HIV-1 Subtype distribution in morocco based on national sentinel surveillance data 2004-2005

AIDS Research and Therapy

Mohammed Akrim¹  Sanae Lemrabet¹  Elmir Elharti⁴  Rebecca R Gray⁶  Jean Claude Tardy³  Robert L Cook⁵  Marco Salemi²  Patrice Andre³  Taj Azarian⁵  Rajae El Aouad⁴ 

[1] Molecular Biology Unit, National Reference Laboratory for HIV, National Institute of Hygiene, Rabat, Morocco

[2] Department of Pathology, Immunology and Laboratory Medicine, School of Medicine and Emerging Pathogens Institute, University of Florida, Gainesville, USA

[3] Laboratoire de Virologie, Hôpital de la Croix Rousse, Lyon, France

[4] HIV Diagnosis and Immunologic Follow up Unit, National Reference Laboratory for HIV, National Institute of Hygiene, Rabat, Morocco

[5] Department of Epidemiology and Emerging Pathogens Institute, University of Florida, Gainesville, USA

[6] Department of Zoology, University of Oxford, Oxford, UK

关键词: Morocco;    phylogeny;    subtypes;    HIV-1;   

Others  :  789678
DOI  :  10.1186/1742-6405-9-5

 received in 2011-09-22, accepted in 2012-02-14,  发布年份 2012

【 摘 要 】

Background

Little is known about HIV-1 subtype distribution in Morocco. Some data suggest an emergence of new HIV subtypes. We conducted phylogenetic analysis on a nationally representative sample of 60 HIV-1 viral specimens collected during 2004-2005 through the Morocco national HIV sentinel surveillance survey.

Results

While subtype B is still the most prevalent, 23.3% of samples represented non-B subtypes, the majority of which were classified as CRF02_AG (15%). Molecular clock analysis confirmed that the initial introduction of HIV-1B in Morocco probably came from Europe in the early 1980s. In contrast, the CRF02_AG strain appeared to be introduced from sub-Saharan Africa in two separate events in the 1990s.

Conclusions

Subtype CRF02_AG has been emerging in Morocco since the 1990s. More information about the factors introducing HIV subtype-specific transmission will inform the prevention strategy in the region.

【 授权许可】

   
2012 Akrim et al; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

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