The Relationship between the Occupational Exposure of Trichloroethylene and Kidney Cancer

Annals of Occupational and Environmental Medicine

Jaehoon Rho²  Kye-mook Yoo³  June-Hee Lee¹  Jaehyeok Ha⁴  Inah Kim¹ 

[1]Institutes for Occupational Health, Yonsei University College of Medicine, Seoul, Korea

[2]Department of Preventive Medicine, Yonsei University College of Medicine, Seoul, Korea

[3]Occupational Safety and Health Research Institute, Korea Occupational Safety and Health Agency, Ulsan, Korea

[4]Department of occupational health, Seoul National University Graduate School of Public Health, Seoul, Korea

关键词: Exposure;    Occupation;    Work-related;    Korea;    Kidney cancer;    Trichloroethylene;   

Others  :  790451
DOI  :  10.1186/2052-4374-26-12

 received in 2014-05-15, accepted in 2014-05-21,  发布年份 2014

【 摘 要 】

Trichloroethylene (TCE) has been widely used as a degreasing agent in many manufacturing industries. Recently, the International Agency for Research on Cancer presented “sufficient evidence” for the causal relationship between TCE and kidney cancer. The aim of this study was to review the epidemiologic evidences regarding the relationship between TCE exposure and kidney cancer in Korean work environments. The results from the cohort studies were inconsistent, but according to the meta-analysis and case–control studies, an increased risk for kidney cancer was present in the exposure group and the dose–response relationship could be identified using various measures of exposure. In Korea, TCE is a commonly used chemical for cleaning or degreasing processes by various manufacturers; average exposure levels of TCE vary widely. When occupational physicians evaluate work-relatedness kidney cancers, they must consider past exposure levels, which could be very high (>100 ppm in some cases) and associated with jobs, such as plating, cleaning, or degreasing. The exposure levels at a manual job could be higher than an automated job. The peak level of TCE could also be considered an important exposure-related variable due to the possibility of carcinogenesis associated with high TCE doses. This review could be a comprehensive reference for assessing work-related TCE exposure and kidney cancer in Korea.

【 授权许可】

   
2014 Kim et al.; licensee BioMed Central Ltd.

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