A population-based cross-sectional study of colorectal cancer screening practices of first-degree relatives of colorectal cancer patients

BMC Cancer

Jody Simmons⁶  Daniel Barker⁵  David Hill²  Catherine D’Este⁵  Finlay A Macrae³  Robert W Sanson-Fisher⁴  Mariko L Carey⁴  Christine L Paul⁴  Ryan J Courtney¹ 

[1]Priority Research Centre for Health Behaviour, University of Newcastle, Room 269a, Level 2, David Maddison Building, Callaghan, 2308, Australia

[2]Professorial Fellow, University of Melbourne, Melbourne, Australia

[3]Department of Colorectal Medicine and Genetics, The Royal Melbourne Hospital, Melbourne, Australia

[4]Hunter Medical Research Institute, University of Newcastle, Callaghan, Australia

[5]The Centre for Clinical Epidemiology and Biostatistics, Faculty of Health, University of Newcastle, Callaghan, Australia

[6]Centre for Behavioural Research in Cancer, Cancer Council Victoria, Melbourne, Australia

关键词: Family history;    Early detection;    Prevention;    Screening;    Colorectal cancer;   

Others  :  1079977
DOI  :  10.1186/1471-2407-13-13

 received in 2012-08-15, accepted in 2012-12-27,  发布年份 2013

【 摘 要 】

Background

The aim of this study was to determine the proportions and predictors of first-degree relatives (FDRs) of colorectal cancer (CRC) patients (i) ever receiving any CRC testing and (ii) receiving CRC screening in accordance with CRC screening guidelines.

Methods

Colorectal cancer patients and their FDRs were recruited through the population-based Victorian Cancer Registry, Victoria, Australia. Seven hundred and seven FDRs completed telephone interviews. Of these, 405 FDRs were deemed asymptomatic and eligible for analysis.

Results

Sixty-nine percent of FDRs had ever received any CRC testing. First-degree relatives of older age, those with private health insurance, siblings and FDRs who had ever been asked about family history of CRC by a doctor were significantly more likely than their counterparts to have ever received CRC testing. Twenty-five percent of FDRs “at or slightly above average risk” were adherent to CRC screening guidelines. For this group, adherence to guideline-recommended screening was significantly more likely to occur for male FDRs and those with a higher level of education. For persons at “moderately increased risk” and “potentially high risk”, 47% and 49% respectively adhered to CRC screening guidelines. For this group, guideline-recommended screening was significantly more likely to occur for FDRs who were living in metropolitan areas, siblings, those married or partnered and those ever asked about family history of CRC.

Conclusions

A significant level of non-compliance with screening guidelines was evident among FDRs. Improved CRC screening in accordance with guidelines and effective systematic interventions to increase screening rates among population groups experiencing inequality are needed.

