Thermal, creep-recovery and viscoelastic behavior of high density polyethylene/hydroxyapatite nano particles for bone substitutes: effects of gamma radiation

BioMedical Engineering OnLine

Othman Y Alothman⁶  H Fouad²  S M Al-Zahrani³  Ayman Eshra⁵  Mohammed Fayez Al Rez¹  S G Ansari⁴ 

[1] Applied Medical Science Department, Riyadh Community College, King Saud University, Riyadh, Saudi Arabia

[2] Biomedical Engineering Department, Faculty of Engineering, Helwan University, P. O. Box 11792, Helwan, Egypt

[3] Chemical Engineering Department, Faculty of Engineering, King Saud University, P. O. Box 800, Riyadh 11421, Saudi Arabia

[4] Center for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi 110025, India

[5] Biomedical Engineering Department, Faculty of Engineering, Minia University, Minia, Egypt

[6] The Saudi Electronic University, P. O. Box 93499, Riyadh, Saudi Arabia

关键词: Gamma radiation;    DMA;    Creep;    Nano;    HA;    HDPE;   

Others  :  1084462
DOI  :  10.1186/1475-925X-13-125

 received in 2014-05-14, accepted in 2014-08-21,  发布年份 2014

【 摘 要 】

Background

High Density Polyethylene (HDPE) is one of the most often used polymers in biomedical applications. The limitations of HDPE are its visco-elastic behavior, low modulus and poor bioactivity. To improve HDPE properties, HA nanoparticles can be added to form polymer composite that can be used as alternatives to metals for bone substitutes and orthopaedic implant applications.

Method

In our previous work (BioMedical Engineering OnLine 2013), different ratios of HDPE/HA nanocomposites were prepared using melt blending in a co-rotating intermeshing twin screw extruder. The accelerated aging effects on the tensile properties and torsional viscoelastic behavior (storage modulus (G’) and Loss modulus (G”)) at 80°C of irradiated and non-irradiated HDPE/HA was investigated. Also the thermal behavior of HDPE/HA were studied. In this study, the effects of gamma irradiation on the tensile viscoelastic behavior (storage modulus (E’) and Loss modulus (E”)) at 25°C examined for HDPE/HA nanocomposites at different frequencies using Dynamic Mechanical Analysis (DMA). The DMA was also used to analyze creep-recovery and relaxation properties of the nanocomposites. To analyze the thermal behavior of the HDPE/HA nanocomposite, Differential Scanning Calorimetry (DSC) was used.

Results

The microscopic examination of the cryogenically fractured surface revealed a reasonable distribution of HA nanoparticles in the HDPE matrix. The DMA showed that the tensile storage and loss modulus increases with increasing the HA nanoparticles ratio and the test frequency. The creep-recovery behavior improves with increasing the HA nanoparticle content. Finally, the results indicated that the crystallinity, viscoelastic, creep recovery and relaxation behavior of HDPE nanocomposite improved due to gamma irradiation.

Conclusion

Based on the experimental results, it is found that prepared HDPE nanocomposite properties improved due to the addition of HA nanoparticles and irradiation. So, the prepared HDPE/HA nanocomposite appears to have fairly good comprehensive properties that make it a good candidate as bone substitute.

