Effects of personality traits on the manifestations of irritable bowel syndrome

BioPsychoSocial Medicine

Jun Tayama³  Naoki Nakaya¹  Toyohiro Hamaguchi⁴  Tadaaki Tomiie²  Masae Shinozaki⁵  Tatsuo Saigo³  Susumu Shirabe³  Shin Fukudo⁵ 

[1] Department of Preventive Medicine and Epidemiology, Tohoku Medical Megabank Organization, Tohoku University, Tohoku, Japan

[2] School of Psychological Science, Health Sciences University of Hokkaido, Hokkaido, Japan

[3] Center for Health and Community Medicine, Nagasaki University, Nagasaki, Japan

[4] Department of Occupational Therapy, School of Health and Social Services, Saitama Prefectural University, Saitama, Japan

[5] Department of Behavioral Medicine, Tohoku University Graduate School of Medicine, Tohoku, Japan

关键词: Brain- gut interactions;    Neuroticism;    Depression;    Irritable bowel syndrome;    Personality;   

Others  :  1082367
DOI  :  10.1186/1751-0759-6-20

 received in 2012-07-31, accepted in 2012-10-10,  发布年份 2012

【 摘 要 】

Objective

Previous studies have reported that patients with irritable bowel syndrome (IBS) show high neuroticism. However, the precise association between the IBS subtypes and the degree of neuroticism in younger populations is largely unknown. We tested our hypothesis that subjects with diarrhea-predominant IBS may have a higher degree of neuroticism than subjects without IBS or those with other subtypes of IBS. We also verified the additional hypothesis that the severity of neuroticism might be correlated with the severity of IBS in younger populations.

Methods

We conducted a cross-sectional survey of 557 university students, ranging in age from 18 to 21 years. Presence/ absence of IBS and determination of the IBS subtype was by the Rome II Modular Questionnaire, while the severity of IBS was determined by the IBS severity index (IBS-SI). The degree of neuroticism was evaluated using the Maudsely Personality Inventory (MPI). The presence/absence of psychological distress was measured with the K6 scale.

Results

Neuroticism scores in the subjects with diarrhea-predominant IBS were significantly higher than those in the non-IBS subjects or subjects with constipation-predominant IBS. The neuroticism scores were significantly correlated with the IBS-SI scores in all subjects with IBS.

Conclusion

These results suggest that neuroticism is involved in the pathophysiology of IBS in young subjects, especially in that of the diarrhea-predominant subtype.

