Genetic moderation of the association between regulatory focus and reward responsiveness: a proof-of-concept study

Biology of Mood & Anxiety Disorders

Elena L Goetz³  Ahmad R Hariri²  Diego A Pizzagalli¹  Timothy J Strauman³ 

[1] Department of Psychiatry, Harvard University Medical School, Boston, MA, USA

[2] Institute for Genome Sciences and Policy, Duke University, Durham, NC, USA

[3] Department of Psychology & Neuroscience, Duke University, Durham, NC, USA

关键词: COMT;    Dopamine;    Reward responsiveness;    Self-regulation;    Regulatory focus;   

Others  :  792027
DOI  :  10.1186/2045-5380-3-3

 received in 2012-07-27, accepted in 2012-11-14,  发布年份 2013

【 摘 要 】

Background

Recent studies implicate individual differences in regulatory focus as contributing to self-regulatory dysfunction, particularly not responding to positive outcomes. How such individual differences emerge, however, is unclear. We conducted a proof-of-concept study to examine the moderating effects of genetically driven variation in dopamine signaling, a key modulator of neural reward circuits, on the association between regulatory focus and reward cue responsiveness.

Method

Healthy Caucasians (N=59) completed a measure of chronic regulatory focus and a probabilistic reward task. A common functional genetic polymorphism impacting prefrontal dopamine signaling (COMT rs4680) was evaluated.

Results

Response bias, the participants’ propensity to modulate behavior as a function of reward, was predicted by an interaction of regulatory focus and COMT genotype. Specifically, self-perceived success at achieving promotion goals predicted total response bias, but only for individuals with the COMT genotype (Val/Val) associated with relatively increased phasic dopamine signaling and cognitive flexibility.

Conclusions

The combination of success in promotion goal pursuit and Val/Val genotype appears to facilitate responding to reward opportunities in the environment. This study is among the first to integrate an assessment of self-regulatory style with an examination of genetic variability that underlies responsiveness to positive outcomes in goal pursuit.

【 授权许可】

   
2013 Goetz et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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