期刊论文详细信息
Behavioral and Brain Functions
Neuronal representation of stand and squat in the primary motor cortex of monkeys
Chaolin Ma1  Xuan Ma2  Hang Zhang1  Jiang Xu2  Jiping He2 
[1] Center for Neural Interface Design, School of Biological and Health Systems Engineering, Arizona State University, Tempe 85287, AZ, USA
[2] Neural Interface & Rehabilitation Technology Research Center, Huazhong University of Science and Technology, Wuhan 430074, China
关键词: Neuroprosthetics;    Lower limb movement;    Topographical information;    Single neuron recording;    Monkeys;   
Others  :  1172044
DOI  :  10.1186/s12993-015-0061-0
 received in 2014-05-28, accepted in 2015-03-26,  发布年份 2015
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【 摘 要 】

Background

Determining neuronal topographical information in the cerebral cortex is of fundamental importance for developing neuroprosthetics. Significant progress has been achieved in decoding hand voluntary movement with cortical neuronal activity in nonhuman primates. However, there are few successful reports in scientific literature for decoding lower limb voluntary movement with the cortical neuronal firing. We once reported an experimental system, which consists of a specially designed chair, a visually guided stand and squat task training paradigm and an acute neuron recording setup. With this system, we can record high quality cortical neuron activity to investigate the correlation between these neuronal signals and stand/squat movement.

Methods/results

In this research, we train two monkeys to perform the visually guided stand and squat task, and record neuronal activity in the vast areas targeted to M1 hind-limb region, at a distance of 1 mm. We find that 76.9% of recorded neurons (1230 out of 1598 neurons) showing task-firing modulation, including 294 (18.4%) during the pre-response window; 310 (19.4%) for standing up; 104 (6.5%) for the holding stand phase; and 205 (12.8%) during the sitting down. The distributions of different type neurons have a high degree of overlap. They are mainly ranged from +7.0 to 13 mm in the Posterior-Anterior dimension, and from +0.5 to 4.0 mm in Dosal-lateral dimension, very close to the midline, and just anterior of the central sulcus.

Conclusions/significance

The present study examines the neuronal activity related to lower limb voluntary movements in M1 and find topographical information of various neurons tuned to different stages of the stand and squat task. This work may contribute to understanding the fundamental principles of neural control of lower limb movements. Especially, the topographical information suggests us where to implant the chronic microelectrode arrays to harvest the most quantity and highest quality neurons related to lower limb movements, which may accelerate to develop cortically controlled lower limb neuroprosthetics for spinal cord injury subjects.

【 授权许可】

   
2015 Ma et al.; licensee BioMed Central.

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