Disposable screen-printed sensors for determination of duloxetine hydrochloride

Chemistry Central Journal

Nawal A Alarfaj²  Reda A Ammar¹  Maha F El-Tohamy² 

[1] Department of Chemistry, Collage of Science, Al-Azhar University, Cairo, Egypt

[2] Department of Chemistry, College of Science, King Saud University, P.O. Box 22452, Riyadh 11495, Saudi Arabia

关键词: Pharmaceutical preparations;    Duloxetine hydrochloride;    Potentiometry;    Disposable screen printed carbon electrode;   

Others  :  788386
DOI  :  10.1186/1752-153X-6-6

 received in 2011-10-19, accepted in 2012-01-21,  发布年份 2012

【 摘 要 】

A screen-printed disposable electrode system for the determination of duloxetine hydrochloride (DL) was developed using screen-printing technology. Homemade printing has been characterized and optimized on the basis of effects of the modifier and plasticizers. The fabricated bi-electrode potentiometric strip containing both working and reference electrodes was used as duloxetine hydrochloride sensor. The proposed sensors worked satisfactorily in the concentration range from 1.0 × 10^-6-1.0 × 10^-2 mol L^-1 with detection limit reaching 5.0 × 10^-7 mol L^-1 and adequate shelf life of 6 months. The method is accurate, precise and economical. The proposed method has been applied successfully for the analysis of the drug in pure and in its dosage forms. In this method, there is no interference from any common pharmaceutical additives and diluents. Results of the analysis were validated statistically by recovery studies.

【 授权许可】

   
2010 Alarfaj et al

【 图 表 】

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