Vitamin D and tuberculosis: a multicenter study in children

BMC Infectious Diseases

Elena Chiappini²  Maurizio de Martino²  Luisa Galli²  Vas Novelli¹  Nuria Martinez-Alier³  Ludovica Facchini²  Elisabetta Venturini² 

[1] Department of Infectious Diseases, Great Ormond Street Hospital for Children NHS Trust, Great Ormond Street, London WC1N 3JH, UK;Department of Health Sciences, University of Florence, Anna Meyer Children’s University Hospital, viale Pieraccini 24, Florence, I-50139, Italy;Evelina London Children’s Hospital, Guy’s and St Thomas’ NHS Foundation Trust, London, UK

关键词: Children;    Tuberculosis;    Vitamin D;   

Others  :  1109874
DOI  :  10.1186/s12879-014-0652-7

 received in 2014-06-01, accepted in 2014-11-21,  发布年份 2014

【 摘 要 】

Background

The aim of this study is to evaluate vitamin D levels in children with latent and active TB compared to healthy controls of the same age and ethnical background.

Methods

A multicenter observational study has been conducted in three tertiary care paediatric centres: Anna Meyer Children's University Hospital, Florence, Italy; Evelina London Children's Hospital, London, United Kingdom and Great Ormond Street Hospital, London, United Kingdom. Vitamin D was considered deficient if the serum level was <25 nmol/L, insufficient between 25 and 50 nmol/L and sufficient for a level >50 nmol/L.

Results

The study population included 996 children screened for TB, which have been tested for vitamin D. Forty-four children (4.4%) had active TB, 138 (13.9%) latent TB and 814 (81.7%) were controls. Our study confirmed a high prevalence of hypovitaminosis D in the study population. A multivariate analysis confirmed an increased risk of hypovitaminosis D in children with latent and active TB compared to controls [(P = 0.018; RR = 1.61; 95% CI: 1.086-2.388), (P < 0.0001; RR = 4.587; 95% CI:1.190-9.608)].

Conclusions

Hypovitaminosis D was significantly associated with TB infection in our study. Further studies are needed to evaluate a possible role of vitamin D in the treatment and prevention of tuberculosis in children.

【 授权许可】

   
2014 Venturini et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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