期刊论文详细信息
BMC Psychiatry
Step-down versus outpatient psychotherapeutic treatment for personality disorders: 6-year follow-up of the Ullevål personality project
Theresa Wilberg2  Sigmund Karterud1  Elfrida H Kvarstein1  Øyvind Urnes1  Geir Pedersen1  Merete S Johansen1  Benjamin Hummelen2  Anne Kamps3  Ole Klungsøyr2  Bjørnar T Antonsen1 
[1] Department of Personality Psychiatry, Clinic for Mental Health and Addiction, Oslo University Hospital, Oslo, Norway;Department of Research and Development, Clinic for Mental Health and Addiction, Oslo University Hospital, Oslo, Norway;Department of Psychiatry, Lovisenberg Diaconal hospital, Oslo, Norway
关键词: Long-term follow-up;    Level of care;    Psychotherapy;    Personality disorder;   
Others  :  1123628
DOI  :  10.1186/1471-244X-14-119
 received in 2013-08-20, accepted in 2014-04-10,  发布年份 2014
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【 摘 要 】

Background

Although psychotherapy is considered the treatment of choice for patients with personality disorders (PDs), there is no consensus about the optimal level of care for this group of patients. This study reports the results from the 6-year follow-up of the Ullevål Personality Project (UPP), a randomized clinical trial comparing outpatient individual psychotherapy with a long-term step-down treatment program that included a short-term day hospital treatment followed by combined group and individual psychotherapy.

Methods

The UPP included 113 patients with PDs. Outcome was evaluated after 8 months, 18 months, 3 years and 6 years and was based on a wide range of clinical measures, such as psychosocial functioning, interpersonal problems, symptom severity, and axis I and II diagnoses.

Results

At the 6-year follow-up, there were no statistically significant differences in outcome between the treatment groups. Effect sizes ranged from medium to large for all outcome variables in both treatment arms. However, patients in the outpatient group had a marked decline in psychosocial functioning during the period between the 3- and 6-year follow-ups; while psychosocial functioning continued to improve in the step-down group during the same period. This difference between groups was statistically significant.

Conclusions

The findings suggest that both hospital-based long-term step-down treatment and long-term outpatient individual psychotherapy may improve symptoms and psychosocial functioning in poorly functioning PD patients. Social and interpersonal functioning continued to improve in the step-down group during the post-treatment phase, indicating that longer-term changes were stimulated during treatment.

Trial registration

NCT00378248.