Trial Registration

Australian and New Zealand Clinical Trial Registry: ACTRN12609000628246

【 授权许可】

   
2013 Courtney et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

【 参考文献 】

• [1]Boyle P, Levin B: International agency for research on cancer. World health organisation. World cancer report. 2008. http://www.iarc.fr/en/publications/pdfs-online/wcr/ webcite.
• [2]Alketruse SF, Kosary CL, Krapcho M, Neyman N, Aminou R, Waldron W, Ruhl J, Howlader N, Tatalovich Z, Cho H, Mariotto A, Eisner MP, Lewie DR, Cronin K, Chen HS, Feuer EJ, Stinchcomb DG, Edwards BK: National cancer institute. Surveillance epidemiology and End results. Cancer statistics review.1975-2007. http://seer.cancer.gov/csr/1975_2007/ webcite.
• [3]Mandel JS, Bond JH, Church TR, Snover DC, Bradley GM, Schuman LM, Ederer F: Reducing mortality from colorectal cancer by screening for fecal occult blood. Minnesota colon cancer control study. N Engl J Med 1993, 328:1365-1371.
• [4]Kronborg O, Fenger C, Olsen J, Jorgensen OD, Sondergaard O: Randomised study of screening for colorectal cancer with faecal occult blood test. Lancet 1996, 348:1467-1471.
• [5]Hardcastle JD, Chamberlain JO, Robinson MH, Moss SM, Amar SS, Balfour TW, James PD, Mangham CM: Randomised controlled trial of fecal occult blood screening for colorectal cancer. Lancet 1996, 348:1472-1477.
• [6]Mandel JS, Church TR, Bond JH, Ederer F, Geisser MS, Mongin SJ, Snover DC, Schuman LM: The effect of fecal occult-blood screening on the incidence of colorectal cancer. N Engl J Med 2000, 343:1603-1607.
• [7]Ananda SS, McLauglin SJ, Chen F, Hayes IP, Hunter AA, Skinner IJ, Steel MC, Jones IT, Hastie IA, Rieger NA, Shedda S, Compston DJ, Gibbs P: Initial impact of Australia's national bowel cancer screening program. Med J Aust 2009, 191:378-381.
• [8]Brenner H, Chang-Claude J, Seiler CM, Rickert A, Hoffmeister M: Protection from colorectal cancer after colonoscopy: a population based case control study. Ann Inten Med 2011, 154:22-30.
• [9]Ransohoff DF: How much does colonoscopy reduce colon cancer mortality? Ann Intern Med 2009, 150:50-52.
• [10]Crespi M, Stigliano V, Assisi D: Current trends and secondary prevention of colorectal cancer. Hepatogastroenterology 2001, 48:1635-1640.
• [11]Winawer SJ, Zauber AG, Ho MN, O'Brien MJ, Gottlieb LS, Sternberg SS, Waye JD, Schapiro M, Bond JH, Panish JF: Prevention of colorectal cancer by colonoscopic polypectomy. The national polyp study workgroup. N Engl J Med 1993, 329:1977-1981.
• [12]Winawer SJ, Fletcher RH, Miller L, Godlee F, Stolar MH, Mulrow CD, Woolf SH, Glick SN, Ganiats TG, Bond JH, Rosen L, Zapka JG, Olsen SJ, Giardiello FM, Sisk JE, VanAntwerp R, Borwn-Davis C, Marciniak DA, Mayer RJ: Colorectal cancer screening: clinical guidelines and rationale. Gastroenterology 1997, 112:594-642.
• [13]Australian cancer network and commonwealth department of health and ageing. Familial aspects of bowel cancer: a guide for health professionals. http://www.cancerscreening.gov.au/internet/screening/publishing.nsf/content/1F35A75DC194E59CCA2574EB007F7532/$File/familial-guide.pdf webcite.
• [14]St John DJB, McDermott FT, Hopper JL, Debney EA, Johnson WR, Hughes ES: Cancer risk in relatives of patients with common colorectal cancer. Ann Intern Med 1993, 118:785-790.
• [15]Lindor NM, Petersen GM, Hadley DW, Kinney AY, Miesfeldt S, Lu KH, Lynch P, Burke W, Press N: Recommendations for the care of individuals with inherited predisposition to Lynch Syndrome. JAMA 2006, 296:1507-1517.
• [16]Pariente A, Milan C, Lafon J, Faivre J: Colonoscopic screening in first-degree relatives of patients with 'sporadic' colorectal cancer: a case-control study. Gastroenterology 1998, 115:7-12.
• [17]Boultron MC, Faivre J, Quipourt V, Senesse P, Michaels C: Family history of colorectal tumours and implications for the adenoma-carcinoma sequence: a case-control study. Gut 1995, 37:830-834.
• [18]Australian Cancer Network Colorectal Cancer Guidelines Revision Committee: Clinical practice guidelines for the prevention, early detection and management of colorectal cancer. http://www.nhmrc.gov.au/guidelines/publications/cp106 webcite.
• [19]American Cancer Society: American cancer society recommendations for colorectal cancer early detection. http://www.cancer.org/Cancer/ColonandRectumCancer/MoreInformation/ColonandRectumCancerEarlyDetection/colorectal-cancer-early-detection-acs-recommendations webcite.