【 授权许可】

   
2012 Tayama et al.; licensee BioMed Central Ltd.

【 图 表 】

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【 参考文献 】

• [1]Mayer EA, Raybould HE: Role of visceral afferent mechanism in functional bowel disorders. Gastroenterology 1990, 99:1688-1704.
• [2]Sagami Y, Shimada Y, Tayama J, Nomura T, Satake M, Endo Y, Shoji T, Karahashi K, Hongo M, Fukudo S: Effect of a corticotropin-releasing hormone receptor antagonist on colonic sensory and motor function in patients with irritable bowel syndrome. Gut 2004, 53:958-964.
• [3]Drossman DA, Sandler RS, McKee DC, Levity AJ: Bowel Patterns among subjects not seeking health care. Gastroenterology 1982, 83:529-532.
• [4]Richie J: Pain from distension of the pervic colon by inflating a balloon in the irritable bowel syndrome. Gut 1973, 14:125-132.
• [5]Whitehead WE, Schuster MM: Irritable bowel syndrome: definition of the syndrome and relation to other disorder. In Gastrointestinal disorders: behavioral and physiological basis for treatment. New York: Academic; 1985:155-177.
• [6]Osterberg E, Blomquist L, Krakau I, Weinryb RM, Asberg M, Hultcrantz R: A population study on irritable bowel syndrome and mental health. Scand J Gastroenterol 2000, 35:264-268.
• [7]Whitehead WE, Palsson O, Jones KR: Systematic review of the comorbidity of irritable bowel syndrome with other disorders: what are the causes and implications? Gastroenterology 2002, 122:1140-1156.
• [8]Ladep NG, Obindo TJ, Audu MD, Okeke EN, Malu AO: Depression in patients with irritable bowel syndrome in Jos, Nigeria. World J Gastroenterol 2006, 12:7844-7847.
• [9]Eriksson EM, Andrén KI, Eriksson HT, Kurlberg GK: Irritable bowel syndrome subtypes differ in body awareness, psychological symptoms and biochemical stress markers. World J Gastroenterol 2008, 14:4889-4896.
• [10]Palmer RL, Stonehill E, Crisp AH, Waller SL, Misiewicz JJ: Psychological characteristics of patients with the irritable bowel syndrome. Postgrad Med J 1974, 50:416-419.
• [11]Mousavinasab SM, Gorganinezhad-Moshiri M, Saberifirouzi M, Dehbozorgi G, Mehrabani D: Personality characteristics and irritable bowel syndrome in Shiraz, southern Iran. Saudi J Gastroenterol 2007, 13:168-171.
• [12]Farnam A, Somi MH, Sarami F, Farhang S, Yasrebinia S: Personality factors and profiles in variants of irritable bowel syndrome. World J Gastroenterol 2007, 13:6414-6418.
• [13]Farnam A, Somi MH, Sarami F, Farhang S: Five personality dimensions in patients with irritable bowel syndrome. Neuropsychiatr Dis Treat 2008, 4:959-962.
• [14]Tanum L, Malt UF: Personality and physical symptoms in nonpsychiatric patients with functional gastrointestinal disorder. J Psychosom Res 2001, 50:139-146.
• [15]Miwa H: Prevalence of irritable bowel syndrome in Japan: Internet survey using Rome III criteria. Patient Prefer Adherence 2008, 2:143-147.
• [16]Sugaya N, Nomura S: Relationship between cognitive appraisals of symptoms and negative mood for subtypes of irritable bowel syndrome. BioPsychoSocial Medicine 2008, 2:9. BioMed Central Full Text
• [17]Batterham PJ, Glozier N, Christensen H: Sleep disturbance, personality and the onset of depression and anxiety: Prospective cohort study. Aust N Z J Psychiatry 2012.
• [18]Haas BW, Omura K, Constable RT, Canli T: Emotional conflict and neuroticism: personality-dependent activation in the amygdala and subgenual anterior cingulate. Behav Neurosci 2007, 121:249-256.
• [19]Singh RK, Pandey HP, Singh RH: Correlation of serotonin and monoamine oxidase levels with anxiety level in diarrhea-predominant irritable bowel syndrome. Indian J Gastroenterol 2003, 22:88-90.
• [20]Thompson WG, Longstreth GF, Drossman DA, Heaton KW, Irvine EJ, Müller-Lissner SA: Functional bowel disorders and functional abdominal pain. Gut 1999, 45(Suppl 2):II43-II47.
• [21]Drossman DA, Talley NJ, Whitehead WE, Thompson WE, Corazziari E: Research diagnostic questions for functional gastrointestinal disorders: Rome II Modular Questionnaire: Investigator and Respondent Forms. In Rome II The Functional Gastrointestinal Disorders. 2nd edition. Edited by Drossman DA, Corazziari E, Talley NJ, Thompson WG, Whitehead WE. Boston: McLean: Degnon Associates; 2000:669-688.
• [22]Shinozaki M, Kanazawa M, Sagami Y, Endo Y, Hongo M, Drossman DA, et al.: Validation of the Japanese version of the Rome II modular questionnaire and irritable bowel syndrome severity index. J Gastroenterol 2006, 41:491-494.