【 授权许可】

   
2014 Antonsen et al.; licensee BioMed Central Ltd.

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【 参考文献 】
  • [1]Ogrodniczuk JS: New directions in treatment research for personality disorders: effectiveness of different levels of care. Psychother Psychosom 2011, 80(2):65-69.
  • [2]Verheul R, Herbrink M: The efficacy of various modalities of psychotherapy for personality disorders: a systematic review of the evidence and clinical recommendations. Int Rev Psychiatry 2007, 19:25-38.
  • [3]Livesley J: Integrated therapy for complex cases of personality disorder. J Clin Psychol 2008, 64:207-221.
  • [4]Gunderson JG, Gratz KL, Neuhaus EC, Smith GW: Levels of Care in Treatment. In Textbook of Personality Disorders. 1st edition. Edited by Oldham JM, Skodol AE, Bender DS. Washington DC, USA: American Psychiatric Publishing, Inc; 2005:239-255.
  • [5]Stoffers JM, Vollm BA, Rucker G, Timmer A, Huband N, Lieb K: Psychological therapies for people with borderline personality disorder. Cochrane Database Syst Rev 2012, 8:CD005652.
  • [6]Ogrodniczuk JS, Piper WE: Day treatment for personality disorders: a review of research findings. Harv Rev Psychiatry 2001, 9:105-117.
  • [7]Bartak A, Andrea H, Spreeuwenberg MD, Thunnissen M, Ziegler UM, Dekker J, Bouvy F, Hamers EF, Meerman AM, Busschbach JJ, Verheul R, Stijnen T, Emmelkamp PM: Patients with cluster a personality disorders in psychotherapy: an effectiveness study. Psychother Psychosom 2011, 80:88-99.
  • [8]Bartak A, Andrea H, Spreeuwenberg MD, Ziegler UM, Dekker J, Rossum BV, Hamers EF, Scholte W, Aerts J, Busschbach JJ, Verheul R, Stijnen T, Emmelkamp PM: Effectiveness of outpatient, day hospital, and inpatient psychotherapeutic treatment for patients with cluster B personality disorders. Psychother Psychosom 2011, 80:28-38.
  • [9]Bartak A, Spreeuwenberg MD, Andrea H, Holleman L, Rijnierse P, Rossum BV, Hamers EF, Meerman AM, Aerts J, Busschbach JJ, Verheul R, Stijnen T, Emmelkamp PM: Effectiveness of different modalities of psychotherapeutic treatment for patients with cluster C personality disorders: results of a large prospective multicentre study. Psychother Psychosom 2010, 79:20-30.
  • [10]Chiesa M, Bateman A, Wilberg T, Friis S: Patients’ characteristics, outcome and cost-benefit of hospital-based treatment for patients with personality disorder: a comparison of three different programmes. Psychol Psychother 2002, 75(Pt 4):381-392.
  • [11]Karterud S, Wilberg T: From general day hospital treatment to specialized treatment programmes. Int Rev Psychiatry 2007, 19:39-49.
  • [12]Livesley WJ: Research trends and directions in the study of personality disorder. Psychiatr Clin North Am 2008, 31:545-559. ix
  • [13]Bateman A, Fonagy P: Effectiveness of partial hospitalization in the treatment of borderline personality disorder: a randomized controlled trial. Am J Psychiatry 1999, 156:1563-1569.
  • [14]Bateman A, Fonagy P: Treatment of borderline personality disorder with psychoanalytically oriented partial hospitalization: an 18-month follow-up. Am J Psychiatry 2001, 158:36-42.
  • [15]Bateman A, Fonagy P: 8-year follow-up of patients treated for borderline personality disorder: mentalization-based treatment versus treatment as usual. Am J Psychiatry 2008, 165:631-638.
  • [16]Chiesa M, Fonagy P: Prediction of medium-term outcome in cluster B personality disorder following residential and outpatient psychosocial treatment. Psychother Psychosom 2007, 76:347-353.
  • [17]Chiesa M, Fonagy P, Holmes J: Six-year follow-up of three treatment programs to personality disorder. J Pers Disord 2006, 20:493-509.
  • [18]Chiesa M, Fonagy P, Holmes J, Drahorad C: Residential versus community treatment of personality disorders: a comparative study of three treatment programs. Am J Psychiatry 2004, 161:1463-1470.
  • [19]Bateman A, Fonagy P: Randomized controlled trial of outpatient mentalization-based treatment versus structured clinical management for borderline personality disorder. Am J Psychiatry 2009, 166:1355-1364.
  • [20]Giesen-Bloo J, van Dyck R, Spinhoven P, van Tilburg W, Dirksen C, van Asselt T, Kremers I, Nadort M, Arntz A: Outpatient psychotherapy for borderline personality disorder: randomized trial of schema-focused therapy vs transference-focused psychotherapy. Arch Gen Psychiatry 2006, 63:649-658.
  • [21]Davidson KM, Tyrer P, Norrie J, Palmer SJ, Tyrer H: Cognitive therapy v. usual treatment for borderline personality disorder: prospective 6-year follow-up. Br J Psychiatry 2010, 197:456-462.
  • [22]Kvarstein EH, Karterud S: Large variations of global functioning over five years in treated patients with personality traits and disorders. J Pers Disord 2012, 26:141-161.
