Age-dependent effect of high cholesterol diets on anxiety-like behavior in elevated plus maze test in rats

Behavioral and Brain Functions

Xu Hu¹  Tao Wang¹  Jia Luo²  Shan Liang²  Wei Li²  Xiaoli Wu²  Feng Jin¹  Li Wang³ 

[1] Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China

[2] University of Chinese Academy of Sciences, Beijing, China

[3] The affiliated Hospital, School of Medicine, Hangzhou Normal University, Zhejiang, China

关键词: BDNF;    Corticosterone;    Hippocampus;    Age-dependent;    Anxiety-like behavior;    High cholesterol;   

Others  :  1084009
DOI  :  10.1186/1744-9081-10-30

 received in 2014-05-16, accepted in 2014-08-25,  发布年份 2014

【 摘 要 】

Background

Cholesterol is an essential component of brain and nerve cells and is essential for maintaining the function of the nervous system. Epidemiological studies showed that patients suffering from anxiety disorders have higher serum cholesterol levels. In this study, we investigated the influence of high cholesterol diet on anxiety-like behavior in elevated plus maze in animal model and explored the relationship between cholesterol and anxiety-like behavior from the aspect of central neurochemical changes.

Methods

Young (3 weeks old) and adult (20 weeks old) rats were given a high cholesterol diet for 8 weeks. The anxiety-like behavior in elevated plus maze test and changes of central neurochemical implicated in anxiety were measured.

Results

In young rats, high cholesterol diet induced anxiolytic-like behavior, decreased serum corticosterone (CORT), increased hippocampal brain-derived neurotrophic factor (BDNF), increased hippocampal mineralocorticoid receptor (MR) and decreased glucocorticoid receptor (GR). In adult rats, high cholesterol diet induced anxiety-like behavior and increase of serum CORT and decrease of hippocampal BDNF comparing with their respective control group that fed the regular diet.

Discussion

High cholesterol diet induced age-dependent effects on anxiety-like behavior and central neurochemical changes. High cholesterol diet might affect the central nervous system (CNS) function differently, and resulting in different behavior performance of anxiety in different age period.

【 授权许可】

   
2014 Hu et al.; licensee BioMed Central Ltd.

【 图 表 】

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