Cancer incidence and mortality in Serbia 1999–2009

BMC Cancer

Jovan Mihajlović³  Petros Pechlivanoglou³  Marica Miladinov-Mikov²  Snežana Živković¹  Maarten J Postma³ 

[1] Department for prevention and control of non-communicable diseases, Center for Disease Prevention and Control, Institute of Public Health of Serbia “Dr Milan Jovanović-Batut”, Dr Subotića 5, 11000, Belgrade, Serbia

[2] Department of Epidemiology, Medical Faculty, University of Novi Sad, Hajduk Veljkova 3, 21000, Novi Sad, Serbia

[3] Department of PharmacoEpidemiology and PharmacoEconomics (PE2), University of Groningen, Antonius Deusinglaan 1, 9713, AV Groningen, The Netherlands

关键词: Comparison;    Serbia;    Mortality;    Incidence;    Cancer;   

Others  :  1079972
DOI  :  10.1186/1471-2407-13-18

 received in 2012-06-15, accepted in 2013-01-09,  发布年份 2013

【 摘 要 】

Background

Despite the increase in cancer incidence in the last years in Serbia, no nation-wide, population-based cancer epidemiology data have been reported. In this study cancer incidence and mortality rates for Serbia are presented using nation-wide data from two population-based cancer registries. These rates are additionally compared to European and global cancer epidemiology estimates. Finally, predictions on Serbian cancer incidence and mortality rates are provided.

Methods

Cancer incidence and mortality was collected from the cancer registries of Central Serbia and Vojvodina from 1999 to 2009. Using age-specific regression models, we estimated time trends and predictions for cancer incidence and mortality for the following five years (2010–2014). The comparison of Serbian with European and global cancer incidence/mortality rates, adjusted to the world population (ASR-W) was performed using Serbian population-based data and estimates from GLOBOCAN 2008.

Results

Increasing trends in both overall cancer incidence and mortality rates were identified for Serbia. In men, lung cancer showed the highest incidence (ASR-W 2009: 70.8/100,000), followed by colorectal (ASR-W 2009: 39.9/100,000), prostate (ASR-W 2009: 29.1/100,000) and bladder cancer (ASR-W 2009: 16.2/100,000). Breast cancer was the most common form of cancer in women (ASR-W 2009: 70.8/100,000) followed by cervical (ASR-W 2009: 25.5/100,000), colorectal (ASR-W 2009: 21.1/100,000) and lung cancer (ASR-W 2009: 19.4/100,000). Prostate and colorectal cancers have been significantly increasing over the last years in men, while this was also observed for breast cancer incidence and lung cancer mortality in women. In 2008 Serbia had the highest mortality rate from breast cancer (ASR-W 2008: 22.7/100,000), among all European countries while incidence and mortality of cervical, lung and colorectal cancer were well above European estimates.

Conclusion

Cancer incidence and mortality in Serbia has been generally increasing over the past years. For a number of cancer sites, incidence and mortality is alarmingly higher than in the majority of European regions. For this increasing trend to be controlled, the management of risk factors that are present among the Serbian population is necessary. Additionally, prevention and early diagnosis are areas where significant improvements could still be made.