  • [23]Skodol AE, Gunderson JG, Shea MT, McGlashan TH, Morey LC, Sanislow CA, Bender DS, Grilo CM, Zanarini MC, Yen S, Pagano ME, Stout RL: The Collaborative Longitudinal Personality Disorders Study (CLPS): overview and implications. J Pers Disord 2005, 19:487-504.
  • [24]Zanarini MC, Frankenburg FR, Hennen J, Reich DB, Silk KR: The McLean Study of Adult Development (MSAD): overview and implications of the first six years of prospective follow-up. J Pers Disord 2005, 19:505-523.
  • [25]Zanarini MC, Frankenburg FR, Reich DB, Fitzmaurice G: The 10-year course of psychosocial functioning among patients with borderline personality disorder and axis II comparison subjects. Acta Psychiatr Scand 2010, 122:103-109.
  • [26]Arnevik E, Wilberg T, Urnes O, Johansen M, Monsen JT, Karterud S: Psychotherapy for personality disorders: short-term day hospital psychotherapy versus outpatient individual therapy - a randomized controlled study. Eur Psychiatry 2009, 24:71-78.
  • [27]Arnevik E, Wilberg T, Urnes O, Johansen M, Monsen JT, Karterud S: Psychotherapy for personality disorders: 18 months’ follow-up of the ulleval personality project. J Pers Disord 2010, 24:188-203.
  • [28]Gullestad FS, Wilberg T, Klungsoyr O, Johansen MS, Urnes O, Karterud S: Is treatment in a day hospital step-down program superior to outpatient individual psychotherapy for patients with personality disorders? 3- years follow-up of a randomized clinical trial comparing different treatment modalities. Psychother Res 2012, 22:426-441.
  • [29]Mundt JC, Marks IM, Shear MK, Greist JM, Marks IM, Shear MK, Greist JM: The work and social adjustment scale: a simple measure of impairment in functioning. Br J Psychiatry 2002, 180:461-464.
  • [30]Pedersen G, Hagtvet KA, Karterud S: Generalizability studies of the global assessment of functioning-split version. Compr Psychiatry 2007, 48:88-94.
  • [31]Perdersen G: Norwegian revised version of inventory of interpersonal problems- circumplex (IIP-C). Tidsskr Nor Laegeforen 2002, 39:25-34.
  • [32]Alden LE, Wiggins JS, Pincus AL: Construction of circumplex scales for the inventory of interpersonal problems. J Pers Assess 1990, 55:521-536.
  • [33]Derogatis LR: Misuse of the symptom checklist 90. Arch Gen Psychiatry 1983, 40:1152-1153.
  • [34]Groth-Marnat G: The handbook of psychological assessment. 2nd edition. New York: John Wiley & Sons; 1990.
  • [35]Sheehan DV, Lecrubier Y, Sheehan KH, Amorim P, Janavs J, Weiller E, Hergueta T, Baker R, Dunbar GC: The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J Clin Psychiatry 1998, 59(Suppl 20):22-33. quiz 34–57
  • [36]First MB, Gibbon M, Spitzer RL, William JBW, Benjamin LS: The Structural Clinical Interview for DSM- IV Axis II Personality Disorder (SCID-II.). Washington DC, USA: American Psychiatric Press; 1997.
  • [37]Bateman A, Fonagy P: Mentalization based treatment for borderline personality disorder. World Psychiatry 2010, 9:11-15.
  • [38]Chiesa M, Fonagy P, Gordon J: Community-based psychodynamic treatment of severe personality disorder: clinical description and naturalistic evaluation. J Psychiatr Pract 2009, 15:12-24.
  • [39]Chiesa M, Hanton R, Fonagy P: Clinical Associations of deliberate self-injury and its impact on the outcome of community-based and long term inpatient treatment for personality disorder. Psychother Psychosom 2011, 80:100-109.
  • [40]Clarkin JF, Levy KN, Lenzenweger MF, Kernberg OF: Evaluating three treatments for borderline personality disorder: a multiwave study. Am J Psychiatry 2007, 164:922-928.
  • [41]Linehan MM, Comtois KA, Murray AM, Brown MZ, Gallop RJ, Heard HL, Korslund KE, Tutek DA, Reynolds SK, Lindenboim N: Two-year randomized controlled trial and follow-up of dialectical behavior therapy vs therapy by experts for suicidal behaviors and borderline personality disorder. Arch Gen Psychiatry 2006, 63:757-766.
  • [42]McMain SF, Links PS, Gnam WH, Guimond T, Cardish RJ, Korman L, Streiner DL: A randomized trial of dialectical behavior therapy versus general psychiatric management for borderline personality disorder. Am J Psychiatry 2009, 166:1365-1374.
  • [43]Vinnars B, Barber JP, Noren K, Gallop R, Weinryb RM: Manualized supportive-expressive psychotherapy versus nonmanualized community-delivered psychodynamic therapy for patients with personality disorders: bridging efficacy and effectiveness. Am J Psychiatry 2005, 162:1933-1940.
  • [44]Kvarstein EH, Arnevik E, Halsteinli V, Rø FG, Karterud S, Wilberg T: Health service costs and clinical gains of psychotherapy for personality disorders: a randomized controlled trial of day-hospital-based step-down treatment versus outpatient treatment at a specialist practice. BMC Psychiatry 2013, 13:315. BioMed Central Full Text
  • [45]Hummelen B, Wilberg T, Karterud S: Interviews of female patients with borderline personality disorder who dropped out of group psychotherapy. Int J Group Psychother 2007, 57:67-91.
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