Antidiabetic and antihyperlipidemic activity of Piper longum root aqueous extract in STZ induced diabetic rats

BMC Complementary and Alternative Medicine

Chippada Appa Rao¹  Malaka Venkateshwarulu Jyothi Kumar²  Thandaiah Krishna Tilak¹  Swapna Sirasanagandla¹  Ramesh Babu Kasetti³  Shaik Abdul Nabi¹ 

[1] Department of Biochemistry, Sri Venkateswara University, Tirupati, 517 502 A.P, India;Department of Biotechnology, Sri Venkateswara University, Tirupati, 517502, India;Research Biochemistry, L.V.Prasad Eye Institute, Hyderabad, 500034, India

关键词: Streptozotocin;    Piper longum;    Diabetes mellitus;    Antihyperlipidemic;    Antihypeglycemic;   

Others  :  1230981
DOI  :  10.1186/1472-6882-13-37

 received in 2012-07-06, accepted in 2013-02-12,  发布年份 2013

【 摘 要 】

Background

The available drugs for diabetes, Insulin or Oral hypoglycemic agents have one or more side effects. Search for new antidiabetic drugs with minimal or no side effects from medicinal plants is a challenge according to WHO recommendations. In this aspect, the present study was undertaken to evaluate the antihyperglycemic and antihyperlipidemic effects of Piper longum root aqueous extract (PlrAqe) in streptozotocin (STZ) induced diabetic rats.

Methods

Diabetes was induced in male Wister albino rats by intraperitoneal administration of STZ (50 mg/kg.b.w). Fasting blood glucose (FBG) levels were measured by glucose-oxidase & peroxidase reactive strips. Serum biochemical parameters such as glycosylated hemoglobin (HbA1c), total cholesterol (TC), triglycerides (TG), very low density lipoprotein (VLDL), low density lipoprotein (LDL) and high density lipoprotein (HDL) cholesterol were estimated. The activities of liver and kidney functional markers were measured. The statistical analysis of results was carried out using Student t-test and one-way analysis (ANOVA) followed by DMRT.

Results

During the short term study the aqueous extract at a dosage of 200 mg/kg.b.w was found to possess significant antidiabetic activity after 6 h of the treatment. The administration of aqueous extract at the same dose for 30 days in STZ induced diabetic rats resulted in a significant decrease in FBG levels with the corrections of diabetic dyslipidemia compared to untreated diabetic rats. There was a significant decrease in the activities of liver and renal functional markers in diabetic treated rats compared to untreated diabetic rats indicating the protective role of the aqueous extract against liver and kidney damage and its non-toxic property.

Conclusions

From the above results it is concluded that the plant extract is capable of managing hyperglycemia and complications of diabetes in STZ induced diabetic rats. Hence this plant may be considered as one of the potential sources for the isolation of new oral anti hypoglycemic agent(s).

【 授权许可】

   
2013 Nabi et al.; licensee BioMed Central Ltd.

【 图 表 】

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