BMC Pediatrics | |
Pediatric non alcoholic fatty liver disease: more on novel treatment targets | |
Grazia Massa1  Maria Sangermano1  Cristina Pizza1  Marco Poeta1  Giulia Paolella1  Pietro Vajro1  | |
[1] Department of Medicine and Surgery, University of Salerno, Via S. Allende, 84081, Baronissi -Salerno, Italy | |
关键词: Therapy; Probiotics; Microbiota; Gut-liver axis; Children; Non alcoholic fatty liver disease; | |
Others : 1144680 DOI : 10.1186/1471-2431-13-109 |
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received in 2013-05-21, accepted in 2013-07-18, 发布年份 2013 | |
【 摘 要 】
The mainstay treatment of non alcoholic fatty liver disease (NAFLD) based on weight loss and/or lifestyle changes is most often unsuccessful at all ages, thus requiring the implementation of pharmacological strategies. Targeting insulin resistance and oxidative stress has recently proven unsatisfactory. Among a number of proposed innovative approaches targeting novel pathomechanisms, probiotics appear an interesting and reasonable option acting on gut-liver axis malfunction through the modulation of diet-driven, obesogenic, and inflammatory intestinal microbiota.
A combined multiple pharmacological therapy directed simultaneously towards novel and old pathomechanisms (including, e.g., insulin resistance, oxidative stress, gut-liver axis, apoptosis) along with lifestyle interventions however might be necessary both in adult and pediatric NAFLD therapy.
【 授权许可】
2013 Vajro et al.; licensee BioMed Central Ltd.
【 预 览 】
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20150330222954735.pdf | 108KB | download |
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