Calcium and vitamin D intakes in children: a randomized controlled trial

BMC Pediatrics

Roberto Berni Canani⁵  Gianluca Terrin⁴  Antonella Esposito¹  Antonio Del Puente¹  Marcella Savoia²  Ludovica Leone³  Annalisa Passariello³  Anna Coruzzo³  Margherita Di Costanzo³  Rita Nocerino³  Vincenza Pezzella³  Linda Cosenza³ 

[1]Department of Clinical and Experimental Medicine, University of Naples “Federico II”, Naples, Italy

[2]Department of Biochemistry and Medical Biotechnologies, University of Naples “Federico II”, Naples, Italy

[3]Department of Pediatrics, University of Naples “Federico II”, Naples, Italy

[4]Department of Women Heath and Perinatal Medicine, University of Rome “La Sapienza”, Rome, Italy

[5]European Laboratory for the Investigation of Food Induced Diseases, University of Naples “Federico II”, Naples, Italy

关键词: Vitamin D deficiency;    Vitamin D supplement;    Nutritional intervention;    Bone metabolism;    VitD intake;    Ca²⁺ intake;    Pediatrics;    Dietary counseling;    25-hydroxyvitamin D;   

Others  :  1144831
DOI  :  10.1186/1471-2431-13-86

 received in 2012-09-24, accepted in 2013-05-15,  发布年份 2013

【 摘 要 】

Background

Calcium (Ca²⁺) and vitamin D (VitD) play an important role in child health. We evaluated the daily intake of Ca²⁺ and VitD in healthy children. Moreover, we demonstrate the efficacy of Ca²⁺ and VitD supplementation.

Methods

Daily Ca^{2 +} and VitD intake was evaluated in consecutive healthy children through a validated questionnaire. Subjects with <70% of dietary reference intakes (DRIs) of Ca²⁺ and VitD were invited to participate in a prospective randomized trial with 2 groups of nutritional intervention: Group 1, dietary counseling aiming to optimize daily Ca²⁺ and VitD intake plus administration of a commercially available Ca^{2 +} and VitD supplementation product; Group 2, dietary counseling alone. At the enrollment (T0) and after 4 months (T1) serum 25(OH) Vitamin D levels were assessed.

Results

We evaluated 150 healthy children (male 50%, mean age 10 years); at baseline a low VitD intake was observed in all subjects (median 0.79 μg/die, IQR 1.78; range 0.01-5.02); this condition was associated with Ca²⁺ intake <70% of the DRIs in 82 subjects (55%). At baseline serum 25(OH)D levels were low (<30 ng/ml) in all study subjects and after 4 months of nutritional intervention, a normalization of serum 25(OH)D levels (≥30 ng/ml) was observed in all children in Group 1 and in only one subject in Group 2 [Group 1: T1 33.8 ng/ml (IQR 2.5) vs Group 2: T1 24.5 ng/ml (IQR 5.2), p <0.001].

Conclusions

Adequate Ca²⁺ and VitD intakes are difficult to obtain through dietary counseling alone in pediatric subjects. Oral supplementation with of Ca²⁺ and VitD is a reliable strategy to prevent this condition.

Trial registration

The study was registered in Clinical Trials Protocol Registration System (ID number: NCT01638494).

【 授权许可】

   
2013 Cosenza et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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