Does recurrent laryngeal nerve lymph node metastasis really affect the prognosis in node-positive patients with squamous cell carcinoma of the middle thoracic esophagus?

BMC Surgery

Mark J Krasna¹  Wei-Ming Mao²  Xing-Ming Zhou²  Qi-Xun Chen²  Jie Wu² 

[1] Meridian Cancer Care, Jersey Shore University Medical Center, Neptune, New Jersey, USA;Department of Thoarcic Surgery, Zhejinang Cancer Hospital, 38 Guangji Road, Hangzhou 310022, China

关键词: Squamous cell carcinoma;    Recurrent laryngeal nerve;    Lymph node metastasis;    Esophageal cancer;   

Others  :  863100
DOI  :  10.1186/1471-2482-14-43

 received in 2013-07-31, accepted in 2014-07-09,  发布年份 2014

【 摘 要 】

Background

Recurrent laryngeal nerve (RLN) lymph node metastasis used to be shown a predictor for poor prognosis in esophageal squamous cell carcinoma. The purpose of this study was to evaluate the prognostic impact of RLN node metastasis and the number of metastatic lymph nodes in node-positive patients with squamous cell carcinoma of middle thoracic esophagus.

Methods

A cohort of 235 patients who underwent curative surgery for squamous cell carcinoma of middle thoracic esophagus was investigated. The prognostic impact was evaluated by univariate and multivariate analyses.

Results

Lymph node metastasis was found in 133 patients. Among them, 81 had metastatic RLN nodes, and 52 had at least one positive node but no RLN nodal involvement. The most significant difference in survival was detected between patients with metastatic lymph nodes below and above a cutoff value of six (P < 0.001). Multivariate analysis revealed that the number of metastatic lymph nodes was a significant factor associated with overall survival (P < 0.001), but RLN lymph node metastasis was not (P = 0.865).

Conclusions

RLN Lymph node metastasis is not, but the number of metastatic nodes is a prognostic predictor in node-positive patients with squamous cell carcinoma of the middle thoracic esophagus.

【 授权许可】

   
2014 Wu et al.; licensee BioMed Central Ltd.

【 图 表 】

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