Neurocognitive features in male patients with schizophrenia exhibiting serious violence: a case control study

Annals of General Psychiatry

Hiroko Kashiwagi¹  Noriomi Kuroki²  Satoru Ikezawa¹  Masateru Matsushita³  Masanori Ishikawa⁴  Kazuyuki Nakagome¹  Naotsugu Hirabayashi¹  Manabu Ikeda³ 

[1] National Center of Neurology and Psychiatry, Ogawa-Higashi, Kodaira, Tokyo, Japan

[2] Tokyo Metropolitan Matsuzawa Hospital, Kamikitazawa, Setagaya-ku, Tokyo, Japan

[3] Department of Neuropsychiatry, Faculty of Life Sciences, Kumamoto University, Kumamoto, Kumamoto, Japan

[4] Department of Psychiatry, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan

关键词: Working memory;    Executive function;    BACS;    Substance abuse;    Schizophrenia;    Serious violence;   

Others  :  1235039
DOI  :  10.1186/s12991-015-0086-7

 received in 2015-07-13, accepted in 2015-12-07,  发布年份 2015

【 摘 要 】

Background

The relationship between violence and neurocognitive function in schizophrenia is unclear. We examined the backgrounds and neurocognitive functions of violent and nonviolent patients with schizophrenia to identify factors associated with serious violence.

Methods

Thirty male patients with schizophrenia who were hospitalized after committing serious violent acts were compared with 24 hospitalized male patients with schizophrenia and no history of violence. We evaluated psychiatric symptoms using the Positive and Negative Syndrome Scale (PANSS) and neurocognitive functions using the Brief Assessment of Cognition in Schizophrenia (BACS)-Japanese version.

Results

Repeated-measures analyses of variance on BACS subcomponents z-scores showed that the violent and control groups had different neuropsychological profiles at trend level (p = 0.095). Post hoc analyses of variance indicated that the violent group had significantly better working memory and executive function than the control group. In post hoc ANOVAs also controlling for the effect of the presence of substance abuse on cognitive function, violent or nonviolent group had a significant main effect on executive function but not on working memory.

Conclusions

Patient with violent or non-violent schizophrenia have distinct neuropsychological profiles. These results may help develop improved psychosocial treatments.

【 授权许可】

   
2015 Kashiwagi et al.

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