Molecular epidemiology of HIV-1 clades in Southern Brazil

Memórias do Instituto Oswaldo Cruz

Sonia Mara Raboni²  Sérgio Monteiro De Almeida²  Indianara Rotta²  Cléa Elisa Lopes Ribeiro²  Debra Rosario¹  Luine Rosele Vidal²  Meri Bordignon Nogueira²  Maristela Riedel¹  Maria Da Graça Winhescki¹  Kátia Antunes Ferreira²  Ronald Ellis¹ 

[1] ,Universidade Federal do Paraná Hospital de Clínicas Laboratório de VirologiaCuritiba PR ,Brasil

关键词: HIV;    subtypes;    genetic variability;    HIV exposure;   

DOI  :  10.1590/S0074-02762010000800015

来源: SciELO

【 摘 要 】

Human immunodeficiency virus (HIV) clades B and C account for more than 60% of the HIV-1 infections worldwide. In this paper, we describe the profiles of patients infected with subtypes of HIV-1 from the state of Paraná, Southern Brazil, and correlate them with demographic and epidemiological findings. A retrospective analysis of HIV cases reported from 1999-2007 was also performed. Data from 293 patients were reviewed and 245 were older than 13 (58% female). The distribution of clades was as follows: B 140 (57%), C 67 (23%), F 24 (10%) and mosaic or unique recombinant forms (URFs) 24 (10%). Of the 48 patients younger than 13 years of age (62.5% male), vertical transmission occurred in 46 and the distribution of clades was as follows: B 14 (29%), C 24 (50%), F 7 (15%) and URFs 6 (13%). There was no significant difference in mortality between HIV-1 subtypes. In both groups, patients infected with clade C tended to have higher rates of injection drug use exposure risk.

【 授权许可】

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