur-Arie S, Richards MS, Hasselblad V, Weingarten SR: Does disease management improve clinical and economic outcomes in patients with chronic diseases? A systematic review. Am J Med 2004, 117(3):182-192.
  • [39]Greß S, Baan CA, Clanan M, Dedeu T, Groenewegen P, Howson H, Maroy L, Nolte E, Redaèlli M, Saarelma O, et al.: Co-ordination and management of chronic conditions in Europe: The role of primary care - Position paper of the European forum for primary care. Quality in Primary Care 2009, 17:75-86.
  • [40]Wagner EH, Bennett SM, Austin BT, Greene SM, Schaefer JK, Vonkorff M: Finding common ground: patient-centeredness and evidence-based chronic illness care. J Altern Complement Med 2005, 11(Suppl 1):S7-S15.
  • [41]Bodenheimer T: Disease management–promises and pitfalls. N Engl J Med 1999, 340(15):1202-1205.
  • [42]Boult C, Karm L, Groves C: Improving chronic care: the "guided care" model. Perm J 2008, 12(1):50-54.
  • [43]Boyd CM, Shadmi E, Conwell LJ, Griswold M, Leff B, Brager R, Sylvia M, Boult C: A pilot test of the effect of guided care on the quality of primary care experiences for multimorbid older adults. J Gen Intern Med 2008, 23(5):536-542.
  • [44]Starfield B, Lemke KW, Bernhardt T, Foldes SS, Forrest CB, Weiner JP: Comorbidity: implications for the importance of primary care in 'case' management. Ann Fam Med 2003, 1(1):8-14.
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