Synthesis and characteristics of (Hydrogenated) ferulic acid derivatives as potential antiviral agents with insecticidal activity

Chemistry Central Journal

Guang-Ying Huang¹  Can Cui¹  Zhi-Peng Wang¹  Yong-Qiang Li¹  Li-Xia Xiong¹  Li-Zhong Wang¹  Shu-Jing Yu¹  Zheng-Ming Li¹  Wei-Guang Zhao¹ 

[1] State Key Laboratory of Elemento-Organic Chemistry, National Pesticide Engineering Research Center (Tianjin), Nankai University, Tianjin 300071, China

关键词: Tobacco mosaic virus;    Insecticidal activity;    Antiviral activity;    Ferulic acid amide;    Synthesis;   

Others  :  787959
DOI  :  10.1186/1752-153X-7-33

 received in 2012-12-27, accepted in 2013-01-30,  发布年份 2013

【 摘 要 】

Background

Plant viruses cause many serious plant diseases and are currently suppressed with the simultaneous use of virucides and insecticides. The use of such materials, however, increases the amounts of pollutants in the environment. To reduce environmental contaminants, virucides with insecticidal activity is an attractive option.

Results

A series of substituted ferulic acid amide derivatives 7 and the corresponding hydrogenated ferulic acid amide derivatives 13 were synthesized and evaluated for their antiviral and insecticidal activities. The majority of the synthesized compounds exhibited good levels of antiviral activity against the tobacco mosaic virus (TMW), with compounds 7a, 7b and 7d in particular providing higher levels of protective and curative activities against TMV at 500 μg/mL than the control compound ribavirin. Furthermore, these compounds displayed good insecticidal activities against insects with piercing-sucking mouthparts, which can spread plant viruses between and within crops.

Conclusions

Two series of ferulic acid derivatives have been synthesized efficiently. The bioassay showed title compounds not only inhibit the plant viral infection, but also prevented the spread of plant virus by insect vectors. These findings therefore demonstrate that the ferulic acid amides represent a new template for future antiviral studies.

【 授权许可】

   
2013 Huang et al; licensee Chemistry Central Ltd.

【 图 表 】

Figure 1.

Scheme 1

Scheme 2

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