Common ALDH2 genetic variants predict development of hypertension in the SAPPHIRe prospective cohort: Gene-environmental interaction with alcohol consumption

BMC Cardiovascular Disorders

Lee-Ming Chuang³  Daria Mochly-Rosen⁴  Che-Hong Chen⁴  Po-Chu Lee⁷  Wei-Jei Lee²  Timothy Donlon⁵  Thomas Quertermous⁹  Chao A Hsiung⁶  Yi-Jen Hung⁸  Low-Tone Ho^1,11  I-Te Lee¹  Yen-Feng Chiu⁶  Yi-Cheng Chang^1,10 

[1] Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan;Department of Surgery, Min-Sheng Hospital, Taoyuan, Taiwan;Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei, Taiwan;Department of Chemical and Systems Biology, School of Medicine Stanford University, Stanford, CA, USA;Kuakini Medical Center, Honolulu, HI, USA;Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan;Department of General Surgery, National Taiwan University Hospital, Taipei, Taiwan;Division of Endocrinology & Metabolism, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan;Division of Cardiovascular Medicine, Falk Cardiovascular Research Building, Stanford University School of Medicine, Stanford, CA, USA;Genomics Research Center, Academia Sinica, Taipei, Taiwan;Faculty of Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan

关键词: Chinese;    SNP;    Hypertension;    ALDH2;   

Others  :  1084679
DOI  :  10.1186/1471-2261-12-58

 received in 2012-04-17, accepted in 2012-07-11,  发布年份 2012

【 摘 要 】

Background

Genetic variants near/within the ALDH2 gene encoding the mitochondrial aldehyde dehydrogenase 2 have been associated with blood pressure and hypertension in several case–control association studies in East Asian populations.

Methods

Three common tag single nucleotide polymorphisms (tagSNP) in the ALDH2 gene were genotyped in 1,134 subjects of Chinese origin from the Stanford Asia-Pacific Program for Hypertension and Insulin Resistance (SAPPHIRe) family cohort. We examined whether the ALDH2 SNP genotypes predicted the development of hypertension in the prospective SAPPHIRe cohort.

Results

Over an average follow-up period of 5.7 years, carriers homozygous for the rs2238152 T allele in the ALDH2 gene were more likely to progress to hypertension than were non-carriers (hazard ratio [HR], 2.88, 95% confidence interval [CI], 1.06-7.84, P = 0.03), corresponding to a population attributable risk of ~7.1%. The risk associated with the rs2238152 T allele were strongest in heavy/moderate alcohol drinkers and was reduced in non-drinkers, indicating an interaction between ALDH2 genetic variants and alcohol intake on the risk of hypertension (P for interaction = 0.04). The risk allele was associated with significantly lower ALDH2 gene expression levels in human adipose tissue.

Conclusion

ALDH2 genetic variants were associated with progression to hypertension in a prospective Chinese cohort. The association was modified by alcohol consumption.

【 授权许可】

   
2012 Chang et al.; licensee BioMed Central Ltd.

【 图 表 】

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