• [23]Francis CY, Morris J, Whorwell PJ: The irritable bowel severity scoring system: a simple method of monitoring irritable bowel syndrome and its progress. Aliment Pharmacol Ther 1997, 11:395-402.
• [24]Kessler RC, Andrews G, Colpe LJ, Hiripi E, Mroczek DK, Normand SL, Walters EE, Zaslavsky AM: Short screening scales to monitor population prevalences and trends in non-specific psychological distress. Psychol Med 2002, 32:959-976.
• [25]Furukawa TA, Kessler RC, Slade T, Andrews G: The performance of the K6 and K10 screening scales for psychological distress in the Australian National Survey of Mental Health and Well-Being. Psychol Med 2003, 33:357-362.
• [26]Jensen AR: The Maudsley Personality Inventory. Acta Psychol 1958, 14:314-325.
• [27]Kubo M, Fujiwara Y, Shiba M, Kohata Y, Yamagami H, Tanigawa T, Watanabe K, Watanabe T, Tominaga K, Arakawa T: Differences between risk factors among irritable bowel syndrome subtypes in Japanese adults. Neurogastroenterol Motil 2011, 23:249-254.
• [28]Tana C, Umesaki Y, Imaoka A, Handa T, Kanazawa M, Fukudo S: Altered profiles of intestinal microbiota and organic acids may be the origin of symptoms in irritable bowel syndrome. Neurogastroenterol Motil 2010, 22:512-519.
• [29]Sakurai K, Nishi A, Kondo K, Yanagida K, Kawakami N: Screening performance of K6/K10 and other screening instruments for mood and anxiety disorders in Japan. Psychiatry Clin Neurosci 2011, 65:434-441.
• [30]Kuriyama S, Nakaya N, Ohmori-Matsuda K, Shimazu T, Kikuchi N, Kakizaki M, Sone T, Sato F, Nagai M, Sugawara Y, Akhter M, Higashiguchi M, Fukuchi N, Takahashi H, Hozawa A, Tsuji I: Factors Associated With Psychological Distress in a Community-Dwelling Japanese Population: The Ohsaki Cohort 2006 Study. J Epidemiol 2009, 19:294-302.
• [31]Iwawaki S, Oyama T, Sugiyama Y, Kikuchi M, Komatsu R: Development and validation of the Japanese version of the MPI (Maudsley Personality Inventory). Jpn Psychol Res 1970, 12:176-183.
• [32]Chang L, Heitkemper MM: Gender Differences in Irritable Bowel Syndrome. Gastroenterology 2002, 123:1686-1701.
• [33]Barnhofer T, Chittka T: Cognitive reactivity mediates the relationship between neuroticism and depression. Behav Res Ther 2010, 48:275-281.
• [34]Brown TA, Rosellini AJ: The direct and interactive effects of neuroticism and life stress on the severity and longitudinal course of depressive symptoms. J Abnorm Psychol 2011, 120:844-856.
• [35]Nemeroff CB, Widerlöv E, Bissette G, Walléus H, Karlsson I, Eklund K, Kilts CD, Loosen PT, Vale W: Elevated concentrations of CSF corticotropin-releasing factor-like immunoreactivity in depressed patients. Science 1984, 226:1342-1344.
• [36]Rubin RT, Phillips JJ, Sadow TF, McCracken JT: Adrenal gland volume in major depression. Increase during the depressive episode and decrease with successful treatment. Arch Gen Psychiatry 1995, 52:213-218.
• [37]MacMaster FP, Kusumakar V: MRI study of the pituitary gland in adolescent depression. J Psychiatr Res 2004, 38:231-236.
• [38]Mönnikes H, Schmidt BG, Taché Y: Psychological stress-induced accelerated colonic transit in rats involves hypothalamic corticotrophin-releasing factor. Gastroenterology 1993, 104:716-723.
• [39]Tyrka AR, Mello AF, Mello MF, Gagne GG, Grover KE, Anderson GM, Price LH, Carpenter LL: Temperament and hypothalamic-pituitary-adrenal axis function in healthy adults. Psychoneuroendocrinology 2006, 31:1036-1345.
• [40]Fukudo S, Nomura T, Hongo M: Impact of corticotropin-releasing hormone on gastrointestinal motility and adrenocorticotropic hormone in normal controls and patients with irritable bowel syndrome. Gut 1998, 42:845-849.
• [41]Tayama J, Sagami Y, Shimada Y, Hongo M, Fukudo S: Effect of alpha-helical CRH on quantitative electroencephalogram in patients with irritable bowel syndrome. Neurogastroenterol Motil 2007, 19:471-483.
• [42]Weissman MM, Bland RC, Canino GJ, Faravelli C, Greenwald S, Hwu HG, Joyce PR, Karam EG, Lee CK, Lellouch J, Lépine JP, Newman SC, Rubio-Stipec M, Wells JE, Wickramaratne PJ, Wittchen H, Yeh EK: Cross-national epidemiology of major depression and bipolar disorder. JAMA 1996, 276:293-299.
• [43]Gwee KA: Irritable bowel syndrome in developing countries – disorder of civilization or colonization? Neurogastroenterol Motil 2005, 17:317-324.
• [44]Gwee KA, Lu CL, Ghoshal UC: Epidemiology of irritable bowel syndrome in Asia: something old, something new, something borrowed. J Gastroenterol Hepatol 2009, 24:1601-1607.