Family history of cancer, personal history of medical conditions and risk of oral cavity cancer in France: the ICARE study

BMC Cancer

Loredana Radoï³  Sophie Paget-Bailly³  Florence Guida⁵  Diane Cyr³  Gwenn Menvielle³  Annie Schmaus³  Matthieu Carton³  Sylvie Cénée⁵  Marie Sanchez⁵  Anne-Valérie Guizard²  Brigitte Trétarre⁴  Isabelle Stücker⁵  Danièle Luce¹ 

[1] Inserm U1085, Irset, Faculté de Médecine, Campus de Fouillole, BP 145, 97154 Pointe-à-Pitre, Guadeloupe French West Indies

[2] Calvados Cancer Registry, F-1400 Caen, France

[3] University Versailles St-Quentin, F-78035 Versailles, France

[4] Hérault Cancer Registry, F-34298 Montpellier, France

[5] University Paris-Sud, UMRS 1018, F-94807 Villejuif, France

关键词: Case–control study;    Risk factors;    Oral cavity cancer;    Medical conditions;    Family history;   

Others  :  859238
DOI  :  10.1186/1471-2407-13-560

 received in 2013-01-18, accepted in 2013-11-03,  发布年份 2013

【 摘 要 】

Background

The aim of this study was to evaluate the role of family history of cancer and personal history of other medical conditions in the aetiology of the oral cavity cancer in France.

Methods

We used data from 689 cases of oral cavity squamous cell carcinoma and 3481 controls included in a population-based case–control study, the ICARE study. Odds-ratios (ORs) associated with family history of cancer and personal medical conditions and their 95% confidence intervals (95% CI) were estimated by unconditional logistic regression and were adjusted for age, gender, area of residence, education, body mass index, tobacco smoking and alcohol drinking.

Results

Personal history of oral candidiasis was related to a significantly increased risk of oral cavity cancer (OR 5.0, 95% CI 2.1-12.1). History of head and neck cancers among the first-degree relatives was associated with an OR of 1.9 (95% CI 1.2-2.8). The risk increased with the number of first-degree relatives with head and neck cancer.

Conclusion

A family history of head and neck cancer is a marker of an increased risk of oral cavity cancer and should be taken into account to target prevention efforts and screening. Further studies are needed to clarify the association between oral cavity cancer and personal history of candidiasis.

【 授权许可】

   
2013 Radoï et al.; licensee BioMed Central Ltd.

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