• [20]United States Preventive Services Task Force: Screening for colorectal cancer: U.S. Preventive services task force recommendation statement. Ann Inten Med 2008, 149:627-637.
• [21]Longacre AV, Cramer LD, Gross CP: Screening colonoscopy use among individuals at higher colorectal cancer risk. J Clin Gastroenterol 2006, 40:490-496.
• [22]Ramji F, Cotterchio M, Manno M, Rabeneck L, Gallinger S: Association between subjects factors and colorectal cancer screening participation in Ontario, Canada. Cancer Detect Prev 2005, 29:221-226.
• [23]Rees G, Martin PR, Macrae FA: Screening participation in individuals with a family history of colorectal cancer: a review. Eur J Cancer Care 2008, 17:221-232.
• [24]Courtney RJ, Paul CL, Sanson-Fisher RW, Macrae FA, Carey ML, Attia J, McEvoy M: Colorectal cancer screening in Australia: a community-level perspective. Med J Aust 2011, 196:516-520.
• [25]Armelao F, Orlandi PG, Tasini E, Franceschini G, Franch R, Paternolli C, de Pretis G: High uptake of colonoscopy in first-degree relatives of patients with colorectal cancer in a healthcare region: a population-based, prospective study. Endoscopy 2010, 42:15-21.
• [26]Bujanda L, Sarasqueta C, Zubiaurre L, Cosme A, Munoz C, Sanchez A, Martin C, Tito L, Pinol V, Castells A, Llor X, Xicola RM, Pons E, Clofent J, De Castro ML, Cuquerella J, Medina E, Gutierrez A, Arenas JI, Jover R: Low adherence to colonoscopy in the screening of first-degree relatives of patients with colorectal cancer. Gut 2007, 56:1714-1718.
• [27]Ruthotto F, Papendorf F, Wegener G, Unger G, Dlugosch B, Korangy F, Manns MP, Greten TF: Participation in screening colonoscopy in first-degree relatives from patients with colorectal cancer. Ann Oncol 2007, 18:1518-1522.
• [28]Harris MA, Byles JE: A survey of screening compliance among first-degree relatives of people with colon cancer in New South Wales. ANZ J Public Health 1997, 4:29-34.
• [29]Manne S, Markowitz A, Winawer S, Meropol NJ, Haller D, Rakowski W, Babb J, Jandorf L: Correlates of colorectal cancer screening compliance and stage of adoption among siblings of individuals with early onset colorectal cancer. Health Psychol 2002, 21:3-15.
• [30]Thrasher JF, Cummings M, Michalek AM, Mahoney MC, Moysich KB, Pillittere DM: Colorectal cancer screening among individuals with and without a family history. J Public Health Manag Pract 2002, 8:1-9.
• [31]Ait Ouakrim D, Boussioutas A, Lockett T, Winship I, Giles GG, Flander LB, Keogh L, Hopper JL, Jenkins MA: Screening practices of unaffected people at familial risk of colorectal cancer. Cancer Prev Res 2012, 5:240-247.
• [32]Group EQ: EuroQol - a new facility for the measurement of health-related quality of life. Health Policy 1990, 16:199-208.
• [33]Levin B, Lieberman DA, McFarland B, Smith RA, Brooks D, Andrews KS, et al.: Screening and surveillance of the early detection of colorectal cancer and adenomatous polyps, 2008: a joint guideline from the american cancer society, the US multi-society task force on colorectal cancer, and the american college of radiology. CA Cancer J Clin 2008, 58:130-160.
• [34]Canadian Task Force on Preventive Health Care: Colorectal cancer screening. Recommendation statement from the canadian task force on preventive health care. CMAJ 2001 165:206-208.
• [35]Cockburn J, Paul C, Tzelepis F, McElduff , Byles J: Screening for bowel cancer among NSW adults with varying levels of risk: a community survey. ANZ J Public Health 2002, 26:236-241.
• [36]Weber MF, Banks E, Ward R, Sitas F: Population characteristics related to colorectal cancer testing in New South Wales, Australia: results from the 45 and Up Study cohort. J Med Screening 2008, 15:137-142.
• [37]Murff HJ, Peterson NB, Greevy RA, Shrubsole MJ, Zheng W: Early initiation of colorectal cancer screening in individuals with affected first-degree relatives. J Gen Intern Med 2007, 22:121-126.
• [38]Richardson JL, Danley K, Mondrus GT, Deapen D, Mack T: Adherence to screening examinations after diagnosis in a 1st-degree relative. Prev Med 1995, 24:166-170.
• [39]Kinney AY, Choi YA, DeVellis B, Kobetz E, Millikan RC, Sandler RS: Interest in genetic counselling among first-degree relatives of colorectal cancer patients. Am J Prev Med 2000, 18:249-252.
• [40]Bastini R, Gallardo NV, Maxwell AE: Barriers to colorectal cancer screening among ethnically diverse high- and average-risk individuals. J Psychosoc Oncol 2001, 19:65-84.
