Immunosenescence of the CD8 + T cell compartment is associated with HIV-infection, but only weakly reflects age-related processes of adipose tissue, metabolism, and muscle in antiretroviral therapy-treated HIV-infected patients and controls

BMC Immunology

Ove Andersen⁵  Janne Petersen¹  Frank Krieger Jensen³  Jens Henrik Henriksen²  Thomas Huneck Haupt⁴  Anne Langkilde⁴  Juliette Tavenier⁴ 

[1]Section of Biostatistics, Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Øster Farimagsgade 5, Copenhagen K., 1014, Denmark

[2]Department of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital, Hvidovre, Kettegård Alle 30, Hvidovre, DK-2650, Denmark

[3]Department of Radiology, Copenhagen University Hospital, Hvidovre, Kettegård Alle 30, Hvidovre, DK-2650, Denmark

[4]Optimed, Clinical Research Centre, Copenhagen University Hospital, Hvidovre, Kettegård Alle 30, Hvidovre, DK-2650, Denmark

[5]Department of Infectious Diseases, Copenhagen University Hospital, Hvidovre, Kettegård Alle 30, Hvidovre, DK-2650, Denmark

关键词: KLRG1;    PD-1;    HIV;    Ageing;    Immunosenescence;   

Others  :  1234099
DOI  :  10.1186/s12865-015-0136-6

 received in 2015-08-06, accepted in 2015-11-20,  发布年份 2015

【 摘 要 】

Background

Despite effective antiretroviral therapy (ART), HIV-infected patients exhibit systemic inflammation, early onset of age-related diseases, and features of immunosenescence. The role of inflammation in the development of age-related diseases is widely recognized. However, the role of immunosenescence is not well established. Studying immunosenescence in HIV-infection could give insight into its role in ageing processes. In this cross-sectional study, we aimed to investigate whether ART-treated HIV-infected patients exhibit immunosenescence; and whether immunosenescence is associated with age-related processes of inflammation, metabolism, adipose tissue, and muscle. T cell immunosenescence and exhaustion were assessed by flow cytometry analysis of CD8 ⁺ cells from 43 ART-treated HIV-infected patients (HIV ⁺ ) and ten Controls using markers of differentiation: CD27/CD28; maturation: CD27/CD45RA; senescence: killer cell lectin-like receptor G1 (KLRG1); and exhaustion: programmed death-1 (PD-1). Relationships between CD8 ⁺ T cell immunosenescence, exhaustion, and age-related processes were assessed using linear regressions.

Results

HIV-infection was strongly associated with more highly differentiated and mature CD8 ⁺ T cell phenotypes. PD-1 and KLRG1 expression did not differ between HIV ⁺and Controls, but depended on differentiation and maturation stages of the cells. CD8 ⁺ T cell maturation was associated with age. KLRG1 expression was associated with age, metabolic syndrome, visceral adipose tissue, and high muscle mass. PD-1 expression was not associated with age-related parameters.

Conclusions

HIV-infection strongly affected CD8 ⁺ T cell differentiation and maturation, whereas age-related processes were only weakly associated with immune parameters. Our findings suggest that, in contrast to inflammation, immunosenescence appears to be highly dependent on HIV-infection and is only to a small extent associated with age-related parameters in well-treated HIV-infection.

【 授权许可】

   
2015 Tavenier et al.

【 图 表 】

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