BMC Psychiatry | |
A pilot study of the use of EEG-based synchronized Transcranial Magnetic Stimulation (sTMS) for treatment of Major Depression | |
Bill Phillips1  Yi Jin1  | |
[1] NeoSync, Inc., 4019 Westerly Pl., #201, Newport Beach, CA 92660, USA | |
关键词: Depression; IAF; NEST; rTMS; MDD; sTMS; | |
Others : 1123831 DOI : 10.1186/1471-244X-14-13 |
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received in 2012-09-11, accepted in 2014-01-16, 发布年份 2014 | |
【 摘 要 】
Background
Repetitive Transcranial Magnetic Stimulation (rTMS) is an effective treatment for Major Depressive Disorder (MDD), and is based upon delivery of focal high-energy pulses of electromagnetic stimulation. We postulated that delivery of rTMS at the subject’s individual alpha frequency (synchronized TMS, or sTMS) would achieve efficacy with lower energy of stimulation. We developed a device that rotates neodymium cylindrical magnets at three locations along the midline above the subject’s scalp to impart low-energy, sinusoidal-waveform magnetic brain stimulation over a broad area, and performed this efficacy study.
Method
Fifty-two subjects with MDD were enrolled in a randomized, sham controlled, double-blind treatment study (Trial Registration: NCT01683019). Forty-six subjects were included in the final analysis. Most subjects received concurrent antidepressant medications that remained unchanged during the study. Subjects were randomized to three treatment groups: 1) active sTMS with a fixed frequency at the subject’s alpha frequency; 2) active sTMS with a random stimulus frequency that varied between 8 Hz and 13 Hz; and, 3) sham sTMS. 20 half-hour sTMS sessions were administered 5 days per week for 4 weeks.
Results
Subjects with either fixed or random frequency active sTMS had statistically significantly greater percentage reduction in depression severity compared to sham (48.5% vs. 19.3%, respectively; p = 0.001). No significant difference was found between fixed and random groups (p = 0.30). No significant side effects were reported.
Conclusions
These results suggest that sTMS may be an effective treatment for MDD.
【 授权许可】
2014 Jin and Phillips; licensee BioMed Central Ltd.
【 预 览 】
Files | Size | Format | View |
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20150216044809995.pdf | 546KB | download | |
Figure 3. | 42KB | Image | download |
Figure 2. | 85KB | Image | download |
Figure 1. | 102KB | Image | download |
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【 参考文献 】
- [1]Price JL, Drevets WC: Neural circuits underlying the pathophysiology of mood disorders. Trends Cogn Sci 2012, 16(1):61-71.
- [2]O’Reardon JP, et al.: Efficacy and safety of transcranial magnetic stimulation in the acute treatment of major depression: a multisite randomized controlled trial. Biol Psychiatry 2007, 62(11):1208-1216.
- [3]George MS, et al.: Daily left prefrontal transcranial magnetic stimulation therapy for major depressive disorder: a sham-controlled randomized trial. Arch Gen Psychiatry 2010, 67(5):507-516.
- [4]Thut G, et al.: Rhythmic TMS causes local entrainment of natural oscillatory signatures. Curr Biol 2011, 21(14):1176-1185.
- [5]Fuggetta G, Pavone EF, Fiaschi A, Manganotti P: Acute modulation of cortical oscillatory activities during short trains of high-frequency repetitive transcranial magnetic stimulation of the human motor cortex: a combined EEG and TMS study. Hum Brain Mapp 2008, 29(1):1-13.
- [6]Brignani D, Manganotti P, Rossini PM, Miniussi C: Modulation of cortical oscillatory activity during transcranial magnetic stimulation. Hum Brain Mapp 2008, 29(5):603-612.
- [7]Klimesch W, Sauseng P, Gerloff C: Enhancing cognitive performance with repetitive transcranial magnetic stimulation at human individual alpha frequency. Eur J Neurosci 2003, 17(5):1129-1133.
- [8]Paus T, Sipila PK, Strafella AP: Synchronization of neuronal activity in the human primary motor cortex by transcranial magnetic stimulation: an EEG study. J Neurophysiol 2001, 86(4):1983-1990.
- [9]Veniero D, Brignani D, Thut G, Miniussi C: Alpha-generation as basic response-signature to transcranial magnetic stimulation (TMS) targeting the human resting motor cortex: a TMS/EEG co-registration study. Psychophysiology 2011, 48(10):1381-1389.
- [10]Andrew F, Leuchter IA, Cook YJ, Phillips B: The relationship between brain oscillatory activity and therapeutic effectiveness of transcranial magnetic stimulation in the treatment of major depressive disorder. Front Hum Neurosci 2013, 7(37):1-12.
- [11]Hamilton M: “A rating scale for depression,”. J Neurol Neurosurg Psychiatry 1960, 23:56-62.