【 授权许可】

   
2014 Alothman et al.; licensee BioMed Central Ltd.

【 图 表 】

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【 参考文献 】

• [1]Yi Z, Yubao L, Jidong L, Xiang Z, Hongbing L, Yuanyuan W, Weihu Y: Novel bio-composite of hydroxyapatite reinforced polyamide and polyethylene. Composition and properties. Mater Sci Eng A 2007, 452–453:512-517.
• [2]Sousa RA, Reis RL, Cunha AM, Bevis MJ: Processing and properties of bone-analogue biodegradable and bioinert polymeric composites. Composites Sci Technol 2003, 63:389-402.
• [3]Bonfield W, Grynpas MD, Tully AE, Bowman J, Abram J: Hydroxyapatite reinforced polyethylene-a mechanically compatible implant material for bone replacement. Biomaterials 1981, 2:185-196.
• [4]Fang L, Leng Y, Gao P: Processing of hydroxyapatite reinforced ultrahigh molecular weight polyethylene for biomedical applications. Biomaterials 2005, 26:3471-3478.
• [5]Joseph R, McGregor WJ, Martyn MT, Tanner KE, Coates PD: Effect of hydroxyapatite morphology/surface area on the rheology and processability of hydroxyapatite filled polyethylene composites. Biomaterials 2002, 23:4295-4302.
• [6]Fang L, Leng Y, Gao P: Processing and mechanical properties of HA/UHMWPE nanocomposites. Biomaterials 2006, 27:3701-3707.
• [7]Albano C, Cataño L, Figuera L, Perera R, Karam A, González G, Noris K: Evaluation of a composite based on high-density polyethylene filled with surface -treated hydroxyapatite. Polymer Bull 2009, 62:45-55.
• [8]Sapuan SM, Mustapha F, Majid DL, Leman Z, Ariff AHM, Ariffin MKA, Zuhri MYM, Ishak MR, Sahari J: Effect of hydroxyapatite reinforced high density polyethylene composites on mechanical and bioactivity properties. Key Eng Mater 2011, 471–472:303-308.
• [9]Fouad H: Effects of the bone-plate material and the presence of a gap between the fractured bone and plate on the predicted stresses at the fractured bone. Med Eng Phys 2010, 32:783-789.
• [10]Fouad H: Assessment of function-graded materials as fracture fixation bone-plates under combined loading conditions using finite element modeling. Med Eng Phys 2011, 33:456-463.
• [11]Nagels J, Stokdijk M, Rozing PM: Stress shielding and bone resorption in shoulder arthroplasty. J Shoulder Elbow Surg 2003, 12:35-39.
• [12]Li K, Tjong SC: Preparation and mechanical and tribological properties of high-density polyethylene/hydroxyapatite nanocomposites. J Macromol Sci Phys 2011, 50:1325-1337.
• [13]Pielichowska K, Blazewicz S: Bioactive polymer/hydroxyapatite (Nano) composites for bone tissue regeneration. Adv Polymer Sci 2010, 232:97-207.
• [14]Tanner KE, Downes RN, Bonfield W: Clinical applications of hydroxyapatite reinforced materials. Brit Ceram Trans 1994, 93:104-107.
• [15]Younesi M, Bahrololoom ME: Producing toughened PP/HA-LLDPE ternary bio-composite using a two-step blending method. Mater Des 2009, 30:4253-4259.
• [16]Albano C, Perera R, Cataño L, Karam A, González G: Prediction of mechanical properties of composites of HDPE/HA/EAA. J Mech Behav Biomed Mater 2011, 4:467-475.
• [17]Fouad H, Elleithy R: High density polyethylene/graphite nano-composites for total hip joint replacements; processing and in vitro characterization. J Mech Behav Biomed Mater 2011, 7:1376-1383.
• [18]Fouad H, Elleithy R, Al-Zahrani SM, Al-haj Ali M: Characterization and processing of high density polyethylene/carbon nano-composites. Mater Des 2011, 32:1974-1980.
• [19]Fouad H, Elleithy R, Alothman OY: Thermo-mechanical, wear and fracture behavior of high-density polyethylene/hydroxyapatite nano composite for biomedical applications: effect of accelerated ageing. J Mater Sci Tech 2013, 29:573-581.
• [20]Mourad A-H I, Fouad H, Elleithy R: Impact of some environmental conditions on the tensile, creep-recovery, relaxation, melting and crystallinity behaviour of UHMWPE-GUR 410-medical grade. Mater Des 2009, 30:4112-4119.
• [21]Fouad H: Effect of long-term natural aging on the thermal, mechanical, and viscoelastic behavior of biomedical grade of ultra high molecular weight polyethylene. J Appl Polym Sci 2010, 118:17-24.
• [22]Carmen A, Arquímedes K, Rosestela P, Gema G, Nohemy D, Jeanette G, Yanixia S: HDPE/HA composites obtained in solution: effect of the gamma radiation. Nucl Instr Meth Phys Res B 2006, 247:331-341.
• [23]Wannomae KK, Christensen SD, Freiberg AA, Bhattacharyya S, Harris WH, Muratoglu OK: The effect of real-time aging on the oxidation and wear of highly cross-linked UHMWPE acetabular liners. Biomaterials 2006, 27:1980-1987.
• [24]Kane JR, Converse GL, Roede RK: Effects of the reinforcement morphology on the fatigue properties of hydroxyapatite reinforced polymers. J Mech Behav Biomed Mater 2008, 1:261-268.
• [25]Soltania Z, Ziaieb F, Ghaffaric M, Afarideha H, Ehsanid M: Mechanical and thermal properties and morphological studies of 10 MeV electron beam irradiated LDPE/hydroxyapatite nano-composite. Radiat Phys Chem 2013, 83:79-85.
• [26]Yakov BU, Arthur LB, Emmanuel MG: Creep behavior of linear low-density polyethylene films. J Met Mater Miner 2006, 16:1-6.
• [27]Yeoa SS, Hsuanb YG: Evaluation of creep behavior of high density polyethylene and polyethylene-terephthalate geogrids. Geotext Geomembr 2010, 28:409-421.
• [28]ASTM D638-98: Standard Test Method for Tensile Properties of Plastics. 0801st edition. PA, USA; [1999 Annual Book of ASTM Standards]
• [29]Albano C, Karam1 A, González G, Domínguez N, Sánchez Y, Manzo F, Guzmán-García C: Effect of gamma irradiation on HDPE/HA (80:20) composites. Polymers Adv Technol 2005, 16:283-285.
• [30]Premnath V, Bellare A, Merrill EW, Jasty M, Harris WH: Molecular rearrangements in ultra high molecular weight polyethylene after irradiation and long-term storage in air. Polymer 1999, 40:2215-2229.
• [31]Othman YA, Fahad NA, Fouad H: Effect of gamma radiation and accelerated aging on the mechanical and thermal behavior of HDPE/HA nano-composites for bone tissue regeneration. BioMedical Engineering OnLine 2013, 12:95. BioMed Central Full Text
• [32]Bikiaris B: Can nanoparticles really enhance thermal stability of polymers? Part I: an overview on thermal decomposition of addition polymers. Thermochim Acta 2011, 523:25-45.
• [33]McCrum NG, Read BE, Williams G: An-Elastic and Dielectric Effects in Polymeric Solids. New York: Dover Publications; 1991.