• [41]Mack LA, Cook LS, Temple WJ, Carlson LE, Hilsden RJ, Paolucci EO: Colorectal cancer screening among first-degree relatives of colorectal cancer patients: benefits and barriers. Ann Surg Oncol 2009, 16:2092-2100.
• [42]Javanparast S, Ward P, Young G, Wilson C, Carter S, Misan G, Cole S, Jiwa M, Tsourtos G, Martini A, Gill T, Baratiny G, Matt AM: How equitable are colorectal cancer screening programs which include FOBTs? A review of qualitative and quantitative studies. Prev Med 2010, 50:165-172.
• [43]Subramanian S, Klosterman MK, Amonkar MM, Hunt TL: Adherence with colorectal cancer screening guidelines: a review. Prev Med 2004, 38:536-550.
• [44]Codori AM, Petersen GM, Miglioretti DL, Boyd P: Health beliefs and endoscopic screening for colorectal cancer: potential for cancer prevention. Prev Med 2001, 33:128-136.
• [45]Matthews BA, Anderson RC, Nattinger AB: Colorectal cancer screening behavior and health insurance status. Cancer Causes Control 2005, 16:735-742.
• [46]Manne SL, Coups EJ, Winkel G, Markowitz A, Meropol NJ, Lesko SM, Jacobsen PB, Haller D, Jandorf L, Peterson SK: Identifying cluster subtypes for intentions to have colorectal cancer screening among non-compliant intermediate-risk siblings of individuals with colorectal cancer. Health Educ Res 2009, 24:897-808.
• [47]Madlensky L, Esplen MJ, Gallinger S, McLaughlin JR, Goel V: Relatives of colorectal cancer patients. Factors associated with screening behavior. Am J Prev Med 2003, 25:187-194.
• [48]Schvartzman P, Rivking E, Neville A, Friger M, Sperber AD: Screening intention and practice among first-degree relatives of colorectal cancer patients in Southern Israel. Israel Medical Association Journal 2000, 2:675-678.
• [49]von Euler-Chelpin M, Brasso K, Lynge E: Determinants of participation in colorectal cancer screening with faecal occult blood testing. J Public Health 2010, 32:395-405.
• [50]Guessous I, Dash C, Lapin P, Doroshenk M, Smith RA, Klabunde CN: Colorectal cancer screening barriers and facilitators in older persons. Prev Med 2010, 50:3-10.
• [51]Beydoun HA, Beydoun MA: Predictors of colorectal cancer screening behaviors among average-risk older adults in the United States. Cancer Causes Control 2008, 19:339-359.
• [52]The National Bowel Cancer Screenining Program Quality Working Group: Improving colonoscopy services in Australia. http://www.cancerscreening.gov.au/internet/screening/publishing.nsf/Content/3FD09B61D2B4E286CA25770B007D1537/$File/Improving%20col%20serv0709.pdf webcite.
• [53]Schroy PC, Barrison AF, Ling BS, Wilson S, Geller AC: Family history and colorectal cancer screening: a survey of physician knowledge and practice patterns. Am J Gastroenterol 2002, 97:1031-1036.
• [54]Murff HJ, Greevy RA, Syngal S: The comprehensiveness of family cancer history assessments in primary care. Community Genet 2007, 10:174-180.
• [55]Sifri RD, Wender R, Paynter BS: Cancer risk assessment from family history: gaps in primary care practice. J Fam Pract 2002, 51:856.
• [56]Kelly KM, Sweet K: In search of a familial risk assessment tool. Clin Genet 2007, 71:76-83.
• [57]Westman J, Hampel H, Bradley T: Efficacy of touchscreen computer based family cancer history questionnaire and subsequent cancer risk assessment. J Med Genet 2000, 37:354-360.
• [58]McLeod RS: Canadian task force on preventive health care. Screening strategies for colorectal cancer: a systematic review of the evidence. Can J Gastroenterol 2001, 15:647-660.
• [59]Delgado-Plasencia L, Lopez-Tomassetti-Fernandez E, Hernandez-Morales A, Torres-Monzon E, Gonzalez-Hermoso F: Willingness to undergo colorectal cancer screening in first-degree relatives of hospitalized patients with colorectal cancer. J Med Screen 2009, 16:33-38.
• [60]Ziogas A, Anton-Culver H: Validation of family history data in cancer family registries. Am J Prev Med 2003, 24:190-198.
• [61]Murff HJ, Spigel DR, Syngal S: Does this patient have a family history of cancer? An evidence-based analysis of the accuracy of family cancer history. JAMA 2004, 12:1480-1489.
• [62]Khoja S, McGregor ES, Hilsden RJ: Validation of self-reported history of colorectal cancer screening. Can Fam Physician 2007, 53:1192-1197.
• [63]Baier M, Calonge N, Cutter G, McClatchey M, Schoentgen S, Hines S, Marcus A, Ahnen D: Validity of self reported colorectal cancer screening behaviour. Cancer Epidemiol Biomarkers Prev 2000, 9:229-232.