Effects of BPA and BPS exposure limited to early embryogenesis persist to impair non-associative learning in adults

Behavioral and Brain Functions

Mahlet D. Mersha¹  Bansri M. Patel²  Dipen Patel¹  Brittany N. Richardson¹  Harbinder S. Dhillon¹ 

[1] Department of Biological Sciences, Delaware State University, Dover 19901, DE, USA

[2] Neuroscience and Psychology Program, University of Pittsburgh, Pittsburgh 15260, PA, USA

关键词: EDC;    BPS;    BPA;    Autism;    Development;    Embryonic exposure;    C. elegans;    Habituation;    Endocrine disrupting compounds;    Bisphenol-S;    Bisphenol-A;   

Others  :  1225140
DOI  :  10.1186/s12993-015-0071-y

 received in 2015-05-11, accepted in 2015-08-12,  发布年份 2015

【 摘 要 】

Background

Bisphenol-A (BPA) is a polymerizing agent used in plastic bottles and several routinely used consumer items. It is classified among endocrine disrupting chemicals suspected to cause adverse health effects in mammals ranging from infertility and cancer to behavioral disorders. Work with the invertebrate lab model Caenorhabditis elegans has shown that BPA affects germ cells by disrupting double-stranded DNA break repair mechanisms. The current study utilizes this model organism to provide insight into low-dose and long-term behavioral effects of BPA and bisphenol-S (BPS), a supposed safer replacement for BPA.

Findings

Experiments presented in our report demonstrate that the effects of embryonic exposure to considerably low levels of BPA persist into adulthood, affecting neural functionality as assayed by measuring habituation to mechano-sensory stimuli in C. elegans. These results are noteworthy in that they are based on low-dose exposures, following the rationale that subtler effects that may not be morphologically apparent are likely to be discernible through behavioral changes. In addition, we report that embryonic exposure to BPS follows a pattern similar to BPA.

Conclusions

Building upon previous observations using the C. elegans model, we have shown that exposure of embryos to BPA and BPS affects their behavior as adults. These long-term effects are in line with recommended alternate low-dose chemical safety testing approaches. Our observation that the effects of BPS are similar to BPA is not unexpected, considering their structural similarity. This, to our knowledge, is the first reported behavioral study on low-dose toxicity of any endocrine disrupting chemical in C. elegans.

【 授权许可】

   
2015 Mersha et al.

【 图 表 】

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