【 授权许可】

   
2013 Mihajlovic et al.; licensee BioMed Central Ltd.

【 图 表 】

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【 参考文献 】

• [1]Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D: Global cancer statistics. CA Cancer J Clin 2011, 61(2):69-90.
• [2]Parkin DM, Laara E, Muir CS: Estimates of worldwide frequency of sixteen major cancers in 1980. Int J Cancer 1988, 41:184-197.
• [3]Parkin DM, Pisani P, Ferlay J: Estimates of worldwide incidence of eighteen major cancers in 1985. Int J Cancer 1993, 54:594-606.
• [4]Parkin DM, Pisani P, Ferlay J: Estimates of the worldwide incidence of twenty-five major cancers in 1990. Int J Cancer 1999, 80:827-841.
• [5]Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM: [http://globocan.iarc.fr] webciteGLOBOCAN 2008, cancer incidence and mortality worldwide: IARC CancerBase No. 10. Lyon: International Agency for Research on Cancer; 2010.
• [6]Miljuš D, Vukičević A, Živković S: Cancer incidence and mortality in central Serbia (1999–2007). Belgrade: Cancer Registry of Serbia, Institute of Public Health of Serbia “Dr Milan Jovanović-Batut”; 2010.
• [7]Stankov S, Stankov K: Descriptive epidemiology of breast cancer in Vojvodina. Breast 2011, 20(2):192-195.
• [8]Petrović V, Miladinov-Mikov M, Dugandžija T: Topographical analyses of lung cancer incidence and mortality in Vojvodina. Arch Oncol 2010, 18(3):71.
• [9]Vlajinac H, Šipetić-Grujičić S, Janković S, Marinković J, Kocev N, Marković-Denić L, Bjegović V: Burden of cancer in Serbia. Croat Med J 2006, 47:134-141.
• [10]Bray F, Parkin DM: Evaluation of data quality in the cancer registry: Principles and methods. Part I: Comparability, validity and timeliness. Eur J Cancer 2009, 45:747-755.
• [11]Bray F, Parkin DM: Evaluation of data quality in the cancer registry: principles and methods. Part II: completeness. Eur J Cancer 2009, 45:756-764.
• [12]World Health Organization: [http://www.who.int/classifications/icd/en/] webciteInternational classification of diseases and related health problems, 10th revision. Volume 1 edition.
• [13]Statistical Office of the Republic of Serbia[http://webrzs.stat.gov.rs/Website] webcite
• [14]Segi M: Cancer mortality for selected sites in 24 countries (1950–57). Sendai: Tohoku University School of Public Health; 1960.
• [15]Dyba T, Hakulinen T: Comparison of different approaches to incidence prediction based on simple interpolation techniques. Stat Med 2000, 19(13):1741-1752.
• [16]R Development Core Team: [http://www.R-project.org] webciteR: A language and environment for statistical computing. R Foundation for Statistical Computing. Austria: Vienna; 2009.
• [17]Ferlay J, Shin HR, Bray F, et al.: Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer 2010, 127:2893-2917.
• [18]Sasco AJ, Secretana MB, Straif K: Tobacco smoking and cancer: a brief review of recent epidemiological evidence. Lung Cancer 2004, 45(Suppl. 2):S3-S9.
• [19]IARC Working Group: IARC Monographs: On the evaluation of coarcinogenic risks to humans. Volume 96 edition. Lyon: Alcohol consumption; 2010.
• [20]O’Rourke M, Djukic J: Welcome to Serbia: feel free to smoke. Tob Control 2008, 17:428-430.
• [21]Knežević T, Miljuš D, Živković S, Plavšić V, Janković J, Savković S: Attributable causes of cancer in Serbia in the year 2005. Belgrade: Institute of Public Health of Serbia “Dr Milan Jovanović-Batut; 2008.
• [22]IARC working group: IARC handbooks of cancer prevention. Volume 6 edition. Lyon: Weight control and physical activity; 2002.
• [23]Renehan AG, Tyson M, Egger M, et al.: Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies. Lancet 2008, 371:569-578.
• [24]Pavlović M, Grujić V, Oshaug A: Nutrition and Physical Activity of the Population in Serbia. In Nutrition and fitness: obesity, the metabolic syndrome, cardiovascular disease, and cancer. Volume 94 edition. Edited by Simopoulos AP. Basel: Karger: World Rev Nutr Diet; 2005:51-59.
• [25]Döbrossy L: Cancer mortality in central–eastern Europe:facts behind the figures. Lancet Oncol 2002, 3(6):374-381. 8
• [26]Vostakolaei FA, Karim-Kos HE, Janssen-Heijnen MLG, Visser O, Verbeek ALM, Kiemeney LALM: The validity of the mortality to incidence ratio as a proxy for site-specific cancer survival. Eur J Public Health 2011, 21(5):573-577.
• [27]Schrijvers CTM, Mackenbach JP, Lutz JM, Quinn MJ, Coleman MP: Deprivation, stage at diagnosis and cancer survival. Int J Cancer 1995, 63(3):324-329.
• [28]Stanimirović B: National program of early detection and treatment of uterine cervical cancer. Arch Oncol 2000, 8(2):61-64.
• [29]Kesić V, Poljak M, Rogovskaya S: Cervical cancer burden and prevention activities in europe. Cancer Epidemiol Biomark Prev 2012, 21:1423-1433.
• [30]Peto J, Gilham C, Fletcher O, Ematthews F: The cervical cancer epidemic that screening has prevented in the UK. Lancet 2004, 364(9430):249-256.
• [31]Blanchard K, Colbert JA, Puri D: Mammographic screening: Patterns of use and estimated impact on breast carcinoma survival. Cancer 2004, 101(3):495-507.
• [32]Kronborg O, Fenger C, Olsen J, et al.: Randomised study of screening for colorectal cancer with faecal-occult-blood test. Lancet 1996, 348(9040):1467-1471.
• [33]Botha JL, Bray F, Sankila R, Parkin DM: Breast cancer incidence and mortality trends in 16 European countries. Eur J Cancer 2003, 39(12):1718-1729.
• [34]Ciraj-Bjelac O, Štimac FD, Aranđić KD, Brkić H: Good reasons to implement quality assurance in nationwide breast cancer screening programs in Croatia and Serbia: Results from a pilot study. Eur J Radiology 2011, 78:122-128.
• [35]Bosetti C, Bertuccio P, Levi F, Chatenoud L, Negri E, La Vecchia C: The decline in breast cancer mortality in Europe: An update (to 2009). Breast 2012, 21:77-82.
• [36]Janković J, Sipetić S: The rising incidence and mortality of prostate cancer in Belgrade population. Coll Antropol 2011, 35(2):499-503.
• [37]Arbyn M, et al.: The burden of cervical cancer in south-east europe at the beginning of the 21st century. Coll Antropol 2007, 31(Suppl 2):7-10.