At the moment of occurrence of a fragility hip fracture, men have higher mechanical properties values in comparison with women

BMC Musculoskeletal Disorders

Helena Canhão²  Maria F Vaz¹  João E Fonseca²  Jacinto Monteiro³  Luís G Rosa¹  Pedro M Amaral⁵  Ana Rodrigues²  Joana Caetano-Lopes⁴  André Saraiva⁵  Miguel Lúcio⁵  Inês P Aleixo⁴  Ana C Vale⁵ 

[1]Departamento de Engenharia Mecânica, Instituto Superior Técnico, UL, Av. Rovisco Pais, Lisbon, Portugal

[2]Serviço de Reumatologia e Doenças Ósseas Metabólicas, Lisbon Academic Medical Centre, Lisbon, Portugal

[3]Serviço de Ortopedia, Hospital de Santa Maria, Lisbon, Portugal

[4]Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal

[5]Instituto de Ciência e Engenharia de Materiais e Superfícies, Instituto Superior Técnico, University of Lisbon, Av. Rovisco Pais, Lisbon, Portugal

关键词: Mechanical properties;    Compression;    Fragility fracture;    Osteoporosis;    Trabecular bone;   

Others  :  1129471
DOI  :  10.1186/1471-2474-14-295

 received in 2012-04-30, accepted in 2013-10-01,  发布年份 2013

【 摘 要 】

Background

It is well established that males have lower fracture risk in comparison with females, which suggests a higher bone resistance in men. The aim of our study was to find out if in older patients with hip fragility fractures, gender has also an impact on trabecular bone material behaviour, specifically to determine whether trabecular mechanical properties under compressive loading differ between men and women who suffered a fragility hip fracture.

Methods

Femoral epiphyses were consecutively collected during hip replacement surgery due to proximal femur fragility fracture. Trabecular bone cylinders were drilled and submitted to uniaxial compression tests and mechanical properties were assessed.

Results

Seventy-three patients, 55 women (mean age 81 years and standard deviation of 7 years) and 18 men (mean age 81 years and standard deviation of 8 years) were evaluated. The ultimate stress of trabecular bone was significantly higher in men than in women: the median values and the interquartile range (IQR) were respectively 8.04(5.35-10.90) MPa vs. 4.46(3.02-7.73) MPa, (p-value = 0.005). The same difference between male and female was observed in the Young’s modulus: 293.68(166.67-538.18) MPa vs. 174.26(73.07-322.28) MPa, (p-value = 0.028), and also in the energy to failure: 0.25(0.07-0.42) MJ/m³ vs. 0.11(0.05-0.25) MJ/m³, (p-value = 0.058). These differences were also verified after adjusting the analysis for age in a multivariate model analysis.

Conclusions

Our observations demonstrated that, even in a population who suffered a fragility hip fracture, men still have higher trabecular bone mechanical properties in comparison with women.

【 授权许可】

   
2013 Vale et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

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